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Biomedical subjects

J Puranen

Publications and source records attributed to J Puranen.

At least 55 records · Page 3Linked to original sources
PubMed1981

Lysosomal hydrolases in different compartments of rheumatoid and osteoarthrotic joints.

Tissue samples from 226 rheumatoid and osteoarthrotic joints displayed increased activities of three lysosomal enzymes compared with controls. Variations in activity were evident--one tissue cannot be blamed for all joint destruction, no one enzyme can be used as a diagnostic tool. Free enzyme activities in synovial fluid reflected those in tissues, especially in cartilage and bone. Increased values in osteoarthrotic sera, close correlation of ESR to activities in joint compartments, and higher values in synovial fluid, cartilage and bone of seronegative rheumatoid patients were recorded.

Adult↗
PubMed1981

Proteolytic enzymes in joint destruction.

An increase in both neutral and acid proteolytic activity and proteinase inhibitors is reported in synovial fluid of osteoarthrotic and rheumatoid joints, compared with controls, but in subchondral bone and articular cartilage only Cathepsin D and in synovial tissue only neutral caseinolysis were elevated. Especially high proteolytic activities were found in joint compartments of seronegative rheumatoid and in sera of osteoarthrotic patients. The source of the main part of neutral caseinolytic activity in joint fluid is inflammatory cells, in the case of Cathepsin D the tissues of origin seem to be bone and cartilage.

Arthritis, Rheumatoid↗
PubMed1981

Histopathological findings in joint diseases. Comparison with enzymatic changes and clinical laboratory data.

The histopathological diagNoses of 155 rheumatoid and osteoarthrotic patients, when made without knowing the clinical data, were in agreement with that made by clinicians in 70% of cases. No single histological feature was pathognomonic for either disease, though synovial tissue was most important for the diagnosis. Some correlations between histopathological changes, enzymatic status of joint compartments and the clinical laboratory data were found, but only in the case of mild synovitis. In the more severe synovitis cases, and in diseased cartilage and bone of rheumatoid and osteoarthrotic joints, the enzymatic changes were not systematically related with particular histopathological features. The histology reflects the past, while the enzymatic status anticipates the forthcoming events.

Arthritis, Rheumatoid↗
PubMed1981

Intracompartmental pressure increase on exertion in patients with chronic compartment syndrome in the leg.

Intracompartmental pressure in the leg was measured continuously during running in thirty-two patients who had either a medial or an anterior chronic compartment syndrome. It was found that on exertion the patients had significantly higher increases in pressure compared with the pressures in a control group. There were no remarkable differences between the two groups in terms of pressure at rest before exertion. After fasciotomy, the pressure returned to normal. The method that we employed to measure pressure can be use in diagnosing painful conditions of the leg.

Adolescent↗
PubMed1980

The venous drainage of the femoral neck as a prognostic sign in Perthes' disease.

The correlation between delayed venous drainage from the femoral neck and "head at risk" factors were studied in 47 patients (50 hips) with Perthes' disease. A good correlation was found between markedly disturbed venous drainage and "head at risk" factors. Lateral subluxation of the femoral head and Gage's sign correlated best with pathological venography. Thus a severely disturbed venous return from a hip with Perthes' disease seems to be a poor prognostic sign.

Child↗
PubMed1979

Athletes' leg pains.

The frequency and nature of exertion pains of the leg in athletes were studied in 2,750 cases of overuse injuries treated at the Sports Clinic of the Deaconess Institute of Oulu, Finland, during the years 1972-1977. 465 cases of exertion pain (18%) were located in the shin. The medial tibial syndrome was the most common overuse injury among these athletes, comprising 9.5% of all exertion injuries and 60% of the leg exertion pains. Together with stress fracture of the tibia, the second most common exertion pain of the leg, it accounted for 75% of the total leg pains. There are certain difficulties in differentiating between the medial tibial syndrome and stress fracture of the tibia. They both occur at the same site with similar symptoms. Radiological examination and isotope scanning are needed. The medial tibial syndrome is an overuse injury at the medial tibial border caused by running exercises. The pain is elicited by exertional ischaemia. The pathogenesis is explained by increased pressure in the fascial compartment of the deep flexor muscles due to prolonged exercise. Similar chronic ischaemic pains from exercise are also found in other fascial compartments of the leg, especially in the anterior compartment. The only treatment needed for stress fractures is rest from training. Fascial compartment pains also usually subside. If chronic fascial syndromes prevent training, fasciotomy is recommended as a reliable method to restore the athlete to normal training without pains.

Adolescent↗
PubMed1979

Venous drainage of the femoral neck in various stages of activity in Perthes' disease.

