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Biomedical subjects

J Reddy

Publications and source records attributed to J Reddy.

At least 55 records · Page 3Linked to original sources
PubMed1984

Experience with the third generation cephalosporins, cefoperazone and cefotaxime: report.

The efficacy of the third generation cephalosporins, ceforperazone and cefotaxime, was evaluated in a provincial hospital in a small group of patients with severe infections. In one study, patients with severe sepsis were randomly allocated to a group receiving either cefoperazone or ampicillin (ticarcillin or cloxacillin) and gentamicin. In the other trial, a selected group of ill patients was given cefotaxime. Clinical and laboratory analyses showed that these two drugs are safe, well tolerated and effective in the blind treatment of severe infections.

Adolescent↗
PubMed1982

Calcium, phosphorus, fluoride, and pH levels of human dental plaque from areas of varying fluoride levels.

Plaque calcium, phosphorus, fluoride, and pH in samples obtained from 149 life-long resident children, aged from six to seven and 12 to 13 yr, from one of three naturally fluoridated communities were determined. In general, smaller amounts of phosphorus and fluoride, and larger amounts of calcium and hydrogen ions (lower pH values) are associated with smaller amounts of fluoride in the drinking water supply. Significant differences among the mean pH, fluoride, and Ca/P concentrations both in the six-to-seven- and 12- to 13-year age group were found when comparing the results of the three areas with different levels of fluoride in their drinking water supply.

Adolescent↗
PubMed1981

Renal biopsy: an appraisal of its role in clinical nephrology.

A study was undertaken over a period of one year to assess the place of percutaneous renal biopsy in clinical nephrology. During this time 83 patients were biopsied. In 76 patients (92 percent) renal tissue was obtained at the first attempt. In the other seven patients renal tissue was obtained on a repeat biopsy after ultrasonic localisation of the kidney. Adequate renal tissue for a full histological interpretation was obtained from 82 of the 83 patients. The commonest indications for biopsy were a suspected systemic disorder, persistent proteinuria with or without the nephrotic syndrome, and abnormal renal function. In 18 patients the provisional clinical diagnosis was shown to be incorrect, while in another 17 the diagnosis was made solely on histological grounds. In only seven patients was there no histological diagnosis made. A wide spectrum of renal lesions was seen and in 35 patients the renal biopsy findings had a significant influence on patient management. Five patients developed macroscopic haematuria and one a perirenal haematoma. Percutaneous renal biopsy performed by an experienced physician and having the support of an expert histopathology service is a safe and valuable diagnostic aid for patients with a wide spectrum of renal and systemic disorders.

Adolescent↗
PubMed1981

Cefoxitin-associated renal failure.

Two elderly women suffered an acute deterioration of renal function after treatment with cefoxitin sodium. One with stable chronic renal failure due to reflux nephropathy underwent a rapid deterioration of renal function which proved fatal. The other woman had rheumatoid arthritis and developed acute tubular necrosis after treatment with gentamicin and cefoxitin. All the data suggested that the antibiotic was responsible for the deterioration in renal function. The dose of cefoxitin should be reduced in patients with renal functional impairment. Cefoxitin should either be used with great caution or not prescribed in combination with aminoglycoside antibiotics.

Acute Kidney Injury↗
PubMed1981

The peripheral blood picture in thyrotoxicosis.

The haematological results of 200 patients with uncomplicated thyrotoxicosis is reviewed. Although more than half of the patients showed a normal blood picture, several abnormalities were detected. In 37 percent of patients the erythrocytes showed microcytosis, and 8.5 percent were mildly anaemic. An absolute lymphocytosis was found in 11 percent and neutropenia was present in 2.5 percent of patients. The prevalence of treated pernicious anaemia was 1.5 percent.

Adolescent↗
PubMed1981

Cefoperazone in the treatment of severe or complicated infections.

We report the use of cefoperazone in 62 cases of serious infection, most of which occurred in patients with renal impairment. 43 severe or complicated urinary tract infections, 11 cases of pneumonia and 8 with other severe sepsis were treated with cefoperazone 1 to 2 g twice daily usually for 5 to 10 days. Of the patients with urinary tract infection, all who were symptomatic showed a rapid clinical response; 26 (61%) were cured including 11 of 16 with chronic renal failure; 12 relapsed and 5 were reinfected with a different pathogen. All of these patients were infected by organisms sensitive to cefoperazone by disc testing but in 5 of those who relapsed the cefoperazone MIC was in fact greater than or equal to 50 microgram/ml. Ten of 11 cases with radiologically confirmed pneumonia were cured with cefoperazone. 7 episodes of pneumonia were in patients with end-stage chronic renal failure (6 were on dialysis) and 1 was in a patient with acute renal failure. Seven of 8 cases with severe sepsis were cured with cefoperazone. 1 patient was withdrawn from the study when acute bronchospasm followed a 2 g intravenous dose. 2 of the successfully treated patients had functioning renal transplants, 2 of 3 with severe chronic renal failure were on dialysis and 1 had acute renal failure. Side effects included minor disturbances of liver function in 6 patients (11%), diarrhoea in 7 (13%) and marked alcohol intolerance in one, 4 patients with chronic renal failure developed a coagulation disorder which was corrected with vitamin K. None of the patients showed deterioration in renal function while receiving cefoperazone. Cefoperazone promises to be an effective drug for the treatment of a wide spectrum of severe infections in hospitalised patients including those with impaired renal function.

Adolescent↗