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Biomedical subjects

J Okada

Publications and source records attributed to J Okada.

At least 235 records · Page 13Linked to original sources
PubMed1977

Dural haemangioma with extracranial component.

A rare case of dural haemangioma with extracranial component is described. A subcutaneous frontal tumour was thought before operation to have originated in the skull. Angiography showed drainage into the superior sagittal sinus via a cortical vein. Dural haemangioma is thought to be a clinical rarity. Also, an arteriovenous malformation draining into the superior sagittal sinus is rarely encountered.

Adult↗
PubMed1977

Interpretation of dissolution rate data from in vitro testing of compressed tablets.

To find if theoretically and experimentally a relation existed between the dissolution rate theory of Kitazawa, Johno & others (1975) and that of Wagner (1969), a study was undertaken with uncoated caffeine, aspirin and proxyphylline tablets using two dissolution methods. Although the original treatment for surface area of drug available for dissolution was quite different between the two dissolution theories, the dissolution rate constants obtained were in fair agreement. Hence it might not be always necessary to take into consideration changes in the surface area as a function of dissolution rate, and the 1n W infinity/(W infinity) versus time plot devised by Kitazawa & others might be a useful and simple means of obtaining the dissolution rate constant of an active ingredient from a dosage form such as compressed tablet.

Aspirin↗
PubMed1977

A comparison of the dissolution rates of caffeine tablets in a rotating-basket with those in a Sartorius dissolution tester.

Uncoated caffeine tablets of four different hardnesses were tested for dissolution rate by the Sartorius (S.S. method) and by the rotating basket method of the U.S.P. XVIII. In both methods the dissolution rate decreased with increasing hardness, and the rate obtained with the S.S. method was always less than that by the U.S.P. method. This result cannot be explained as being due only to the difference in the volume of dissolution medium. Also it was difficult to ensure that the characteristic changes in the process of dissolution paralleled the curves obtained from a plot of % caffeine dissolved vs time. Accordingly, the dissolution rate constants were calculated from the slope of each straight line in a plot of ln W infinity/(W infinity --W) vs time.

Caffeine↗
PubMed1977

[The combination effect of ampicillin and dicloxacillin on the strains of Bacteriodes fragilis isolated from clinical specimens (author's transl)].

The antimicrobial activities of ampicillin (ABPC) and dicloxacillin (MDIPC) alone were tested in 100 strains of B. fragilis isolated from clinical specimens, and combined activity of ABPC and MDIPC was investigated employing a chequer board titration method (Box method) with agar plates and liquid media. The following results were obtained. 1. Of the 100 strains tested, approximately 33% were shown to have MICs of ABPC greater than 100 mcg/ml, whereas 92% of strains were greater than 100 mcg/ml to MDIPC. 2. In the combination, antimicrobial activities were demonstrated additive or synergistic action in almost strains tested. 3. A combined effect of these drugs was proved by agar dilution method for the strains, for which the same effect was shown by the tube dilution method. 4. For ABPC-resistant strains, no increase in antibacterial activity of these drugs by combination was demonstrated.

Ampicillin↗