The venous drainage of the femoral neck in 73 children with Perthes' disease was analyzed from intraosseous venography films. 55 contralater symptomless hips were used as controls. In active stages of Perthes' disease, i.e. initial and fragmentation stage, the venous drainage was pathological in 46/55 hips (82%). In the restitution stage the finding was pathological in 7/18 (39%) and in healed Perthes' the venous drainage was normal in all six cases. Two out of the 55 symptomless hips showed pathological venous drainage. The disturbances in the venous drainage of the femoral neck seem to correlate with the stage of activity of Perthes' disease. Along with clinical and radiological signs of restitution the venous drainage seems to return to normal.

Adolescent↗
PubMed1978

Exertion injuries in adolescent athletes.

A series of 147 cases of exertion injuries in less than or equal to 15 years old athletes is presented. All injuries occurred during training or athletic performances without trauma and caused symptoms that prevented athletic exercises. There were 67 girls (46%) and 80 boys (54%) in the material. About 90% of them had been training for more than one year before the onset of the symptoms; 65% were interested in track and field athletics, 13% in ball games, 11% in skiing, 4% in swimming, and 3% in orienteering. The rest were interested in other sports. About 33% of the injuries were growth disturbances or osteochondroses seen also in other children. About 15% were anomalies, deformities or earlier osteochondritic changes, which caused first symptoms during the physical exercise; 50% were typical overuse injuries that may bother adult athletes, too; 43% of the injuries were localized in ankle, foot and heel, 31% in knee, 8% in back and trunk, 7% in pelvic and hip region, and the rest in other parts of the body. The injuries were generally slight, no permanent disability was noticed. Rest and conservation therapy cured most cases; operative treatment was used in only eight cases.

Adolescent↗
PubMed1978

Stress fractures caused by physical exercise.

A series of 142 stress fractures caused by sporting activities and physical exercise is presented. 121 fractures occurred in athletes and 21 in non-competitive sportsmen. Distance runners presented with 68 fractures, skiers 12, sprinters 10, orienteering runners 9, vaulters 3, and football-players 3 fractures. Athletes engaged in other events had fewer stress fractures. 76 fractures occurred in the tibia, 26 in the metatarsal bones, 20 in the fibula, 5 in the femoral neck, 4 in the femoral shaft, and 2 in the metacapal bones, lower pubic arch and sesamoid bones of the first MTP-joint. There was one fracture of each of the following: the humeral shaft, the ulna, the vertebral arch of L 5, the tarsal navicular and the proximal phalanx of the fifth toe. The treatment was generally a pause in training for 4-6 weeks, on the average. Running caused most of the stress fractures; the rest followed jumping exercises. The athletes mostly developed stress fractures during a period of alteration from one training session to another or during the preparation period close to the competition season. Joggers usually developped stress fractures 2-4 months after the beginning of regular training.

Adolescent↗
PubMed1978

Athlete exertion injuries.

Over a period of three years 829 cases of greater than or equal to 16-year-old athlete exertion injuries and syndromes were collected. There were 75 women and 754 men in the series. About 90% of the athletes had been training regularly for more than two years, and 75% of them trained 6 times a week or more. Approximately 52% of the injuries occurred in track and field athletics, about 17% in ball events, 13.6% in skiing, 7.4% in orienteering, and 4.7% in power events. Other sports were associated with fewer exertion injuries. 28.7% of the conditions occurred in the knee, 17% in the ankle, foot and heel, 14.8% in the leg, 8.2% in the back and trunk, 8.1% in the thigh, 7.4% in the achilles tendon. The rest were in the shoulder, neck and upper extremities. In 92% of the patients conservative treatment and rest were used. Only 8% of the cases were treated surgically.

Adolescent↗
PubMed1978

A new anti-inflammatory drug, proquazone, and ibuprofen in the treatment of degenerative joint disease of the knee (gonarthrosis). A double-blind comparative study.

The therapeutic effect and the tolerance of a new non-steriod anti-inflammatory compound, proquazone, were compared with those of ibuprofen in a double-blind, randomized study on patients with gonarthrosis. Totally 39 patients participated in the study: 19 patients in the proquazone group and 20 patients in the ibuprofen group. The two drugs were given in daily doses of 900 mg and 1200 mg respectively during 3 weeks. In both treatment groups a good result was achieved in more than 70% of the cases, but proquazone seemed to be more effective in reducing swelling and pain of knee. There were more side effects in the proquazone group than in the ibuprofen group, but they were generally mild and disappeared spontaneously. Only one patient in the proquazone group withdrew, because of epigastric discomfort.

Adult↗
PubMed1978

Coxal dysplasia in a pig. A case report.

A deformed hip joint which was accidentally found in a test pig is described. On the grounds of radiological, macroscopic and microscopic examinations, this is considered to be caused by a congenital dysplasia of the hip joint.

Animals↗
PubMed1977

Arthrography in the diagnosis of ligament injuries and classification of ankle injuries.

Arthrography was assessed in 300 cases of ankle injury to determine its diagnostic information yield and its aid in classifying ankle injuries. No complications occurred as a result of the procedure. In 59 cases, information gained from the procedure was verified at surgery. Arthrography was considered to give valuable information in 85% of the cases of ligament ruptures.

Ankle Injuries↗