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Biomedical subjects

J Ressl

Publications and source records attributed to J Ressl.

At least 37 records · Page 2Linked to original sources

Pulmonary circulation in juvenile hypertension.

In 28 juvenile hypertensives (mean age 24 years) central haemodynamics was investigated at rest and during exercise. Hypertensives had significantly higher diastolic pulmonary artery pressure at rest than controls. Pulmonary diastolic pressure increased in parallel with cardiac output during exercise in hypertensives, in controls there was no relationship of pulmonary wedge pressure to cardiac output. Patients with diastolic pulmonary artery pressure higher than 12 mmHg at rest, or higher than controls during exercise, showed also signs of left ventricular hypertrophy on the ECG and/or X-ray. Those who were hyperkinetic and had systemic blood pressure greater than or equal to 150/90 at rest, had also significantly higher mean pulmonary artery pressure at rest. A correlation between total pulmonary, as well as pulmonary vascular and systemic resistances has been found at rest and during exercise in hypertensives; in controls, there was a correlation between the total pulmonary, as well as pulmonary vascular, and systemic resistances at rest; during exercise there was a correlation between total pulmonary, as well as postcapillary pulmonary and systemic resistances.

Adolescent↗

Haemodynamics in juvenile hypertension at rest and during exercise.

In twenty-eight patients with juvenile hypertension haemodynamic examinations were made at rest and during exercise (600 kpm/min). The cardiac output was determined by the Fick method; venous blood was sampled from a floating catheter introduced into the pulmonary artery; the systemic pressure was measured directly in the brachial artery. In 57% of the juvenile hypertensives the resting cardiac index was higher than 4.5 l/min/m2. The increase was due to an increase in the stroke volume rather than in the heart rate. Of the patients 37.5% had increased cardiac output relatively to the oxygen uptake also during exercise; most of them were hyperkinetic already at rest. The resting systemic resistance was significantly elevated in patients whose resting systolic pressure was greater than 150 mmHg and/or diastolic pressure was greater than 90 mmHg, compared to controls; during exercise the values of systemic resistance lay within normal limits. The systemic pressure responded to the exercise by either a hypertonic or a normotonic reaction. In only 23% of subjects normotensive at rest a hypertonic response to exercise was found.

Adolescent↗

Echocardiography of ruptured aortic valvular leaflet.

An echocardiographic finding presenting itself as a ruptured noncoronary aortic cusp is described. The basic finding included a constant diastolic echo separation of the right coronary and noncoronary cusps, noncoronary cusp prolapse in the direction of the posterior aortic wall and its high-frequency diastolic flutter. The diagnosis was confirmed at autopsy. The case study reaffirmed the clinical value of echocardiography which was the only technique, including the invasive ones, permitting to make an accurate morphological diagnosis.

Adult↗

Doppler echocardiography in diagnosis of mitral insufficiency.

By means of pulsed Doppler echocardiography (PDE) the authors investigated 53 patients who subsequently underwent heart catheterization and left ventriculography. The results of PDE examination agreed with ventriculography in 29 out of 31 patients with mitral regurgitation (PDE sensitivity = 94%). In 22 patients with no angiographic evidence of mitral regurgitation PDE exhibited two false positive results (PDE specificity = 91%). A semi-quantitative assessment of regurgitation by predetermined PDE criteria was successful in differentiating a group of severe mitral insufficiency (MI) from less significant MI (= mild and moderate MI angiographically). The agreement with ventriculographic classification of MI was 87 and 86%, respectively. The presented results clearly indicate that PDE, as a non-invasive methods, is precise enough in detecting mitral regurgitation and can be recommended for application in adult cardiology.

Doppler Effect↗

The effect of propranolol on left ventricular function at rest and during exercise in patients with ischemic heart disease.

Twelve patients with ischemic heart disease were investigated by right and left heart catheterisation. All patients were studied at rest and during exercise, both before and after administration of beta-blocker propranolol, Inderal (ICI). Left ventricular function decreased after administration of propranolol, but these changes were significant only during exercise. Contractility was depressed after administration of propranolol already at rest. On the other hand, left ventricular filling pressure decreased after administration of propranolol. Our results show the poor reliability of the evaluation of the left ventricular function based solely on the left ventricular filling pressure.

Aged↗