Biomedical subjects
J Pinkhas
Publications and source records attributed to J Pinkhas.
Salazopyrine-induced tachycardia.
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Circulating anticoagulant and serological tests for syphilis.
Circulating anticoagulant (CA) and particularly lupus anticoagulant are commonly associated with biological false-positive tests for syphilis (BFP-STS) in patients with collagen diseases. CA was presently found in the sera of 8 out of 30 subjects with chronic BFP-STS without collagen or autoimmune diseases. It was not found in any of the 21 patients with various stages of syphilis. In 5 out of 21 elderly subjects (age greater than 70 years) in whom a positive BFP-STS was detected, there was no CA. It is concluded that the association between CA and BFP-STS is found only in patients with collagen and autoimmune diseases and in some of the younger chronic BFP-STS reactors. It is not detected in syphilitic patients or elderly subjects in whom a high incidence of BFP-STS can be found. The difference in the incidence of this association is probably due to the differing biologic behaviour of these autoantibodies.
Activity of adenosine deaminase and of purine nucleoside phosphorylase in peripheral lymphocytes from patients with acquired immunological disorders.
The activity of adenosine deaminase (ADA) and of purine nucleoside phosphorylase (PNP) was determined in the peripheral lymphocytes of patients with diseases associated with acquired partial dysfunction of the immune response. Increase ADA activity was found in patients with Waldenstrom's macroglobulinemia and in some patients with non-Hodgkin's lymphoma. Increased PNP activity was found in patients with non Hodgkin's lymphoma whereas decreased PNP activity was fund in patients with connective tissue disorders. The alternations found in ADA and PNP activities probably reflect changes in the lymphocyte subpopulations and do not seem to have an etiological role in the pathogenesis of the disturbed immune response.
Hypercalcemia in Hodgkin's disease.
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Oculomotor nerve paresis-presenting sign of acute myeloblastic leukemia in a patient with polycythemia vera.
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Hemochromatosis in a renal transplant recipient.
A 47 year old kidney transplant recipient who died from liver failure caused by hemochromatosis, is described. The diagnosis was established by post mortem examination. The question whether these findings are an extreme form of the common pathological changes seen in the liver in other transplant recipients, or were related to infectious hepatitis or were due to the use of immunosuppressive therapy, remains unanswered.
Erythrocytosis following renal transplantation.
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[Articular involvement in leukemia].
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Cryoglobulinemia in chronic liver diseases.
Cryoglobulins were detected in six patients with chronic liver diseases. Three of them had postnecrotic cirrhosis, two had chronic active hepatitis and one had primary biliary cirrhosis. In none of them HBsAG or its antibody were detected. The cryoglobulin appeared during the course of the disease in two patients, one with chronic active hepatitis and the other with primary biliary cirrhosis. There was no proof for cause and effect relationship between the liver disease with cryoglobulinemia and an eventual infection with hepatitis b virus. The cryoglobulinemia might be due to the liver disease per se and it seems that it is not always related to an infection caused by the hepatitis B virus.
Diffuse melanosis secondary to disseminated malignant melanoma.
A patient with melanosis and melanuria in whom disseminated malignant melanoma was found is described herein. The primary malignant process was not detected in the skin. Light and electron microscopic examinations, as well as cytochemical studies, revealed numerous melanin-containing macrophages in the skin.
Viral hepatitis with extreme hyperbilirubinemia, massive hemolysis and encephalopathy in a patient with a new G6PD variant.
Extreme hyperbilirubinemia, massive hemolysis and hepatic encephalopathy were reported in a G6PD-deficient patient with viral hepatitis. Investigation of the G6PD properties revealed that this patient's enzyme represented a hitherto undescribed variant (Bnei Brak), characterized by heat stability and a unique triphasic pH-related enzyme activity curve. It is possible that the marked hemolytic process in this patient was enhanced by a further decrease in the activity of the already deficient enzyme during acidosis.
Transient mixed cryoglobulinemia associated with typhoid hepatitis.
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[Diagnostic problems of primary liver cancer in the cirrhotic patient].
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Ejaculatio praecox and spurious polycythemia.
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[Erythrocytosis following renal transplantation].
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