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Biomedical subjects

J Roed-Petersen

Publications and source records attributed to J Roed-Petersen.

At least 19 recordsLinked to original sources
PubMed1995

Skin problems among Danish dental technicians. A cross-sectional study.

Our objective was to evaluate changes in the prevalence of skin problems on the hands among dental technicians during the last 10 years by comparison with results of a previous study, to study whether the presence and location of skin problems could be related to work with acrylates, and to study whether the use of gloves had any influence on the prevalence of the skin problems. A cross-sectional questionnaire study among 192 dental technicians at work was performed using an expanded version of a questionnaire from a Danish survey 10 years ago. The cumulative prevalence of skin problems on the hands was 53%. The 1-year prevalence of skin problems on the hands was 43%. The point prevalence of skin problems on the hands was 36%. These prevalence figures were profoundly higher than the figures reported for the general population, and the figures did not differ from those obtained in the study 10 years ago. The point prevalence of skin problems on the hands among individuals handling acrylates was 38% higher than among individuals who never worked with acrylates. No difference in the occurrence of skin problems was observed between individuals using gloves and individuals who did not use gloves while handling acrylates. The prevalence difference of skin problems on the fingertips was 7.3% between individuals handling acrylates daily or several times a week and individuals handling acrylates less frequently.(ABSTRACT TRUNCATED AT 250 WORDS)

Acrylates↗
PubMed1995

Rapid increase in skin problems among dental technician trainees working with acrylates.

A panel of trainees at The Danish School of Dental Technicians was asked to fill in questionnaires 2X a year, to elucidate whether the prevalence of skin problems on their hands increased during the study and to compare the results to the general population. At the beginning of the study, trainees had a prevalence of skin problems not statistically significantly different from that in the general population. 8 months later, an increase of 23% in the prevalence was observed. Compared to the general population the standardized prevalence ratio (SPR) increased to 4.78, and compared to dental technicians at work, an SPR of 0.71 was found after 1 year of study. Very few trainees experienced relief in symptoms during the 1st year of study (5%), whereas 33% developed worse symptoms. The results demonstrate that trainees shortly after beginning their education have the same very high magnitude of skin problems as dental technicians at work. Trainees were exposed to acrylates more extensively than dental technicians. It is far from acceptable that this educational experience involves such a great risk to individuals with no experience or knowledge of the hazards of their occupational environment. Preventive actions are called for, e.g., increased use of encapsulated systems, use of gloves with a well documented protective effect and mandatory courses on the hazardous effects of dental materials.

Acrylates↗
PubMed1993

[Acne vulgaris].

Acne vulgaris is one of the most common dermatological diseases. The prevalence may be as high as 83-95% at age 16, but decreases at age 20, and is very low at age 35. The aetiology and pathogenesis are not completely known, but the following factors are involved: 1) increased sebum secretion, 2) follicular keratinisation, 3) bacteria and 4) inflammation. Furthermore, genetic and exogenic factors play a role. Acne can be divided into 5 groups depending on its severity. Treatment principles within these 5 groups are reviewed. Treatment can not be expected to take effect before 1-2 months have passed, but all patients can be cured with the right treatment. The effects and side effects of the various treatments are described. Treatment with isotretinoin should only be initiated by dermatologists.

Acne Vulgaris↗
PubMed1992

[Occlusive treatment of atrophic and erosive oral lichen planus with Clobetasol Propionate 0.05% ointment (Dermovat)].

The treatment of eight patients with histologically verified atrophic or erosive lichen planus are reported. The lesions of WHO-diagnosis code 697.02 were subdivided into three classes: atrophic, minor erosive and major erosive. Clobetasol Propionate ointment was placed in the buccal mucosa under an occlusive DuodermR dressing. Healing with striation was obtained in all of those lesions classified as atrophic or minor erosive, while major erosive lesions showed improvement, but persisted.

Aged↗
PubMed1991

Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris.

