Search PubMed⌕ Search

Biomedical subjects

J Oosting

Publications and source records attributed to J Oosting.

At least 91 records · Page 5Linked to original sources
PubMed1989

Predictors of foetal and neonatal mortality in Curaçao, Netherlands Antilles. A multivariate analysis.

In Curaçao a systematic and comprehensive investigation of numerous factors, potentially associated with an increased risk of foetal and neonatal mortality, was carried out in a 2-year period (1984-85). The inquiry was restricted to singleton births. Data on 205 women who experienced pregnancy loss were compared with those on 913 women who did not sustain foetal or neonatal loss. Data comprised information on maternal characteristics, clinical course of pregnancy and delivery, and neonatal characteristics. Of 130 factors measured, 14 were entered into a multivariate analysis. From the analysis 5 risk factors emerged as significant predictors of mortality: gestational age, birth weight, sex, foetal presentation and congenital anomalies. Factors such as social class, marital status, maternal age and parity were not associated with an increased risk of foetal and neonatal mortality in Curaçao.

Adult↗
PubMed1989

The effects of bupivacaine and pipecoloxylidide on platelet function in vitro.

The influence of bupivacaine and its major metabolite, pipecoloxylidide, on human platelet function was studied in vitro. Significant inhibition of ADP and collagen-induced platelet aggregation occurred only with concentrations of bupivacaine above 10 micrograms.ml-1. This concentration (10-25 micrograms.ml-1) is much higher than would be expected in routine clinical use of bupivacaine for epidural analgesia. The inhibition of platelet aggregation was associated with a significant decrease in beta-thromboglobulin secretion. In contrast, pipecoloxylidide had no effect on platelet aggregation or the beta-thromboglobulin release. We conclude that the previously reported 30-min time-lag between the maximal plasma concentration of bupivacaine and the inhibition of platelet aggregation is unlikely to be due to a metabolism of bupivacaine to pipecoloxylidide.

Adult↗
PubMed1989

Resectional surgical procedures for carcinoma of the head of the pancreas.

Of a total series of 103 patients with preoperatively diagnosed carcinoma of the head of the pancreas (including ampullary carcinoma, carcinoma of the distal part of the common bile duct and pancreatic duct and acinar cell carcinoma), 78 underwent pancreatic resection. The remaining 25 had palliative surgical treatment, either a gastric or biliary bypass, and are not included in the present study. Three of the 78 patients who underwent pancreatic resection died, and ten patients required early reoperation. Predictive criteria could be formulated for the prognosis and outcome of the patients with carcinoma of the head of the pancreas. The most reliable index for survival time of the patients proved to be the radicality of the resection, which was directly related to the differentiation of the primary tumor. Forty-three of 48 patients who underwent radical resection are alive, with a survival time ranging from three to 49 months. Eleven of 23 patients who underwent palliative resection are alive, with a survival time ranging from two to 29 months. Of 44 patients with well or moderately differentiated adenocarcinoma who underwent radical resection, 38 are alive, with a survival time ranging from six to 41 months (mean of 29 months).

Adenocarcinoma↗
PubMed1988

On the cause of the retardation of fetal growth in multiple gestations.

The birthweights and placental weights of 3000 singletons, 1500 twin pairs and 67 triplets are studied in relation to the gestational age. From 30-32 weeks onwards, newborns of twin- and triplet gestation show lower birthweight as compared to singleton newborns. Placental indices (placental weights related to birthweights) are about alike in singletons, twins and triplets. From about 24 weeks onwards placental weights of twin and triplet newborns are smaller as compared to those of singletons. Obviously, children in multiple gestations become growth retarded, preceded by and very likely due to poor early placental development (placental crowding of the uterus).

Birth Weight↗
PubMed1988

Maternal whole blood viscosity in pregnancy hypertension.

Hemoconcentration is prominent in preeclampsia. Concomitant changes in the flow properties of maternal blood, i.e. in whole blood viscosity (WBV), might be related to the occurrence of fetal or maternal complications. To test this hypothesis, WBV was estimated in 228 pregnancies. Patients were assigned to one of four groups according to maximum diastolic blood pressure. Significantly higher WBV values were found in the more hypertensive groups throughout pregnancy. WBV data, obtained between 26 and 36 weeks of amenorrhea, contributed significantly, independently of hypertension, to the prediction of fetal outcome. With regard to maternal complications, no significant contribution of WBV data could be established independently of blood pressure. The results support the hypothesis that WBV is a determining factor in the efficacy of placental perfusion.

Blood Viscosity↗
PubMed1988

Longitudinal changes in blood viscosity are correlated with fetal outcome.

The importance of longitudinal changes in maternal Whole Blood Viscosity (WBV) for fetal well-being was investigated. Consecutive WBV data were available, obtained from 44 pregnancies before 36 0/7 weeks. An increase in WBV was found to be associated with an unfavorable fetal outcome. This result might be considered as clinical evidence supporting the hypothesis that maternal WBV contains information on the efficacy of placental perfusion.

Adult↗
PubMed1988

Application of methods used in survival analysis to growth and nutritional studies.

