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Biomedical subjects

J Ranft

Publications and source records attributed to J Ranft.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Location and morphology of plaque of the carotid artery and femoral artery in the B-scan image in employees of the Düsseldorf public officials: value of screening study].

With the help of high-resolution real-time sonography, we examined the carotid and femoral arteries in 3,500 asymptomatic persons to assess early states of atherosclerosis an to prove the utility of B-Scan-Sonography in this aim. We found 384 people having plaques, totally 769 pl. 68 p.c. of all plaques we were found in the femoral arteries, 32 p.c. in the carotid arteries, in each case with preference of the bifurcation and the pre-bifurcation-region. This seems to confirm earlier studies on this theme. As regards to the morphology, we found 67 p.c. (of all plaques) being faintly-echogenic ("fatty-streaks" or intermediär type). 73 p.c. of all plaques showed a smooth or faintly irregular surface-character. More than 75% of all plaques had a volume less than 0.3 ccm. Altogether, the results verify the assessment of mostly early states of atherosclerosis with the help of real-time-ultrasound and underline this method being a good and sufficient non-invasive-technique for screening-examinations on an asymptomatic collective.

Arterial Occlusive Diseases↗
PubMed1991

[Arteriosclerosis vascular changes as an expression of the local effect of mechanical continuous stress--observations of the femoral artery of marathon runners].

The arteries of the thigh of 126 male marathon runners at the age of 41.6 +/- 11.3 years were examined with B-Scan-ultrasound. 32 (62.1%) persons were found with arteriosclerotical plaques. All of them were older than 35 years, so the number of arteriosclerosis in this group increases to 36.4 percent (n = 88). 38 persons were younger than 35 years. Persons with plaques started training about 10.9 years later than those without plaques. Correlations of plaques and age, age of starting training, years of training and km/year were found. The numbers of riskfactors showed significant differences between both groups but the correlation of "having no risk factor" and arteriosclerotical plaques was higher than the correlations of nicotine, hypertension, hypercholesterolemia and plaques. It seems that marathon running itself is a risk factor of developing arteriosclerotical plaques in the femoral arteries particularly if the age of starting training is higher than 30 years.

Adult↗
PubMed1991

[Prevention of arterial and venous vascular diseases, especially the correlation between risk factors and arteriosclerosis].

In a epidemiological study 3840 clerks of state of North Rhein Westfalia were investigated concerning the frequency of atherosklerotic leasions of the carotid and femoral arteries in duplex scanning. 17% of all investigated showed independency to age, sex and risk factors alterations of the vessel walls. Men had twice as much plaques as women and male subjects with multiple risk factors had four times more plaques than those without.

Adult↗
PubMed1991

[Imaging real-time sonography (B-scan) of peripheral veins--possibilities for use with reference to secondary prevention].

In 2400 male and 1400 female persons the proximal femoral and saphenal venous vessels have been monitored and measured with a Ultramark 4, build by ATL, by use of 7.5 megacycle/s. transducer. Moreover, we took the venous calibers at the junction of the saphenous veins into femoral veins. In patients with marked varices or less symptomatic patients as well as clinically asymptomatic persons with positive family history there could be found significantly bigger dilatation of vessel calibers in those patients laying than those standing up, in contrast to healthy persons. B-Scan ultrasound consequently in future offers a new range of diagnostic values in examination of venous vessels, that is to say a non-invasive, reproducible and haemodynamically tolerable method which helps to improve secondary prevention.

Female↗
PubMed1991

[Silent myocardial ischemia and arrhythmia in patients with stage II-IV arterial occlusive disease].

Holter-monitoring offers a possibility to detect asymptomatic coronary-heart-disease-patients, suffering from peripher-arteric-occlusion stadium II-IV, and introduce them to effective medication. It became evident, that about 30% of all patients with unknown coronary-heart-disease, even as patients who were therapied against coronary-heart-disease, have had silent myocard ischemia.

Arterial Occlusive Diseases↗
PubMed1991

[Duplex procedure in prevention of arteriosclerosis].