The therapeutic efficacy and tolerability of calcipotriol ointment and betamethasone valerate ointment in psoriasis were compared in a multicentre, prospective, randomised, double-blind, right/left trial. 345 inpatients and outpatients with psoriasis vulgaris of symmetrical distribution were treated twice daily for 6 weeks with calcipotriol ointment 50 micrograms/g and betamethasone ointment 0.1% randomly assigned to opposite sides of the body. The main outcome measures--the psoriasis area and severity index (PASI), the investigators' assessments of erythema, thickness, and scaling, and the patients' own assessments of the overall response to treatment--were sought at weeks 2, 4, and 6. Both treatments significantly reduced the PASI scores and the investigator's assessment scores, but at each visit the PASI score was significantly (p less than 0.001) lower with calcipotriol than with betamethasone. At 6 weeks the mean PASI reduction was 68.8% with calcipotriol and 61.4% with betamethasone (95% confidence interval for difference 5.1-9.8, p less than 0.001). The scores for erythema, thickness, and scaling were significantly (p less than 0.001) lower with calcipotriol than with betamethasone at the end of treatment. The patients considered that 82.1% of calcipotriol-treated sides and 69.3% of betamethasone-treated sides had improved greatly or cleared up by the end of treatment (p less than 0.001). 57 adverse events were reported by 52 patients (15.1%). The most common adverse event, lesional/perilesional skin irritation, was slightly but not significantly (p = 0.12) more common with calcipotriol treatment. 15 (4.3%) patients were withdrawn from the study, 3 because of local adverse events. There were no changes in serum calcium during the study. Thus, calcipotriol ointment was superior to betamethasone valerate ointment in psoriasis vulgaris. Though long-term results are not yet available, calcipotriol holds great promise as an antipsoriatic agent.

Administration, Topical↗
PubMed1990

Contact dermatitis from Naphthol AS.

Naphthol AS, a coupling agent in cotton dyeing, caused allergic contact dermatitis in 5 patients, sensitized from wearing a special kind of shirt. Patch tests with Naphthol AS and pieces of shirt were positive in all 5 patients. Analysis of 1 of the shirts revealed the presence of Naphthol AS. 1 patient with hand dermatitis and positive patch tests to Naphthol AS and nickel was a needlewoman, probably sensitized to Naphthol AS from occupational contact with clothes.

Clothing↗
PubMed1989

Efficacy of topical treatment in psoriasis with MC903, a new vitamin D analogue.

In 10 in-patients with chronic plaque psoriasis, the antipsoriatic effect of MC903, a new synthetic analogue of vitamin D was evaluated. In each patient two symmetrical located psoriatic plaques were selected for the study. Topical treatment with MC903 cream (containing 1.2 mg MC903 per g cream) was compared with placebo cream in a double-blind, controlled, left-right, randomized way during 6 weeks of therapy. Compared with baseline, the clinical (erythema, scaling and infiltration) improvement was significant after 1 week of therapy with MC903 cream, while lateral comparison showed MC903 cream significantly better than cream base after 4 weeks of therapy (p less than 0.05). Measurements of skin blood flow by the laser Doppler technique in evaluating the disease activity was not superior to the clinical assessments. In 3 patients the psoriatic lesions treated with MC903 cream cleared completely during 6 weeks of therapy. No essential adverse reactions were observed. MC903 has a potent effect on cell proliferation and cell differentiation, but has minimal effect on calcium metabolism. It is concluded that this synthetic vitamin D analogue is potentially useful in the treatment of psoriasis.

Administration, Topical↗
PubMed1988

Purpuric contact dermatitis from black rubber chemicals.

Black rubber chemicals are capable of causing an allergic contact dermatitis, in some cases associated with a purpuric capillaritis. A typical case of such a purpuric reaction is described in a man sensitive to black rubber chemicals.

Aged↗
PubMed1987

Is it possible to work with pao ferro (Machaerium scleroxylum, Tul.)?

Pao ferro (Machaerium scleroxylum), used as a rosewood substitute, is a strong sensitizer capable of causing acute outbreaks of allergic and irritant dermatitis in workers not previously exposed to it. This, however, has not prevented furniture factories from using the product. Apparently, most workers develop tolerance to the wood.

Benzoquinones↗
PubMed1986

Patch test sensitivity to Kathon CG.

Among 1511 consecutive patients patch tested with Kathon CG at 100 ppm active ingredient, 13 (0.8%) gave a positive reaction. Use test with a lotion containing Kathon CG (8.6 ppm) revealed no reaction in 11 patients with a positive patch test. It is concluded that a positive patch test reaction to 100 ppm does not initiate eczema after use of products preserved with Kathon CG in the low concentrations (3-15 ppm) used in final products.

Adult↗
PubMed1985

Pressure onycholysis in slaugtherhouse workers.

Onycholysis was found in 7 workers engaged with manual skinning of cattle. In all of them the nail problems started shortly after employment. The most likely explanation for the persistent onycholysis is work related pressure anoxia of the nailbed.

Abattoirs↗
PubMed1985

Multicenter clinical evaluation of a hydrocolloid dressing for leg ulcers.

The need for a moist environment for the normal healing process led to the development of occlusive dressings. Results from this study support the contention that a moist wound environment is favorable to the healing process in humans as well as in animal models. Hydrocolloid dressings are effective in the practical daily management of chronic and even refractive ulcerations of the lower extremities and offer a time-saving treatment alternative with a high degree of patient acceptability.

Adolescent↗