Three statistical methods are described and illustrated with working examples. Using these methods it is possible to include all subjects involved in cross-sectional studies in calculations of results, even if the data are incomplete at the end of the investigation. The use of censored data is taken from survival analysis. It is shown that combination of the Kaplan-Meier estimate, the log-rank test and the proportional hazards model gives more satisfactory results in nutritional and growth studies.

Breast Feeding↗
PubMed1987

The influence of maternal whole blood viscosity on fetal growth.

To explore the relevance of the rheological properties of maternal blood in pregnancy to fetal growth a study of whole blood viscosity (WBV) was conducted in the early third trimester of 138 pregnancies. A significant negative correlation was found between WBV at low shear rate and birthweight centile. As the rheological parameters were found to be negatively correlated with the placenta coefficient, an independent role for maternal WBV seems likely. When WBV, placental weight and degree of infarction accounted for significant contributions in a logistic regression model, diastolic blood pressure data did not assist in the correct prediction of occurrence of a low birthweight centile (less than 10th). A simplified model is proposed, to explain the mechanisms by which some clinical variables may express their influence on fetal growth. In conclusion, it is suggested that WBV might be considered one of the factors which determine the efficacy of placental perfusion on the maternal side. However, as this variation in efficacy of placental perfusion is only weakly reflected in variations in birthweight, the influence of WBV on fetal growth cannot be very important.

Adolescent↗
PubMed1987

Clinical and EEG prediction of seizure recurrence following antiepileptic drug withdrawal.

A prospective study is reported of antiepileptic drug withdrawal in 62 neurologically intact adult patients who had become seizure-free at least 3 years previously. No single clinical or laboratory finding was reliably predictive of outcome and in particular the presence of epileptiform EEG activity prior to AED withdrawal or appearance of such activity during withdrawal was not associated with relapse. A multivariate model was however developed which suggested that patients capable of remaining seizure-free without medication could be reliably identified at a much reduced cost of relapses in the remainder.

Adolescent↗
PubMed1987

Bell's palsy: factors affecting the prognosis in 200 patients with reference to hypertension and diabetes mellitus.

In an effort to refine and amplify the basis for clinical prognosis in Bell's palsy, 14 factors in a clinical study were analysed. From the results, it is still impossible to make a certain prognosis of recovery in the individual patient. However, it is obvious that, based on degree of paresis on assessment, and to a lesser degree the MAP value, at least a quantitative statement can be made.

Diabetic Neuropathies↗
PubMed1986

Influence of extradural blockade and ephedrine on transcutaneous oxygen tension.

The influence of lumbar extradural blockade with 0.5% pain bupivacaine on transcutaneous oxygen tension (PtcO2) and skin temperature was studied in 20 patients, 10 scheduled for vascular surgery and 10 for urological surgery. At the time of maximum extent of blockade, mean arterial pressure (MAP) had decreased significantly (P less than 0.001) from 96.6 +/- 18.8 mm Hg to 69.5 +/- 10.1 (mean +/- SD) in the vascular group and from 88.0 +/- 14.7 mm Hg to 71.1 +/- 12 mm Hg in the urological group. In the vascular group PtcO2 decreased significantly in the ischaemic (P less than 0.01) and non-ischaemic (P less than 0.001) limbs. In the urological group, there was a significant (P less than 0.001) decrease in PtcO2 in both limbs. There was no change in cutaneous temperature in the ischaemic limbs (vascular group), but the temperature in the non-ischaemic limbs increased significantly (P less than 0.01). In the urological group, the cutaneous temperature increased significantly (P less than 0.001) in both limbs. When ephedrine 10 mg was administered i.v., MAP increased significantly (P less than 0.001) in both groups to pre-blockade values. This was accompanied in both groups by significant increases in PtcO2' but not by a change in skin temperature. There was a significant correlation between change in MAP and change in PtcO2 in both groups after ephedrine.

Aged↗
PubMed1984

Methods for comparing groups of growth curves when patterns of observation times vary among subjects.

A variety of statistical techniques is available if growth is to be compared for two groups followed up over a certain period. In practice straightforward application of such techniques may be hampered if patterns of observation times vary among subjects. Different approaches to deal with such variation are illustrated by analysing data from infants (0-18 months) living in Lesotho, Southern Africa. Data comprises 236 individual series of multiple measurements on five anthropometric variables. Individual patterns of observation times differ because of variation in a) age at entry, b) length of follow-up, and c) observation intervals (nominally 4 weeks). First an ad hoc approach is followed by taking a few summary measures for each individual series, e.g. 'growth velocity'. By contrast two other approaches hinge on preliminary data transformation required to make standard techniques applicable. The pros and cons of the different approaches are discussed.

Anthropometry↗
PubMed1984

Correlations between measurements in preschool children living on a former island.

At the ages of 0.5 and 5 years correlation coefficients between measurements of the head and the whole body of children living on the former island of Marken have been calculated. The correlation coefficients between the size of the body and the size of the head are about 0.5; the correlation coefficients between the different dimensions of the head are low. The sex-differences at the age of 0.5 years suggest that the growth pattern of girls is less fixed than that of boys during the first years after birth. It is discussed whether this could be ascribed to the well known better adaptation of growth in girls than in boys or to the absence of harmful environmental conditions. No effect of inbreeding or endogamy could be demonstrated.

Age Factors↗