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Biomedical subjects

J Mueller

Publications and source records attributed to J Mueller.

At least 163 records · Page 9Linked to original sources
PubMed1985

Effects of fructose feeding on lipid parameters in obese and lean, diabetic and nondiabetic Zucker rats.

Effects of fructose feeding in moderate amounts on lipid metabolism of obese versus lean, and diabetic versus nondiabetic Zucker rats, were studied. Forty pairs of male lean and obese animals were assigned to two dietary groups, fructose and glucose. For each diet, one-half of lean and obese animals were injected with streptozotocin intraperitoneally (i.p.) to induce diabetes, and the other half were injected with buffer i.p. as a nondiabetic control group. After 9 wk of feeding, animals were fasted overnight, decapitated and exsanguinated. Organs were removed and weighed. Blood glucose, insulin, lactic acid, triglycerides, cholesterol, total liver lipids and urinary glucose were determined. Hyperphagia was observed in obese, non-diabetic and lean-diabetic animals. Streptozotocin injection drastically reduced insulin levels, and produced an impairment of growth, hyperglycemia, glucosuria, polydipsia and polyuria. Fructose feeding increased organ weights in kidney, liver and retroperitoneal adipose tissue, regardless of diabetic state. However, lactic acid levels were lower in fructose-fed groups than glucose-fed groups. In obese rats serum triglyceride levels were also lower in fructose-fed groups than in glucose-fed groups. Serum cholesterol was not affected by fructose feeding. The results indicated that fructose feeding did not produce hyperlipemia and lactic acidosis in the blood circulation in Zucker rats. However, fructose feeding did not improve glucose intolerance in diabetic animals, rather fructose feeding produced hyperinsulinemia in nondiabetic, obese animals.

Animals↗
PubMed1985

Improving agency productivity.

The home care industry is being challenged by many changes, most notably an abrupt reorientation in HCFA reimbursement policy. One way agencies can combat the dwindling flow of funds is to improve labor productivity by performing more home visits with the same staff. Health care professionals have not traditionally embraced this concept, but the emphasis on cost containment makes "productivity-mindedness" a requirement. A sensitive, open process will help staff realize that quality of care and and cost-consciousness are not mutually exclusive. Carefully structured productivity tools can help provide agencies with the information they need to make better plans and decisions. A productivity improvement program, carefully planned and implemented by enlightened, enthusiastic management in cooperation with staff, can provide agencies with the benefits of improved efficiency. Such a program also provides agency leaders with the means to turn the challenge of providing quality care with fewer resources into new agency opportunities.

Efficiency↗
PubMed1984

Comparison of the extrahepatic bile duct size measured by ultrasound and by different radiographic methods.

The present prospective study was done to compare the size of the extrahepatic bile duct as measured by ultrasound with those measured by different radiographic techniques. The sonographic diameters were significantly correlated to the diameters measured by intravenous cholangiography (r = 0.92), to the diameters measured by endoscopic retrograde cholangiography (r = 0.81), and to the diameters measured by percutaneous transhepatic cholangiography (r = 0.85). The mean radiographic diameters were significantly greater for intravenous cholangiography, endoscopic retrograde cholangiography, and percutaneous transhepatic cholangiography than the mean sonographic diameters. Analyzing the regression lines between the radiographic and sonographic diameters and studying the sonographic diameters during intravenous cholangiography, the discrepancy between sonographic and radiographic measurements appears to be due to several factors: (a) radiographic magnification, (b) choleretic effects in intravenous cholangiography, (c) sonographic minification, (d) dilatation of the extrahepatic bile duct due to direct injection of a contrast agent in endoscopic retrograde cholangiography and percutaneous transhepatic cholangiography, and (e) premedication in endoscopic retrograde cholangiography and percutaneous transhepatic cholangiography. Because the normal size of the extrahepatic bile duct is not usually assessed in healthy subjects by intravenous cholangiography, endoscopic retrograde cholangiography, and percutaneous transhepatic cholangiography, the mean diameter and the upper normal limit of the extrahepatic bile duct were calculated for intravenous cholangiography, endoscopic retrograde cholangiography, and percutaneous transhepatic cholangiography using previous sonographic data from healthy subjects and the present regression lines. The calculated upper limit for normal was 7-8 mm in intravenous cholangiography and 10-11 mm in endoscopic retrograde cholangiography and in percutaneous transhepatic cholangiography.

Bile Ducts↗
PubMed1983

A demonstration of the cost benefits of case management services for discharged mental patients.

The authors report on a demonstration of the cost benefits of case management for hospitalized mental patients discharged from a New York State Community Mental Health Center to community living in a rural catchment area. Case managers promoted social rehabilitation and maximized time spent in the community. Comparison of the treatment group with matched controls on frequency and duration of rehospitalization during the 15 month intervention period shows a benefit conservatively estimated as 2.03 to 2.72, depending on size of case load.

Adult↗
PubMed1983

Hyperviscosity-induced dementia.

Dementia was the presenting symptom in a patient with increased serum viscosity secondary to multiple myeloma. Plasmapheresis led to complete resolution of the neurologic syndrome. Serum hyperviscosity should be added to the growing list of reversible causes of dementia. When hyperviscosity-associated dementia is suspected, both serum and whole blood viscosity determinations are indicated.

Aged↗
PubMed1980

Effects of cimetidine and pirenzepine on peroperative electrical vagal stimulation of gastric acid secretion.

Atropine and an eightfold greater amount of pirenzepine inhibit pentagastrin-stimulated secretion to nearly the same extent (70-75%). Neither drug influences acid concentrations markedly (18%). Atropine and pirenzepine decrease the potassium concentration of gastric juice. By increasing electrical vagal stimulation the inhibitory effect of cimetidine decreases. In contrast, inhibition of vagally stimulated secretion by pirenzepine or by atropine averages 45%, when vagally stimulated secretion amounts to more than 50% of the pentagastrin-stimulated secretion. Thus pirenzepine inhibits gastric secretion similarly to atropine. These results support the hypothesis of a histamine and a cholinergic receptor.

Adult↗
PubMed1978

Surgical treatment of displaced supracondylar fractures of the humerus in children. Analysis of fifty-two cases followed for five to fifteen years.

Long-term review of fifty-two displaced supracondylar humeral fractures in children treated by open reduction and crossed Kirschner-wire fixation demonstrated functional results similar to those obtained by closed methods, but fewer and milder cases of cubitus varus deformity (only 25 per cent of patients). The deformity appeared to result from faulty reduction with medial angulation of the distal fragment. Surgical treatment of these fractures may offer, as its principal advantages: reduced hospitalization time, fewer sequelae, more stable fixation, and slightly better anatomical results. No infections or other specific complications (such as myositis ossificans or Volkmann's contracture) were encountered.

Adolescent↗