Search PubMed⌕ Search

Biomedical subjects

J R Coppeto

Publications and source records attributed to J R Coppeto.

At least 37 records · Page 2Linked to original sources
PubMed1985

A microangiopathic syndrome of encephalopathy, hearing loss, and retinal arteriolar occlusions.

A syndrome consisting of a subacute encephalopathy, sensorineural hearing loss, and retinal arteriolar occlusions is described in two women. Laboratory investigations did not reveal any systemic vasculitis. CT and cerebral angiography showed no abnormalities, but magnetic resonance imaging revealed small, discrete lesions in the white matter. Biopsy of cortical brain from one patient showed disseminated microinfarcts in the gray matter as well as sclerosis of small vessels. This syndrome is characterized as an occlusive vasculopathy rather than vasculitis, and should be considered in evaluations of young women presenting with encephalopathy and hearing loss.

Adult↗
PubMed1985

Cryptic disseminated tuberculosis presenting as gaze palsy.

We present a case of gaze palsy caused by a pontine tuberculoma associated with cryptic disseminated tuberculosis. The only symptoms in this patient were those caused by her gaze abnormality despite the presence of disseminated tuberculosis that was later confirmed at autopsy.

Brain Diseases↗
PubMed1985

Chronic ophthalmic Wegener's granulomatosis.

A case of Wegener's granulomatosis is reported which manifested episcleritis followed by scleritis, and followed in turn by separate episodes of right and left orbital pseudotumor spanning 15 years prior to respiratory tract disease. The unusually protracted progression of symptoms in this case may be explained on the basis of the histopathological findings. Areas of fibrinoid necrosis of connective tissue occurred alone or alternated with areas of nongranulomatous fibrinoid necrosis of blood vessel walls. Granulomatours vasculitis was not observed. This histopathological picture is pathognomic of early cases of Wegener's granulomatosis which run especially protracted courses.

Biopsy↗
PubMed1985

Juxtapapillary subretinal hemorrhages in pseudotumor cerebri.

We report two cases of pseudotumor cerebri with subretinal hemorrhages. Bilateral juxtapapillary subretinal neovascular membranes were present in one. A unilateral hemorrhage occurred adjacent to a small anomalous optic disc in the other. Subretinal hemorrhages in papilledema may occur from juxtapapillary subretinal neovascular membranes that evolve rapidly and then involute. The relationship of the appearance and subsequent evolution of such juxtapapillary subretinal neovascular membranes to the course of the intracranial pressure is discussed. Occurrence in one eye may presage occurrence in the other eye, making control of intracranial pressure important once one eye is afflicted. Fortunately, severe permanent visual loss remains unreported. Some anomalous small optic discs may be particularly at risk for subretinal hemorrhage from papilledema because preexisting axonal crowding is aggravated by the swelling of the optic nerve from elevated intracranial pressure. Conditions related to the Valsalva maneuver that chronically or intermittently elevate intracranial pressure further and produce elevated cephalic venous pressure should be avoided.

Adult↗
PubMed1985

Transient ischemic attacks and amaurosis fugax from timolol.

A variety of neurological disturbances may occur in patients receiving ocular administration of timolol. Possible mechanisms include direct effects on neurons of the central nervous system, effects on peripheral vasculature, and cardiac arrhythmias. Interestingly, transient ischemic attacks have not been documented to occur synchronously with timolol-related arrhythmias. We report a case of recurrent dizziness and staggering gait occurring synchronously with timolol related arrhythmias. An attack of amaurosis fugax also occurred. Discontinuing timolol abolished all the symptoms. Pre-existing autonomic dysfunction in our patient may have been an important contributing factor in his symptomatology.

Aged↗
PubMed1985

Tonic pupils following oculomotor nerve palsies.

Four patients developed a unilateral tonic pupil following ipsilateral oculomotor nerve palsy. The probable basis for this phenomenon is misdirection of injured oculoparasympathetic fibers in the oculomotor nerve proximal to the ciliary ganglion.

Accommodation, Ocular↗
PubMed1984

A syndrome of arterial-occlusive retinopathy and encephalopathy.

An analysis of two new cases and four previously reported cases produced evidence for a syndrome of arterial-occlusive retinopathy and encephalopathy. All six patients were women; they ranged in age from 21 to 40 years. The clinical features of this condition include multiple branch retinal arterial occlusions and encephalopathy in which behavioral and memory disturbances predominate early. Hearing loss is frequent. Except for cerebrospinal fluid pleocytosis and an increased cerebrospinal fluid protein level, there are few laboratory or radiographic abnormalities. The disease may be responsive to corticosteroid therapy. There are some similarities between this syndrome and systemic lupus erythematosus but it appears to be a distinct disease entity. A comparison of the retinal findings with those described in experimental allergic encephalitis suggests that this may be a virally induced immune-mediated disease. Although only four clearly documented examples of this syndrome have been reported, we suspect that cases may have been overlooked because of failure to recognize arterial branch occlusions in the peripheral retina.

Adult↗
PubMed1984

Diffuse disseminated atheroembolism. Three cases with neuro-ophthalmic manifestation.

Neuro-ophthalmic manifestations led to the diagnosis of diffuse disseminated atheroembolism (DDA) in three men whose systemic symptoms had remained unexplained for years. The cholesterol emboli that cause DDA originate from friable plaques in the aorta and great vessels. Ophthalmologists should be alert to the diagnosis of DDA in patients with elevated ESRs, stroke, transient amaurosis, or cholesterol emboli in the fundi. Early diagnosis is important because arteriography, endarterectomy, and anticoagulation seem to increase the risk of serious, even fatal, embolization in these patients.

Aged↗
PubMed1984

Craniofacial dysmorphism and opsoclonus.

Report of a case with craniofacial dysmorphism and opsoclonus. The opsoclonus commenced in the perinatal period and abated at 18 months. Previous cases of opsoclonus associated with cranial and facial anomalies are reviewed, and it is suggested that opsoclonus in the authors' case was related to the delayed maturation of inhibitory cells in the brainstem.

Eye Diseases↗