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J N Cox

Publications and source records attributed to J N Cox.

At least 37 records · Page 2Linked to original sources
PubMed1988

Collagenous colitis: histologic, morphometric, immunohistochemical and ultrastructural studies. Report of 21 cases.

We examined 129 colonic biopsies from 21 patients with collagenous colitis, most of whom presented with diarrhoea. Morphometric measurements gave a mean thickness of the subepithelial collagen deposit of 19.5 mu +/- 5.1. The trapped fusiform and/or stellate cells within the deposits were identified immunohistochemically as myoid cells, being positive with antibody against smooth muscle cell alpha-actin. Ultrastructurally, these cells have all the characteristic features of myofibroblasts. Similar cells are also present along the crypts, where they were formerly referred to as pericryptal fibroblasts. Although there is still much debate as to the pathogenesis of this condition, we would like to suggest that collagenous colitis is a disease of pericryptal myofibroblasts. During their migration and maturation into the subepithelial region they may synthesize an excess of collagen, under some yet unknown or undefined stimulus/stimuli.

Adult↗
PubMed1988

VATER association: report of a case with three unreported malformations.

The VATER association is the sporadic non-random association of Vertebral anomalies, Anal atresia, Tracheo-oesophageal fistula with Esophageal atresia, Renal defects, and Radial limb dysplasia. Cardiac defects are common, as are other limb malformations. The present report describes a premature infant with most of the known major and minor defects of the association as well as agenesis of the bladder and penis and an askeletal rudimentary tail. The latter have not previously been described.

Abnormalities, Multiple↗
PubMed1988

Muscle in hallux valgus.

Muscle imbalance is cited widely as a major factor in the production of hallux valgus deformity. The authors, therefore, performed muscle biopsies in 57 patients (53 women and four men; average age, 45.3 years) to examine the histology and ultrastructure of the intrinsic muscles about the great toe. The biopsy study was correlated with gait analysis. In 53 biopsy specimens the muscles were found to be histologically abnormal, presenting myogenic and neurogenic alterations. Furthermore, ultrastructural examination showed enlarged mitochondria with paracrystalline inclusions in 31 of the 57 cases. Gait analysis showed an abnormal rollover pattern in 70% of the gait cycles examined in 19 symptomatic hallux valgus patients (18 women and one man), while in 19 asymptomatic volunteers (16 women and three men) 80% of the cycles examined were normal. The surface electromyographic (EMG) activity of the intrinsic muscles also was abnormal in the patient group when compared with the volunteer group; five different patterns of electrical activity were found. These findings may be interpreted as a result of chronic ischemia caused by the elevated pressure occurring within the foot during gait.

Adolescent↗
PubMed1987

Ultrastructural modifications of muscle in three types of compartment syndrome.

The histological and ultrastructural aspects of three cases representing different types of compartment syndromes are analyzed. In the acute syndrome edema is the prominent feature. The two chronic cases are characterized by an accumulation of intermyofibrillar lipid globules. All three have in common mitochondrial enlargement, disorganization of the cristae and paracrystalline inclusions. These pathological findings are discussed in the light of lesions seen in striated muscle ischaemia or in certain metabolic myopathies.

Acute Disease↗
PubMed1986

[Full-contact and dissecting aneurysm of the thrombosed left internal carotid artery associated with encephalomalacia].

Full-contact, a sport which is becoming more and more popular in our society as a means of self-defence, is not without its hazards. We describe the case of a 32-year-old man who, shortly after an intensive practice match, presented symptoms consistent with cerebral damage which resulted in his death within three days. The main pathological findings were confined to the left internal carotid artery, which presented a dissecting aneurysm as a result of rupture of its intima with thrombosis of its lumen. The thrombus extended as far as the intracranial portion of the artery, resulting in massive cerebral infarction as cause of death. Furthermore, there were histological modifications of both main carotid arteries and their branches which suggested repeated microtraumatic events. The causal relation between the lesions observed and the practice of full-contact are discussed.

Adult↗
PubMed1986

Lethal multiple pterygium syndrome: report of a new case with hydranencephaly.

A 28-week male fetus with the cardinal signs of the lethal multiple pterygium syndrome (multiple pterygia, congenital joint contractures, lung hypoplasia, facial abnormalities, and hydrops) is reported here. In addition, he had hydranencephaly, an anomaly not yet reported in this group of conditions. This potentially new form of the lethal multiple pterygium was detected prenatally by ultrasound examination. In discussing the case, we consider the probable autosomal recessive inheritance pattern and raise questions about the etiology and heterogeneity of this syndrome.

Anencephaly↗
PubMed1986

Chronic Q fever endocarditis with massive splenomegaly in childhood.

