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Biomedical subjects

J Roland

Publications and source records attributed to J Roland.

At least 109 records · Page 6Linked to original sources
PubMed1987

Microvascularization of the intracranial dura mater.

The authors have studied the microvascularization of the intracranial dura mater by microradiographic and histologic examination of 73 injected anatomic specimens. There exists a very abundant superficial arterial plexus which also serves to supply the inner table of the cranial vault. This plexus is continuous, even at the walls of the venous sinuses and the dural septa. The arteries are for the most part tortuous. The veins may be satellites of the arteries or, on the contrary, from a plexiform network passing through crevices in the interior of the dural layer. The walls of these veins consist only of an endothelium to be seen within the fibrous layer of the dura. Often, the arteries compress the venous lumen; this dangerous situation probably explains the frequent occurrence of arteriovenous fistulae of the dura mater, known by the name of dural fistulae.

Adult↗
PubMed1987

Application of Grimelius argyrophil staining to the study of tumour ultrastructure. I. Effects of fixatives.

Two methods have so far been proposed for staining samples by the argyrophil technique of Grimelius for electron microscopy. For Håkanson glutaraldehyde prevented argyrophilia, so the author stained sections from samples previously fixed by double formaldehyde/osmium tetroxide treatment and embedding. Vassallo used en bloc staining after fixation with glutaraldehyde-formaldehyde mixtures. We examined each factor which could directly interfere in argyrophil staining en bloc and on section. In the present experiment we compared effects of fixatives after staining en bloc. Glutaraldehyde prevented argyrophilia in 1 case out of 15, that of A-like cells in the oxyntic gland of the rat positivity was maintained in EC-like cells of this gland and adrenalin cells of the adrenal gland contrary to the previous description.

Carcinoid Tumor↗
PubMed1987

Pulmonary Kaposi's sarcoma in patients with acquired immune deficiency syndrome: a clinicopathological study.

Pulmonary Kaposi's sarcoma may contribute to respiratory dysfunction in patients with acquired immune deficiency syndrome (AIDS) and features of pneumonitis. Opportunistic infections are readily recognised in endoscopic material, but pulmonary Kaposi's sarcoma is easily missed, so that patients are deprived of specific treatment. The clinical and pathological findings from nine cases of pulmonary Kaposi's sarcoma have been reviewed; these were found among 84 patients with AIDS and pneumonitis undergoing fibreoptic bronchoscopy and bronchoalveolar lavage. Diagnosis was established before death in eight patients (in five by bronchial biopsy and in three by open lung biopsy). Examination of lavage fluid showed alveolar haemorrhage in six patients. It is concluded that: (1) fibreoptic bronchoscopy may be useful in the diagnosis of endobronchial lesions of Kaposi's sarcoma; (2) alveolar haemorrhage in patients with AIDS is suggestive of pulmonary Kaposi's sarcoma. Factors that may cause difficulties in diagnosis include the focal nature of some lesions and the pleural or parenchymatous location of others. In addition, in the lung as in the skin, the early stages of Kaposi's sarcoma resemble granulation tissue. Such lesions are far more difficult to recognise than is the late nodular stage.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Localization of H blood group antigen in ectoblastic derivatives of murine teratocarcinoma.

