Search PubMed⌕ Search

Biomedical subjects

J R Graham

Publications and source records attributed to J R Graham.

At least 73 records · Page 4Linked to original sources
PubMed1985

MacAndrew Scale and sociodemographic correlates of adolescent alcohol and drug use.

To assess the utility of the MacAndrew Scale (MAC) of the MMPI as a screening device for problem drinking and drug use with adolescents, 403 ninth- through twelfth-graders were administered the MAC, a sociodemographic questionnaire, an alcohol/drug frequency questionnaire, the Adolescent Alcohol Involvement Scale, and the Adolescent Drug Involvement Scale. Stepwise multiple regression analyses showed the MAC to be the best single predictor (compared to sociodemographic variables) of alcohol/drug use for both males and females. MAC cutoff scores for differentiation between alcohol/drug abusers and nonabusers were obtained that were more efficient than base rate prediction. The results are discussed as supportive of the MAC's concurrent validity and of Jessor and Jessor's "problem behavior theory." Finally, implications for practice (e.g., early intervention and prevention) and future research are considered.

Adolescent↗
PubMed1985

Forty-five years of migraine--observations and reflections "from the inside" by a physician-patient.

A case is presented of severe migraine observed by a physician-patient for 45 years from the age of 27 to 72. A system was developed of grading headache frequency and severity which has permitted, over the last 33 years, a semi-quantitative analysis in terms of quarter years of: the course of the disease, the results of various treatments, and the associated psychological tensions. The patient's mother and other family members of four generations had migraine. The frequency and severity of the patient's headaches increased over 22 years to a peak that coincided with his maximal professional work-load; they then receded and disappeared during the last 11 years of retirement. In the first 13 years of no prophylactic treatment a periodicity was present with a median span of 2.4 weeks. In these first 13 years, there was a left-sided preponderance of attacks. It is concluded that migraine is a complex disturbance comprising a genetic defect with an inbuilt biorhythm and a threshold for manifestation of headache sensitive to many physical, physiologic, and psychologic factors of stress in the life of the patient.

Adult↗
PubMed1985

Effect of ketanserin on blood pressure and biochemical parameters in patients with essential hypertension.

Seventeen subjects with essential hypertension (14 men, 3 women, 40-69 years of age), 13 of whom continued their previous antihypertensive therapy, completed a double-blind crossover trial of ketanserin 40 mg twice daily versus placebo tablets twice daily. Each treatment phase was 6 weeks in duration. For the group as a whole, blood pressure (BP) was reduced in the ketanserin phase compared with the placebo phase: supine mean BP decrease: 4 +/- 1 mm Hg (p less than 0.05); standing mean BP decrease: 7 +/- 1 mm Hg (p less than 0.001). Heart rate (HR) was also significantly decreased in the ketanserin phase (5 +/- 1 beats/min) (p less than 0.001). When individual subgroups were analysed, the reductions in BP and HR were greater in subjects already receiving antihypertensive therapy, diuretics, and/or beta-adrenergic blockers. Changes were observed in 24-h urine sodium and potassium excretion: Sodium (mmol/day): placebo 137 +/- 17, ketanserin 174 +/- 19 (p less than 0.05); potassium (mmol/day): placebo 74 +/- 8, ketanserin 57 +/- 5. For the group as a whole, there were no significant adverse effects during the ketanserin phase, although two subjects had a dose reduction of ketanserin because of drowsiness and dizziness. Two additional subjects withdrew from the study owing to adverse effects, one in the placebo phase. In conclusion, ketanserin in the dose administered has a modest hypotensive effect, which is best seen in subjects already receiving other antihypertensive agents.

Adrenergic beta-Antagonists↗
PubMed1985

Interpretation of moderately elevated MMPI scores for normal subjects.

Two opposing views concerning the interpretation of moderately elevated MMPI scores of normal subjects have appeared in the literature. Whereas some authors have suggested that such scores indicate negative characteristics less severe than those suggested by more extremely elevated scores for psychiatric patients, other authors have suggested that such scores may be indicative of more positive characteristics. The present study attempted to determine the relative validity of these two opposing views. Correlates of MMPI clinical scales were determined for 101 male and 101 female college students who had no clinical T-score greater than 75. Subjects described themselves using the Adjective Check List (ACL), and they were also described by peers using the ACL. Point-biserial correlations between MMPI scores and self and peer endorsements on the ACL were computed. For both self and peer data more significant correlations were found than expected by chance. Most of the correlates involved negative characteristics, offering some support for the interpretive approach based on an attenuation of negative descriptors derived for psychiatric patient samples.

Adult↗
PubMed1984

Age-related headache characteristics.

