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Biomedical subjects

J Okada

Publications and source records attributed to J Okada.

At least 181 records · Page 10Linked to original sources
PubMed1985

Inclusion compounds of lankacidin-group antibiotics with cyclodextrins.

Lankacidin-group antibiotics formed inclusion compounds with beta-cyclodextrin in molar ratios of about 1:1. These compounds showed remarkably improved water-solubility and stability in aqueous solutions. The structure of the inclusion compounds of lankacidin A is proposed based on the facility of their inclusion with beta-cyclodextrin and the results of 1H NMR spectral studies.

Anti-Bacterial Agents↗
PubMed1985

Red cell deformability in patients with cerebral vasospasm.

Red cell deformability was compared between two groups with and without severe cerebral vasospasm. The results obtained revealed that deformability was decreased in the former as compared to the latter. Pentoxifylline, an ameliorant of microcirculation, also demonstrated the tendency to improve deformability in the case of vasospasm. But improving efficacy for clinical manifestations could not be met only by virtue of such a change while favorable.

Adult↗
PubMed1985

Subcellular localization of acid lipase in rat liver.

The intracellular localization of acid lipase was examined by several subcellular fractionation techniques. Upon differential centrifugation, acid lipase was detected mainly in the lysosomal fraction. When linear sucrose density gradient centrifugation was used, the mean density of acid lipase was similar to that of lysosomal marker enzymes. After Triton-treatment of rats, however, acid lipase was recovered at a density of 1.10-1.16, which is more than that of tritosomes, when tissues were homogenized with a Potter-Elvehjem homogenizer. But by homogenizing the liver from these rats by pressing it through a stainless steel net, acid lipase was mainly recovered at the same density as that of tritosomes. These results indicate that acid lipase is localized mainly in lysosomes in rat liver.

Animals↗
PubMed1983

Transmitter sensitivities in oval neurons from rat brainstem cultures.

Using cultures of dissociated neurons from the lower brainstem of 14-15-day-old rat embryos, we studied a specific relation between neuronal activities of small-sized oval neurons and their sensitivities to various transmitter substances. Oval neurons were characterized by non-effective responses to acetylcholine and a facilitatory response to both leucine- and methionine-enkephalin.

Animals↗