Biomedical subjects

J Probst

Publications and source records attributed to J Probst.

At least 73 records · Page 4Linked to original sources

PubMed1976

[Chronic posttraumatic ostemyelitis. 3. Immunopathological aspects].

3. Immunological aspects 90 patients suffering from chronic posttraumatic osteomyelitis were examined immunologically. In 10-20% of the patients serum immunoglobulin levels were changed. Only 45% of the patients with staphylococcal infection had a positive anti-staphylolysin titer. In 10% of the patients so-called wound-specific antibodies were demonstrated; their possible autoimmune origin is discussed. A comparison of three groups of patients according to the immunological reactivity "hypoimmune", "humoral hyper-immune" and "cellular hyperimmune" showed that the worst clinical courses were observed in patinets with established delayed type hypersensitivity.

Antibodies, Bacterial↗

PubMed1976

[Chronic posttraumatic osteomyelitis. 2. Circulation problems].

Blood volume and total body water was determined in 20 patients suffering from chronic posttraumatic osteomyelitis and compared to the values from 15 healthy volunteers. Only patients who were unable to leave the bed, showed a marked decrease in circulating blood volume of more than 10%. Total body water remained essentially unchanged.

Adult↗

PubMed1976

[Chronic posttraumatic osteomyelitis. Clinical aspects and bacteriology].

50 patients suffering from chronic posttraumatic osteomyelitis were examined. In 66% an open fracture, caused either by traffic or industrial accidents was the primary reason for hospitalization. The most frequent pathogenic bacterium was staphylococcus aureus: 80% of the patients suffered from staphylococcal infections, mostly, however, in mixed culture with pseudomonas aeruginosa or clebsiella. Whereas the peripheral leukocyte count and the serum electrophoresis showed abnormal values only in a small percentage of the patients, the erythrocyte sedimentation rate proved to be a reliable index of the intensity of chronic infection.

Accidents, Occupational↗

PubMed1976

[Humoral and cell-mediated immune reactions in chronic posttraumatic osteomyelitis (author's transl)].

The humoral and cell mediated immune response was investigated in 90 patients suffering from chronic posttraumatic osteomyelitis. In 10-20% of the patients the serum IgG and IgM was increased, in 5-10% the levels were decreased. The values were compared with those of a control group of 35 normal healthy volunteers. Of 55 patients with staphylococcal infection only 25 had a positive antistaphylolysin titer. Eleven out of 25 patients with staphylococcal osteomyelitis showed a positive in vitro lymphocyte transformation after stimulation with alpha-staphylolysin (mean transformation rate 5.4 equal to or less than 0.9). The phytohemagglutinin and the pokeweed-mitogen response were normal. A comparison of the immunological reactivity of the patients and the clinical severity of the disease showed that patients with established delayed-type hypersensitivity phenomena suffered a significantly worse clinical course of the disease.

Antibody Formation↗

PubMed1975