Ectoblastic derivatives (ectodermal and neuroectodermal components) constitute more than 90% of all structures in the murine teratocarcinoma derived from the PCC4-aza-1 line. This tumor was labeled immunocytochemically with fluoresceinated antibodies to A, B and H blood groups. A and B antigens were always noted to be absent from all structures of the three germ layers. With anti-H, however, embryonic and fetal endodermal components, e.g. alimentary or respiratory duct-like structures, gave positive staining. Mesodermal components, i.e. bone and cartilage structures, fibroblasts and myocytes of mature or embryonal type, were negative. Immature and mature ectodermal components, viz. epidermoid cysts or islets, were always positive. Neuroectodermal components, neuroblastic cysts and differentiated neuronal, glial and ependymal elements were always negative. Ectoblastic and/or neuroectoblastic individual cells or cell clusters, observed in the vicinity of positive differentiating ectodermal and neuroectodermal structures, were positive. Similar cells or clusters were negative when located close to negative neuroectodermal components. The undifferentiated, embryonal carcinoma cells and structures were always negative. These observations are compared to the staining patterns of H antigen in murine embryos and adult mice and in human teratocarcinomas. It is suggested that poorly differentiated, morphologically similar ectoblastic and/or neuroectoblastic structures are positive, if they concern ectodermal components, and negative, if they belong to neuroectodermal components, with the exception of some primary sensory cells that are positive. These last cells are also positive in normal fetal and adult tissues.

ABO Blood-Group System↗
PubMed1987

[Effects of intracranial pressure on frontal sinus development].

Through a study of some syndromes of intra-cranial high and low pressure, the authors try to find out the relations between the intra-cranial stresses and the development of frontal sinuses. They account for the choice of frontal sinuses and the various factors determining this pneumatization. They study the morphology of the frontal sinuses in 20 cases of old and chronic hydrocephaly, in 13 cases of oxycephaly with a late diagnosis, and in 20 cases of adults suffering with infantile cerebral hemiatrophy. They show that in these syndromes, the development of frontal sinuses is an inverse ratio to the intracranial pressure. However, they point out that in standard people, the extreme differences in the morphology of their frontal pneumatization can be explained not only by various causes--a number of which is as yet not known--but also by an aleatory distribution.

Atrophy↗
PubMed1987

[Lesions of the basal ganglia in mumps. Clinical and neuroradiological development in a case].

Among mumps complications, encephalitis is the most frequent. Involvement of the basal ganglia has been previously reported associated to some other encephalic lesions. In one case, changes were confined to basal ganglia and occurred at the 10th day of evolution of mumps. Clinically a bilateral extrapyramidal syndrome was present without other neurological disorders. CT scan showed bilateral lesions in the area of the basal ganglia. The course was favorable. The neurological examination and CT scan were normal 6 months later. Such complications should be prevented by vaccination.

Basal Ganglia Diseases↗
PubMed1986

[Biliary cysts of the liver].

Biliary cysts of the liver do not communicate with the biliary tract. Eight of the 10 patients operated on were asymptomatic. The cysts were 3 to 30 cm in diameter. In 1 patient, ultrasonically guided drainage of the cyst was followed by recurrence of the lesion and pain. In another patient, a cholangiocarcinoma was discovered in the wall of the cyst. After resection of the protruding part of the cyst the pathological disorders subsided in all patients who were followed up for 6 months to 16 years.

Adult↗
PubMed1986

Allotypy of the rabbit kappa 2 light chain: evidence that the kappa 2 isotype is expressed by all members of the rabbit species.

The rabbit kappa 2 light chain subtype was described after isolation of the Basilea mutant strain, which does not express the kappa 1 subtype; antibodies raised in domestic rabbits against the Basilea kappa 2 chain recognized antigenic determinants present in Basilea strain rabbits and in some wild Oryctolagus cuniculus individuals. Some authors have proposed that the kappa 2 isotype is expressed in some individuals and is silent in others. The results presented here provide immunochemical and genetic evidence that the kappa 2 isotype presents at least two allotypic forms, bas 1 (equivalent to bas+) and bas 2 (equivalent to the so-called bas-), which are expressed in low levels in all members of the rabbit species. In addition, preliminary data on the expression of the bas 2 allotype in some hares (Lepus capensis) are reported. On the basis of these results, the rules guiding the selection of kappa 1 and kappa 2 isotypic light chain expression in this species may now be approached.

Animals↗
PubMed1986

Importance of circulating and urinary tissue kallikrein in the control of acute natriuresis and diuresis evoked by water immersion in man.