Early atherosclerosis can be easily dedected in arteries accessable to ultrasound. The main localisations are the carotid and femoral arteries, which can be deseased alone or together. The progression seems to be higher in the femoral vessels. There is the impression that the growth can be influenced by drugs which lower blood cholesterol or are partial inhibitors of serotonin receptors (S 2).

Adult↗
PubMed1991

[Controlled long-term blood pressure measurement with intravenous prostaglandin E1 infusion].

In a placebo-controlled, double-blind study and a follow-up open study with 48 patients between 22 and 87 years of age with peripheral occlusive arterial disease in Fontaine's stage II and IV, the systolic, diastolic and mean pressure and heart rate were studied during intravenous infusion of 40 mcg prostaglandin-E1. This normal therapeutic dose did not have any clinical relevant effect on the blood pressure or cause any significant changes versus placebo in the individual variables measured. Local irritation involving the veins was observed in 6 patients, 1 patient dropped out because of nausea.

Alprostadil↗
PubMed1989

[PGE1 in senile macular degeneration. A pilot study].

To determine whether PGE1 can improve retinal function a pilot study was carried out with seven patients (five women and two men) aged between 70 and 76 years who were suffering from a dry senile macular degeneration. The intravenous infusions of two ampoules of Prostavasion (PGE1) were given twice a day (infusion time: 2 hours per infusion) over three to five weeks (average four weeks). Retinal function was determined before and after treatment and finally again three months later one the basis of five criteria (subjective visual capacity, visual acuity, foveal threshold, static perimetry). The study showed that the subjective visual capacity had increased in six of the seven patients, the sensitivity of the foveal threshold in five, the average retinal sensitivity in two, and the average macular sensitivity in one. These results show that PGE1 probably has a therapeutic effect in the treatment of dry macular degeneration and that controlled studies make sense.

Aged↗
PubMed1988

[The status of laser Doppler examination in patients with arterial occlusive disease].

Adequate skin perfusion is one of the most important prerequisites for healing of trophic lesions and amputation wounds in patients with peripheral arterial disease. The discrepancies possible between macro- and microcirculations stress the necessity of new methods for assessment of terminal vascular beds. With laser-Doppler flowmetry, in addition to determination of transcutaneous oxygen partial pressure and capillary microscopy, a noninvasive method is provided for clinical evaluation of the cutaneous microcirculation. Even though the description of the method and the initial investigative results have been available for more than ten years, the diagnostic usefulness of the procedure remains to be clearly established. This may be primarily due to the fact that current examination methods such as Xenon-133-clearance, photoplethysmography and skin temperature measurements are not relevant reference standards and that there is a paucity of fundamental work with respect to reproducibility and validity of laser-Doppler flowmetry as well as, to some degree, because of discrepancies generated by varying examination techniques, differing sites of examination, non-standardized examination parameters and accordingly non-comparable study results from different working groups. Part of the difficulty is also attributable to the structural complexity, physiologic fluctuations of erythrocyte flow velocity and the morphologic differences with respect to the site of examination. The measurement principle is based on registration of refraction, reflection and partial absorption of the emitted 2 mW He-Ne laser signal (wave length 632.8 nm) in the tissue being examined. An output signal, in volts, is created which is proportional to the product of the number of moving cells and their mean velocity. The housing of the laser-Doppler probe is fitted with a heating element. Accordingly, thermostatic measurements can be carried out with a temperature between 28 and 44 degrees C. The depth of penetration of the laser-Doppler signal is about 0.7 to 1 mm such that a tissue hemisphere of approximately 1 mm can be examined. The relative portion of the signal derived from the arterioles, capillaries, arteriovenules and arteriovenous anastomoses as well as the venules cannot be differentiated. While in-vitro experiments with flow models have shown a linear correlation between erythrocyte flow and laser-Doppler signals, in-vivo measurements are encumbered by skin pigmentation, thickness of the epidermis, capillary morphology and capillary number, hemoglobin content and angle of incidence of the laser-Doppler signal.(ABSTRACT TRUNCATED AT 250 WORDS)

Arm↗