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Biomedical subjects

J Parnas

Publications and source records attributed to J Parnas.

At least 73 records · Page 4Linked to original sources
PubMed1979

Sodium valproate, serum level and clinical effect in epilepsy: a controlled study.

Clinical effects at three different serum levels of sodium valproate (VPA) were compared in a triple-blind, multiple crossover trial comprising 13 epileptic inpatients. Patients were selected regardless of seizure type, and all were in concomitant antiepileptic treatment, which was kept constant throughout the study. A significant relationship between the decrease in number of seizures and increasing VPA serum level was demonstrated. The relationship between VPA dose and serum level was curvilinear. Statistical evaluation of patients by seizure type in relation to clinical effect of VPA was only possible for secondary generalized seizures. Between phenytoin, phenobarbital, and carbamazepine and the different VPA serum levels no interactions could be demonstrated. Recorded side effects were always mild and transient. No obvious correlation between side effects and VPA serum level was established.

Adolescent↗
PubMed1979

Psychotropic effect of antiepileptic drugs.

Eighteen controlled studies investigating the psychotropic effect of anti-epileptic drugs are critically reviewed. The neurochemical evidence for existence of psychotropic properties is still speculative. It seems questionable on the basis of this survey that there exist genuine psychotropic effects of antiepileptic drugs, which are not related to antiepileptic efficacy and/or differences in toxicity.

Anticonvulsants↗
PubMed1979

A clinical study of 44 patients with juvenile amaurotic family idiocy.

The material presented comprises 44 patients with juvenile amaurotic family idiocy. The disease is distinguished from other types of gangliosidoses, and earlier clinical descriptions are reviewed. The median age of the patients at the onset of the diseases was 5.8 years and median duration of life was 18.8 years. It appears probable that the disease takes two different courses. Besides the earlier described accompanying phenomena, dystonic attack with oculogyre crises have been found in some patients, as well as extreme cases of bradycardia. In 77% of the patients psychotic manifestations have been found, chiefly in the form of frightening visual hallucinations. The pathogenesis and clinical observations of the psychoses are discussed and environmental factors are pointed out as contributing to the pathogenesis of the psychoses.

Adolescent↗
PubMed1978

Excretion of antiepileptic drugs in sweat.

In eight epileptic patients receiving chronic antiepileptic treatment, a study of the excretion in sweat of phenytoin, phenobarbitone and carbamazepine was performed. All three drugs were found to be present in sweat. Phenytoin sweat concentration was found to correspond to the free fraction in plasma and to be independent of sweat flow. Phenobarbitone sweat concentration was found to increase with increasing sweat flow. Regarding drug level monitoring it is proposed that under changing climatic conditions the phenomenon may be of clinical significance.

Adolescent↗
PubMed1978

[Not Available].

Explore the source record for details and available documents.

Congresses as Topic↗
PubMed1977

"R"-living vaccine against colibacillosis. Communication I.

After our estimation of the LD100 of enteropathogenic E. coli 0149 and 0138 (and their toxins) in rabbits and mice (intravenously and subcutaneously or intraperitoneally, respectively), rabbits and mice were vaccinated subcutaneously by the living "R" 0149 vaccine. All animals showed resistance against the LD100 of both E. coli serotypes; this state of resistance lasted 1-5 months in rabbits, and 1-3 months in mice. Sera of vaccinated rabbits showed bactericidal activity against both E. coli serotypes. The R-E-system of rabbits which were immunized by the endotoxin of "R" 0149 living vaccine, showed mobilization of immunocytes. The vaccine seems to be harmless to newborn piglets after oral vaccination; 2 colostrum deprived piglets, despite vaccination at once after birth, did not survive the big chalenge with 100 ml of broth culture of E. coli 0149 "S" (anapylactic shock). But in comparison to 1 not vaccinated control piglet, the two piglests showed only few E. coli colonies in the intestines, while the intestine of the control animal was very massively colonized by the virulent strain. As the immunizing potency of the "R" 0149 living vaccine was clearly shown in rabbits and mice, further investigations on piglets (newborns, weaning epriod, and after weaning) are needed, to state whether the value of this vaccine corresponds with the immunizing potency shown in our preliminary experiments. The "R"-vaccine seems to open some perspective in colibacillosis prevention of children and animals, and therefore it deserves our attention.