A computerized headache interview was completed by 255 children, adolescents, and adults. Children did not differ from adults in the frequency of auras or prodromes. Young children were more likely than older patients to have brief headaches and headaches that tended to occur on weekdays, and to feel "great" after a headache. They were less likely than older patients to acknowledge multiple kinds of headaches, headaches located on one side of the head or posteriorly, and such concomitant occurrences as blurring, photophobia, irritability, frustration-anger, light-headedness, trouble with concentration, numbness-tingling, and lack of appetite. We do not know how much these differences can be attributed to age-related differences in language, physiology, or medical care selection factors.

Adolescent↗
PubMed1984

Chronic paroxysmal hemicrania. VII. Mechanical precipitation of attacks: new cases and localization of trigger points.

Two new chronic paroxysmal hemicrania patients are described. In both, attacks can be precipitated mechanically by applying firm manual pressure to certain sensitive points on the neck, i.e. in the C2 area, in the transverse processes of the C4-C5 vertebrae, or beneath the posterior part of the skull on the symptomatic side. The most sensitive area seems to be the transverse process of C4-C5. Susceptibility to this type of attack is dependent on the flow of spontaneous attacks; attacks are easily precipitated in a phase with multiple spontaneous attacks, but are not readily precipitated otherwise. Under indomethacin protection, local tenderness is clearly diminished and attacks cannot be precipitated.

Adult↗
PubMed1984

Effects of indomethacin, sulindac, naproxen, aspirin, and paracetamol in treated hypertensive patients.

Four placebo controlled, randomised crossover studies were carried out to investigate the effects of non-steroidal anti-inflammatory drugs and analgesics on blood pressure control in treated hypertensive patients. Twelve patients completed one study comparing indomethacin, 25 mg tds, with placebo in 2 six week phases; there were increases in mean blood pressure (p less than 0.01) of 9 mm Hg (casual), 8 mm Hg (supine) and 10 mm Hg (standing) in the indomethacin phase accompanied by a 50% reduction in plasma renin activity (p less than 0.05) and a 47% decrease in plasma aldosterone concentration (p less than 0.05). Similar studies on aspirin-SR, 650 mg daily (19 patients), and paracetamol, 1 g 8th hourly (20 patients), revealed only small changes in blood pressure, with a 2 mm Hg increase in supine diastolic blood pressure during aspirin therapy and a 4 mm Hg increase in supine and standing systolic blood pressure during paracetamol therapy (p less than 0.05 for both). Nineteen patients completed a study with 4 three week phases, taking placebo, naproxen 250 mg mane and 500 mg nocte, sulindac 200 mg bd, and aspirin-SR 1950 mg bd. All three active agents depressed plasma renin activity and plasma aldosterone concentration. Neither sulindac nor aspirin caused any significant increases in blood pressure, and naproxen had little effect, though it did cause a 4 mm Hg increase in standing systolic pressure (p less than 0.05). We conclude that the effects of indomethacin on control of blood pressure in treated hypertensive patients are not exhibited to the same extent by other drugs investigated, and that they are not dependent on the concomitant decreases in plasma renin activity or plasma aldosterone concentration. The importance of inhibition of prostaglandin synthesis remains unclear.

Acetaminophen↗
PubMed1984

The effect of ketanserin on blood pressure and biochemical parameters in treated patients with essential hypertension.

17 subjects with essential hypertension (14 male, 3 female - ages: 40-69 years), 13 of whom continued their previous anti-hypertensive therapy, completed a double-blind cross-over trial of ketanserin 40 mg twice daily versus placebo tablets twice daily - each treatment phase was six weeks in duration. For the group as a whole, blood pressure (BP) was reduced in the ketanserin phase compared with the placebo phase; supine mean BP decrease: 4 +/- 1 mm Hg (p less than 0.05); standing mean BP decrease: 7 +/- 1 mm Hg (p less than 0.001). Heart rate (HR) was also significantly decreased in the ketanserin phase by 5 +/- 1 beats/minute (p less than 0.001). When individual subgroups were analysed the reductions in BP and HR were greater in subjects already receiving anti-hypertensives, diuretic and/or beta blockers. Changes were observed in 24 hour urine sodium and potassium excretion - sodium (mmol/day): placebo 137 +/- 17, ketanserin 174 +/- 19 (p less than 0.05); potassium (mmol/day): placebo 74 +/- 8, ketanserin 57 +/- 5. For the group as a whole there were no significant adverse effects during the ketanserin phase, although two subjects had a dose reduction of ketanserin because of drowsiness and dizziness. Two additional subjects withdrew from the study due to adverse effects, one in the placebo phase. In conclusion ketanserin in the dose administered has a modest hypotensive effect which is best seen in subjects already receiving other anti-hypertensive agents.

Adrenergic beta-Antagonists↗
PubMed1983

Phycobilisome composition and possible relationship to reaction centers.