Two children with congenital heart disease developed persistent fever, anemia, and hepatosplenomegaly. Both were shown to have intracardiac vegetations and evidence of infection with Coxiella burnetti. Thus, the same clinical manifestations of Q fever may develop in both children and adults.

Adolescent↗
PubMed1985

[Nonspecific granulomatous prostatitis. Histopathological study of 53 cases with a review of the literature].

Over a 12-year period (1971-1983), 6868 prostatic biopsies were received and examined at the Department of Pathology, Geneva. 53 (0.77%) presented with non-caseous granulomatous prostatitis. This lesion was associated with nodular prostatic hyperplasia in 38 cases (71.5%) and with prostatic carcinoma in one case (2%), and occurred alone in 14 cases (26.5%). The histogenesis, clinical aspects, management and prognosis of this condition are discussed in the light of current literature.

Adult↗
PubMed1985

Morphological changes in human myocardium during permanent pacing.

We have reviewed 74 cases of patients with permanent pacing, using different types of pacing leads in order to determine what morphological changes are produced by this therapy. Macroscopic examination of the heart was performed and slides at the implantation site reviewed when available. Severe chronic inflammation, scarring and a myocardial response were the prominent findings. From a strictly morphological aspect, the initial trauma at implantation time, the chronic foreign body reaction and myocardial response to chronic trauma, are both much less significant in endovenous than in epimyocardial pacing.

Abscess↗
PubMed1985

[Emergency cardiac pacing via a coronary vessel during percutaneous coronary angioplasty].

Percutaneous coronary angioplasty (PCA) is sometimes complicated by bradyarrhythmias necessitating emergency temporary cardiac pacing. This is usually performed by the classical transvenous endocardial approach. This experimental study investigated the possibility of using the metallic guide wire used during PCA as a monopolar electrode. Systematic electrical stimulation at different levels of the coronary arteries in 6 anaesthetised pigs showed threshold levels in the distal segments of 3 to 15 mA, close to the values observed in the right ventricule. Short periods of pacing were well tolerated. On the other hand, prolonged pacing (2 to 5 days) invariably led to the formation of a thrombus in the coronary segment occupied by the metallic guide wire and so should be avoided. This study shows that the metallic guide wire can be used as an emergency pacing electrode during PCA but this should be limited to a short period. This technique could replace the systematic introduction of classical transvenous pacing catheters.

Angioplasty, Balloon↗
PubMed1985

Lymphadenopathic form of Kaposi's sarcoma (KS) in an African child. No evidence for acquired immunodeficiency syndrome (AIDS).

A nine-year-old boy from the Central African Republic presented with an enlarged cervical lymph node. Biopsy revealed Kaposi's sarcoma. Lymphocyte subsets and reactivity to all antigens tested were normal, and the patient's serum contained no antibodies against LAV or HTLV3, the viruses presumably responsible for AIDS. We conclude that in this case, the lymphadenopathic form of Kaposi's sarcoma was not related to AIDS.

Antibodies, Viral↗
PubMed1984

[Hypertrophic cardiomyopathy. Apropos of 3 cases].

Three cases of hypertrophic cardiomyopathy are described. The first case, a man aged 17 years, died suddenly, while the second case was diagnosed in a 40-year-old male who presented with auricular fibrillation; this patient died two years later from a cerebral tumour. The third patient, who died at the age of 72 years from cerebral haemorrhage, had had a pacemaker inserted five years previously because of atrioventricular block. The cardiomyopathy was diagnosed only at autopsy. The morphological features of the heart in these cases are documented. The characteristic histological aspect of the myocardial fibres, commonly referred to as disarray, is described and our findings are compared with those in the literature. The relationship between the various morphological presentations and their clinical manifestations is discussed.

Adolescent↗
PubMed1983

Calcified left ventricular aneurysm in a 6-year-old boy. Case report.

The case of a calcified left ventricular aneurysm in a 6-year-old asymptomatic boy is presented. The anomaly was discovered on a routine chest X-ray. The etiology of this condition is discussed. A review of the literature reveals that this is a rare occurrence in children and that the origin is often unknown. Selective left coronary arteriography showed no arterial anomalies but early filling of the right coronary veins, apparently through small AV fistulas. This might have caused some peripheral myocardial underperfusion, followed by myocardial infarction and aneurysm formation. Aneurysmectomy was carried out uneventfully.

Calcinosis↗
PubMed1983

Extraskeletal myxoid chondrosarcoma. A case report with histochemical and ultrastructural features.

The case of an extraskeletal myxoid chondrosarcoma in a 65-year-old male, localized in the lower right thigh, is presented. The histological, histochemical, and ultrastructural features of this rare tumour are described and compared with those of the pertinent literature. The value of histochemical methods as an aid in differentiating this tumour from other malignant myxoid tumours of soft tissue is emphasized.

Aged↗