In ten human subjects water immersion produced a two-fold diuresis and a three-fold increase in sodium secretion together with a marked fall in plasma renin activity and aldosterone. In contrast, circulating and urinary (active and total kallikrein) remained unchanged throughout the immersion period. Our results indicate that the acute diuresis and natriuresis evoked by water immersion in man is not regulated by circulating or urinary tissue kallikrein.

Adult↗
PubMed1986

Primary nonseminomatous germ cell tumor of the prostate.

We describe a case of a primary nonseminomatous germ cell prostatic tumor and discuss the problem of extragonadal germ cell tumors. Prognosis, staging and management of these tumors are similar to that of metastatic primary testicular germ cell tumors.

Adult↗
PubMed1986

[Value of the cytological examination of the bronchoalveolar lavage fluid in patients with acquired immunodeficiency syndrome and related syndromes].

In AIDS a variety of severe pulmonary disorders may occur. The authors report 110 cases of bronchoalveolar lavage (BAL) in 43 AIDS and 41 ARC. In AIDS P. carinii pneumonia is the major cause of respiratory illness. BAL alone is a safe and valuable tool for diagnosis of P. carinii pneumonia and others opportunistic infections. Moreover, pulmonary hemorrhage diagnosed by the finding of hemosiderin laden macrophages, is very suggestive of broncho-pulmonary Kaposi' sarcoma. Finally, BAL demonstrates a severe depletion of T4 lymphocytes and an increased number of T8 lymphocytes. The T8 lymphocytosis is observed whatever the pulmonary involvement (nonspecific alveolitis, opportunistic infections, Kaposi's sarcoma), and is also found in ARC, and lymphocytosis, open lung biopsy shows a lymphoid interstitial infiltration with respect of the alveolar septa, thus differing from the classical lymphoid interstitial pneumonia described by Carrington. The prognosis of lymphocytosis in ARC remains unknown.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. II. Extrarenal distribution.

An immunoultrastructural study has been undertaken for analysis of the extrarenal localization of two brush border (BB) glycoproteins of 90 kd and 330 kd expressed by glomeruli. In previous studies on renal tissue, it has been shown that gp 330 is restricted to coated pits and BB intermicrovillar invaginations, whereas gp 90 is diffusely distributed on epithelial cell membranes and in addition expressed on glomerular endothelial cells. At variance from observations made in the kidney, gp 330 and gp 90 are mainly expressed on different epithelial cell types: gp 330 is found on the coated pits of the epithelium lining the epididymis and on the entire surface of the microvilli of Type II pneumocytes, whereas gp 90 is detected on the gut brush border and the biliary pole of hepatocytes; gp 90 is also found on endothelia lining all distal capillary beds studied in heart, lung, liver, and spleen. These observations thus indicate that gp 90 is expressed by a wide variety of cell types, all associated with high membrane turnover. Conversely, gp 330 has a restricted distribution at the organ, cellular and subcellular level and may be related with a defined system of receptor-mediated endocytosis.

Animals↗
PubMed1986

Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. I. Renal distribution.

The authors have previously reported the production of monoclonal anti-brush border antibodies defining two glycoprotein (gp) antigens of 90 and 330 kd which are also expressed on glomerular cells and may thus be of significance for in situ formation of immune complexes. The 330-kd antigen is involved in Heymann's nephritis, whereas the 90-kd antigen induces transient glomerular immune deposits. In this report, the authors describe the renal ultrastructural localization of the two antigens, which are both detectable on brush border and glomerular epithelial cells but assume contrasting patterns: gp 90 is diffusely present on the cell membranes, whereas gp 330 is concentrated in the intermicrovillar region and within the coated pits. Their localization within proximal tubular cells, on the membrane of intracytoplasmic vesicles, suggests that they are involved in endocytosis. In addition, gp 90 is expressed on endothelial cells lining glomerular capillaries. These observations may help us to understand the formation and different kinetics of immune glomerular deposits.

Animals↗