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Biomedical subjects

J R Graham

Publications and source records attributed to J R Graham.

At least 55 records · Page 3Linked to original sources
PubMed1989

Medicine in music.

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Anniversaries and Special Events↗
PubMed1988

Migraine and left-handedness: is there a connection?

In 1982, Geschwind and Behan reported an association between migraine headache and left-handedness. The present study was an attempt to test this hypothesis by comparing the frequency of left-handedness in migraine and tension headache patients at a headache center. Cluster headache cases were also included because Geschwind and Behan suspected that the association might be even stronger in this disorder. A special scoring method for handedness was devised by Geschwind and Behan to help identify a possible higher risk in mixed-handedness subjects. No significant associations emerged in any of these tests. A modest association of cluster headache and left-handedness disappeared when adjustment was made for the strong predilection of cluster headache for the male sex.

Adult↗
PubMed1986

Effects of enalapril and hydrochlorothiazide on blood pressure, renin-angiotensin system, and atrial natriuretic factor in essential hypertension: a double blind factorial cross-over study.

The hypotensive and hormonal effects of the angiotensin converting enzyme (ACE) inhibitor enalapril (10 mg twice daily) were compared with those of hydrochlorothiazide (25 mg twice daily), with the two drugs in combination and with placebo in 21 patients with essential hypertension. For each patient there were four randomised double-blind treatment phases, each of four weeks' duration, which comprised a 2 X 2 factorial experiment. All blood pressure parameters were reduced in the three active treatment phases compared to placebo (p less than 0.001). Supine mean blood pressures were 119 mmHg (placebo), 113 mmHg (hydrochlorothiazide), 108 mmHg (enalapril), and 98 mmHg (hydrochlorothiazide plus enalapril) (SEM 3 mmHg, ANOVA). Enalapril and hydrochlorothiazide were equally effective and well tolerated and their hypotensive effects were additive. Enalapril increased plasma renin activity (PRA), reduced plasma angiotensin II (AII) and aldosterone concentrations, and reduced ACE activity, whereas hydrochlorothiazide increased PRA, plasma AII, and aldosterone concentrations without altering ACE activity. With combination treatment the effects of enalapril on PRA and plasma AII concentrations were potentiated whereas those on plasma aldosterone concentration and ACE activity were additive. Atrial natriuretic factor plasma concentration in the placebo phase was 92 pg/ml and increased to 145 pg/ml in the hydrochlorothiazide phase (p less than 0.001, SEM 13 pg/ml), but there was no significant change in either the enalapril or combination phases.

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