The photosynthetic apparatus was studied in Anacystis nidulans wild type and in a spontaneous pigment mutant 85Y which had improved growth in far-red light (greater than 650 nm). Two phycobiliproteins, C-phycocyanin (lambda max 625) and allophycocyanin (lambda max 650), were present in a molar ratio of approximately 3:1 in the wild type and approximately 0.4:1 in the mutant. Phycobilisomes of wild type cells were larger (57 X 30 nm) than those of the mutant 85Y (28 X 15 nm). In the mutant they seemed to consist primarily of the allophycocyanin core. Fluorescence emission maxima of wild type and mutant 85Y phycobilisomes were at 680 nm (23 degrees C) and 685 nm (-196 degrees C). Excitation maxima of phycobilisomes were at 630 and 650 nm for the wild type and the mutant 85Y, respectively. The phycobilisomes of wild type cells whether grown in white or far-red light had the same size and pigment composition. A typical wild type cell in white light had a thylakoid area of 22.8 microns 2, but in far-red light the area was reduced to 13.5 microns 2, which was close to that of 85Y at 13.6 microns 2. Chlorophyll molecules per cell decreased in far-red light from 1.1 X 10(7) in wild type (white light) to 4.5 X 10(6) in mutant 85Y (far-red). The number of phycobilisomes per cell (approx 2 X 10(4)), calculated from the phycobiliprotein content and phycobilisome size, was about the same in wild type (white light) and mutant 85Y (far-red light), but the number of phycobilisomes per unit area of thylakoid was significantly greater in mutant 85Y than in wild type. The present results suggest that the phycobilisomes are linked with reaction centers and that the PSII complement (photo-system II and phycobilisome) was fully maintained in far-red light.

Binding Sites↗
PubMed1983

On the Ratio of Photosynthetic Reaction Centers RC2/RC1 in Chlorella.

Chlorella pyrenoidosa (Emerson strain) was grown under high and under low irradiance. Measurements of the O(2) flash yield and the P700 absorption change gave estimates for the ratio of photoreaction centers RC2/RC1 at 1.2 to 1.5. A background light 1 did not increase flash yield.

Journal Article↗
PubMed1983

Outcome of eclectic psychotherapy in private psychological practice.

The outcome of eclectic psychotherapy in a private psychological practice was examined in 69 clients. Target symptoms, life-adjustment ratings, social-adjustment ratings, and therapy expectancy were obtained before and after four months of psychotherapy from clients, therapists, and independent clinical raters. Results indicated that significant change had occurred after four months of psychotherapy for 6 of 10 categories of target complaints, in 9 of 11 areas of life adjustment and in 14 of 22 areas of social adjustment. Overall, 70 percent of clients showed improvement in their symptoms; 14 percent were unchanged and 17 percent deteriorated. The major value of the study is an exploration of psychotherapy outcome under naturalistic conditions in a growing but rarely studied treatment setting.

Adult↗
PubMed1983

Marital interaction and adjustment in patients with essential hypertension.

Twenty-five men and twenty-six women with essential hypertension, and their spouses, were compared with normotensive control couples on a questionnaire measure of marital adjustment. The marriages of the hypertensive men showed significantly raised levels of marital dissatisfaction in the spouses, and an abnormal degree of reciprocal dissatisfaction between spouses. The marriages of the female patients showed an abnormal lack of reciprocity between spouses' scores. These findings support anecdotal reports of a relationship between marital disharmony and communication problems and elevated blood pressure. It is suggested that clinicians could routinely assess marital adjustment in patients with essential hypertension, and that in some cases conjoint marital therapy might be an adjunct or alternative to anti-hypertensive medications.

Adult↗
PubMed1982

Effects of once daily indapamide and pindolol on blood pressure, plasma aldosterone concentration and plasma renin activity in a general practice setting.

Sixteen patients with essential hypertension completed a double blind factorial trial comparing the effects of indapamide (2.5 mg daily) and pindolol (10 mg daily) on blood pressure, heart rate, plasma renin activity and plasma aldosterone concentration. There were four randomised test phases of eight weeks each during which patients received indapamide alone, pindolol alone, indapamide plus pindolol and no active treatment (placebo). Blood pressure and heart rate were measured every two weeks. Supine mean arterial pressure fell from 117 mm Hg in the placebo phase to 111 mm Hg in the indapamide phase, 106 mm Hg in the pindolol phase and 103 mm Hg in the combined indapamide plus pindolol phase. Factorial analysis confirmed that the hypotensive effects of the two drugs were additive, without evidence of potentiation or antagonism. Indapamide caused significant reductions in plasma potassium and chloride, and increases in plasma bicarbonate and urate concentrations; it also caused increases in plasma renin activity and aldosterone concentration. These changes are similar to those observed with thiazide diuretics.

Adult↗
PubMed1982

Protochlorophyll(ide) in a Blue-Green Alga.

During growth under far-red (>650 nm) light, Anacystis nidulans accumulates protochlorophyllide to concentrations about one-tenth of the chlorophyll. From whole cell fluorescence spectra, protochlorophyll(ide) was identified also in another blue-green, and in a red, alga grown in far-red light.

Journal Article↗