Biomedical subjects
Publications and source records attributed to J Reddy.
Five patients developed vitamin K-related abnormalities in blood coagulation during treatment with parenteral cephalosporin or cephamycin antibiotics. All the patients had significantly impaired renal function and complicated medical problems. The coagulation defect was corrected with vitamin K therapy.
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In an attempt to prevent postoperative sequellae dentists often prescribe penicillin or other antibiotics following periodontal surgery. A review of the literature shows conflicting reports about this procedure. This study investigated the efficacy of prophylactic penicillin in 19 human subjects undergoing periodontal surgery. Following initial therapy, flap surgery was undertaken in at least two comparable quadrants in each patient. Using a split mouth technique, patients were either given phenoxymethyl penicillin or a placebo following flap surgery for 5 days. Pain, infection, plaque levels, gingivitis and crevicular fluid flow were measured during a 4 week period. There were no differences between the placebo or penicillin sides in any of the parameters studied, except that the pain experience was significantly lower on the penicillin operated side. Within the limitations of this study it is difficult to substantiate the routine use of antibiotics following periodontal surgery.
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A young male Caucasian with an 18 month history of systemic sarcoidosis presented with a major cardiac rhythm disturbance which could only be attributed to cardiac involvement.
Two patients were admitted with the provisional diagnosis of ischaemic heart disease. Both patients had lumbar punctures and the final diagnosis of subarachnoid haemorrhage with complicating cardiac arrhythmias was made in both cases.
A case of Listeria monocytogenes septicaemia with meningitis is described. Predisposing factors in this case included chronic liver disease, diabetes mellitus and liver malignancy. The infection responded poorly to ampicillin.
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The effectiveness of a commercially prepared oxygenating agent (Gly-Oxide Liquid) in reducing plaque accumulation and gingivitis was studied over a 3-week period. Sixty-nine dental students, ages 20 to 30, were divided into three groups: control (group I), placebo (group II), test formulation (group III). Subjects were scored using the Plaque and Gingival indices of Loe et al. at the beginning of the study and at 1, 2, and 3-week intervals. In accordance with a well-established experimental gingivitis model, oral hygiene was withdrawn for the duration of the study. No statistically significant differences in plaque development was noted. Analysis of variance showed a significant treatment effect on gingivitis (P less than 0.01). A significant difference between group I and group III was evident (P less than 0.05). The study indicates that the formulation may be effective in reducing gingivitis in human subjects. Additional investigations regarding its usefulness as a routine oral hygiene adjunct are warranted.
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Family screening for hyperlipoproteinaemia was undertaken when a patient presented with myocardial infarction in association with Type V hyperlipoproteinaemia. The clinical features of this unusual form of hyperlipoproteinaemia are discussed together with its frequency in the general population and in relatives of affected patients.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.