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Biomedical subjects

J R Thompson

Publications and source records attributed to J R Thompson.

At least 307 records · Page 17Linked to original sources
PubMed1976

Adult arteriosclerotic moyamoya.

Progressive idiopathic distal internal carotid artery occlusion in children and young adults associated with the development of bridging channels and tortuous, plethoric intracerebral arterial networks has been termed moyamoya or Nishimoto's disease. It is now generally recognized that this unusual angiographic patten results from collateral supply pathways and is not a primary angiomatous process. The authors describe 2 middleaged patients with intracranial arteriosclerotic occlusive lesions demonstrating secondary collateral patterns angiographically identical to moyamoya.

Carotid Artery, Internal↗
PubMed1976

Cerebral arterial dolichoectasia with seizure. Case report.

Cerebral angiography, performed after a seizure in a patient with a life-long history of typical hemiplegic migraine, disclosed markedly dolichoectatic anterior and middle cerebral arteries. No abnormality of the adjacent capillary or venous structures was present. A positive brain scan was attributed to ischemia induced by vasospasm rather than to the corresponding large tortuous anterior and middle cerebral arteries. There were no permanent sequelae and the patient has been free of seizures on Dilantin and phenobarbital over a 3-year follow-up period. Angiographic demonstration or description of a similar ectatic set of anterior and middle cerebral arteries could not be found in the literature. The concurrence of seizures and hemiplegic migraine adds to the peculiarity of this case.

Adult↗
PubMed1975

Effect of glucose load on synthesis of plasma glucose in lactating cows.

We assess the effect of an intravenous glucose load on production of glucose in lactating dairy cows. Isotope dilution techniques were utilized to measure transfer rate of plasma glucose (with tritiated glucose) and gluconeogenesis (with carbon-14 labeled propionate or carbon dioxide). A glucose load equivalent to the cow's normal transfer rate decreased endogenous glucose output two-thirds and decreased gluconeogenesis by half. Glucose concentration and transfer rate were higher within 2 h after glucose load started while carbon-14 transfer to plasma glucose became increasingly depressed and persisted for at least 1 h after loading terminated. Reduced plasma glucose synthesis from propionate during loading was associated with increased transfer of propionate carbon to plasma phospholipids, triglycerides, and cholesterol esters, and with increased plasma insulin concentration. It appears that glucogenic precursors are utilized for greater synthesis of lipid (and presumably glycogen) and that loading leads to metabolic changes causing net reduction in gluconeogenic capacity. These changes could have important implications for use of intravenous glucose in treating hypoglycemic metabolic conditions.

Animals↗