Search PubMed⌕ Search

Biomedical subjects

J Ranft

Publications and source records attributed to J Ranft.

50 records · Page 3Linked to original sources
PubMed1987

In vivo capillary microscopy findings and ophthalmoscopy findings in scleroderma.

We used in vivo capillary microscopy to examine the nailfold capillaries of 19 patients with scleroderma (18 women and 1 man; average age 56.6), and compared these findings with those obtained using an ophthalmoscope. The ophthalmoscope revealed hemorrhages in 68% of the patients, a reduction in the number of capillaries in 79%, avascular areas in 79%, and dilated capillaries in 84%. The findings from ophthalmoscopy showed a correlation of approximately 80% with those from capillary microscopy. Since the diagnosis of scleroderma can be confirmed with this instrument, we suggest that it be used when microscopy equipment is not available.

Adult↗
PubMed1987

[Transcutaneous measures of oxygen partial pressure and capillaroscopic parameters as affected by naftidrofuryl in patients with obliterative arteriopathies, Fontaine stages II-IV].

Transcutaneous partial oxygen pressure on dorsum of foot was determined and capillaroscopy of big toes performed before and after infusions of naftidrofuryl (200 mg/l/h) and of 5% levulose to 30 patients with obliterative arterial disease of lower limbs, stages II to IV (10 patients in each stage). Naftidrofuryl provoked an increase in cutaneous partial oxygen pressure of 26.8 to 36.4 mm Hg (p less than 0.001) whereas no significant change was noted after 5% levulose. In addition, density of visible capillaries increased from 23.5 to 26.1/mm2 with naftidrofuryl. Severe stages of ischemia, evaluated as described by Fagrell, were improved by naftidrofuryl treatment. These findings suggest a favorable action of naftidrofuryl on cutaneous microcirculation distal to arterial obliteration at all Fontaine's stages.

Aged↗
PubMed1987

[Vital capillary microscopy and with ophthalmoscope-detected findings in progressive systemic scleroderma].

Nineteen patients suffering from scleroderma (average age 56.6 years; 18 women, 1 man) were examined by in vivo capillary microscopy of the nail fold. The possibility of achieving results with the ophthalmoscope was examined. The correspondence between ophthalmoscopic and television microscopic results was evaluated. With the ophthalmoscope hemorrhages were found in 68% of the patients, reduction in the number of capillaries in 79%, avascular areas in 79%, and dilated capillaries in 84%. The correspondence between the findings of the two methods was 80% and more, so that examination of the nail fold capillaries with an ophthalmoscope can help to verify the diagnosis of scleroderma. This method should be employed whenever scleroderma is suspected and microscopical equipment is not available.

Adult↗
PubMed1986

In-vivo capillary-microscopical findings in patients with thrombangiitis obliterans, progressive systemic scleroderma, and rheumatoid arthritis, respectively.

Fourty patients with thrombangiitis obliterans were examined to find out whether in-vivo capillary microscopy can contribute to the establishment of a diagnosis. No capillary-microscopical signs could be detected that are exclusive to thrombangiitis obliterans. Nevertheless typical signs as capillary lengthening, capillary branching (53%) and haemorrhagic margin (75%) are of considerable differential-diagnostic value when it comes to distinguishing a case of thrombangiitis obliterans from a case of degenerative arterial occlusive disease. In a further series of examinations, the nailfold area of patients with progressive systemic scleroderma was examined by in-vivo capillary microscopy and with an ophthalmoscope. The coincidence of the findings between the two methods was 80% and more, so that the examination of the nailfold capillaries with an ophthalmoscope can aid verify the diagnosis of scleroderma. In patients with rheumatoid arthritis capillary tortuosities (85%), capillary branching (53%) and increased venule visibility (55%) often occur. These are unspecific signs. Typically capillary-microscopical symptoms for the disease are not detectable.

Adult↗
PubMed1986

Laser-Doppler examinations in persons with healthy vasculature and in patients with peripheral arterial occlusive disease.

Recently, a new procedure for noninvasive measurement of the microcirculation has been developed in the form of a helium-neon-laser Doppler apparatus with which the total erythrocyte flow through a cubic millimeter of skin is quantifiable. The authors used the procedure to examine 17 persons with healthy vessels, 36 patients with a degenerative occlusive disease of the peripheral arteries in Fontaine stages II-IV, and 5 patients with endangiitis obliterans. It is concluded that single measurements do not permit an assessment of microcirculatory conditions but that provocative tests (which are described), especially occlusion tests, make possible valid and reproducible statements and have a high selectivity with respect to the different stages of disease. By repeated measurements followed by calculation of mean values, a further reduction in intraindividual variability among the measurement results can be obtained. Laser-Doppler examinations of the skin constitute a new procedure with which quantitative statements on the blood flow through skin are feasible and from which interesting results can be expected, especially when used as an acute test.

Aged↗
PubMedDate not supplied

Frequency of malignant diseases in deep venous thrombosis of the lower extremities.

A retrospective investigation was carried out in a total of 200 patients (100 women, 100 men) with an average age of 61.0 years (19-97 years) with a phlebographically verified deep vein thrombosis of the lower limbs. It was examined whether and how frequently acute phlebothromboses are associated with a malignant underlying disease not detected up to that time. Specific diagnostics showed that a malignancy could be detected in 11.5% of all patients. As expected, the number of freshly discovered malignant diseases rose with increasing age. Seventy-one percent of all patients with a phlebothrombosis and a simultaneous tumor condition were more than 60 years old. The results clearly show that screening for occult malignant diseases should be carried out systematically and routinely in patients with etiologically unclear acute deep vein thromboses, at least from the 50th year of life onwards.

Acute Disease↗