Animals↗
PubMed1977

Leptospirae: their place in the systematics.

The morphology and electron-microscopic anatomy of Leptospirae, the lack of the presence of leptospiral phages (and probably of bacteriocins), and the absence of phagocytosis as a defence mechanism in leptospirosis, indicate the non-bacteriologie character of this genus. Leptospirae form an evolutionary intermediate bridge between the worlds of bacteria and protozoa. In "Bergey's Manual" they are assigned to the world of bacteria for practical reasons; but it seems to be reasonable to stress more largely the "bacteriological" and "protozoologic" markers of Leptospirae, in the subsequent 9th edition of this Manual.

Bacteria↗
PubMed1976

[The genus Brucella, its nomenclature and taxonomic specificity (author's transl)].

The author suggest to change the nomenclature of Genus-Brucella as follows: Brucella melitensis, B. bovis, B. suis, B. canis, B. neotomae, B. rangiferi, B. murium. In the new edition of "Bergey's Manual" it is suggested to quote some highly taxonomic specific substances, berucellaphages, Brucelline, protective substance, precipitinogen, and toxins (Endotoxin, Lipoprotein).

Antigens, Bacterial↗
PubMed1976

[About the influence of beta-toxin of Clostridium perfringens (type C) on the motorics of intestine segments (in vitro). I. Communication].

The Beta-Toxin of Clostridium perfringens (Type C) was introduced intra lumen to jejunum and ileum segments of rabbits, then examined by pharmacologic method (in vitro). The Beta-Toxin showed a paralysing activity on the motorics of the intestine which fact may be in relation to the paralysing activity of this toxin in dysenteria in piglets.

Animals↗
PubMed1975

[The endotoxin from S-, R- and M-forms of enteropathogenic E. coli O 149: pyrogenicity, Shwartzman-phenomenon and hypersensitivity (author's transl)].

The authors are interested in elucidation of the role of endotoxin from S, R- and M-forms of E. coli O 149, and of the role of hypersensitivity in pathogenesis of Colibacillosis. It was shown in this experiment that all S, R- and M-form of E. coli O149 possess endotoxin with almost the same pyrogenicity in normal rabbits. The pyrogenicity increases enormously in the hypersensitized rabbit. There were also not observed differences between endotoxins extracted from S, R, M-mutnants. All 3 endotoxins evoke in normal rabbits the skin Shwartzman-Phenomenon, the S-endotoxin was there much stronger. This phenomenon increases in capacity in hypersensitized rabbits. Thus again, the role of hypersensitivity in Colibacillosis was proved to be important.

Animals↗
PubMed1975

[Mucous (M) mutants of enteropathogenic, septicemic and saprophytic E. coli (author's transl)].

Mucoid M mutants of enteropathogenic (for suckling pigs), septicemic (for calves), and saprophytic E. Coli were subject of the study. The characteristics of the M colonies have been listed in Table 1. Both spontaneously occurring M mutants which had been isolated by culturing of E. coli strains (S form) in normal horse serum (undiluted) for several weeks were observed. Enzymatic-biochemical tests revealed the existence of M mutants with full enzmatic activity which are identical with the homologous S and R forms. There were also M mutants exhibiting a considerably reduced enzymatic activity. Antigenic-serological analysis (agglutination) exhibited M mutants which were agglutinated by the homologous sera, at low and high titres. In contrast to this, one group of M mutants was found not to be agglutinable, despite autoclaving at 120 degrees C for 2 hours. Some mutants cultured in broth for several weeks were re-exhibiting S colonies of full biochemical activity and full antigen reactivity against homologous agglutinating sera.

Agglutination Tests↗