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Biomedical subjects

J Okada

Publications and source records attributed to J Okada.

At least 253 records · Page 14Linked to original sources
PubMed1975

[Changes of antimicrobial susceptibility of anaerobic bacteria from clinical specimens (author's transl)].

The susceptibility to several commonly used antimicrobial agents was examined on approximately 900 isolates of various anaerobes from clinical specimens between October 1965 to May 1975, and the changes of susceptibility were investigated. Antimicrobial agents tested were penicillin G (PC-G), ampicillin (AB-PC), cephaloridine (CER), erythromycin (EM), josamycin (JM), lincomycin (LCM), clindamycin (CLDM), chloramphenicol (CP) and tetracycline (TC). And thiamphenicol (TP) and doxycycline (DOTC) were also used against recently isolated organisms. Minimal inhibitory concentrations (MIC) were determined with agar plate dilution method. The activity of PC-G, AB-PC and CER against almost all strains of anaerobes was good at 12.5 mug/ml or less, but a marked increase of resistant strains of Bacteroides was recognized. EM, JM and LCM had similar activity against anaerobes, and were effective to most strains of anaerobes except for Veillonella, Bacteroides and Fusobacterium. CLDM was highly active against almost all strains of anaerobes, and more active than the two macrolides and LCM. But recently, significant increase in resistant strains was observed among Bacteroides. CP had good activity against all strains of anaerobes, and the increase of resistant strains was not recognized. TP had a similar good activity as CP. While, activity of TC against all anaerobes was poor at the level of 25 mug/ml or more. DOTC was more active than TC against all strains tested.

Ampicillin↗
PubMed1975

Studies on the intrathecal pharmacotherapy. Part I: CDP-choline.

A study was made of the intrathecal infusion as a route of administration of drugs for the CNS, by giving due consideration to the presence of blood-brain and CSF-brain barriers. CDP-choline was used as the brain activator, and the effect of the drug intrathecally infused was investigated both clinically and by experiments on animals. Seven patients with a disturbance of consciousness due to primary brain lesion received a total of 19 intrathecal infusions of CDP-choline, and were examined for the effect of the treatment neurologically and electroencephalographically. Wistar rats were infused either intravascularly or intracisternally with 14C-CDP-choline, and the distribution in the body was investigated by whole body autoradiography.

Adolescent↗