[Present status of malaria].
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Biomedical subjects
Publications and source records attributed to J Mouchet.
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Experiments were carried out in a village on the Kenya coast to investigate observed differences in pupal productivity of Aedes aegypti breeding in indoor pots. Daily addition of maize gruel, the staple food of villagers, to pots of high and low mosquito production promoted an increase of pupal numbers, although daily introduction of first-instar larvae did not significantly affect pupal production. Differences in pupal productivity were not related to differences in the numbers of eggs laid in the pots. Predation and overcrowding did not seem important in regulating the preimaginal stages. It was concluded that food, especially maize gruel accidentally introduced into the pots by villagers, was the key factor which regulated population size. As numbers of eggs are always considerable, genetic control of Ae. aegypti can be successful only when it reduces egg hatchability to a very low level. The prospects of controlling Ae. aegypti by means of health education and/or environmental management are discussed.
During a longitudinal survey done in the degraded forest area south of Brazzaville (People's Republic of the Congo), it appeared that plasmodic index of preschool children was always lower than 50% in spite of an inoculation rate of about one infected bite per child per night all along the year. The actual incidence rate estimated with Muench model was ĥ = 0,015 while the recovery rate was r = 0,032 (i.e. about three times faster than the usual values admitted since Mac Donald work) for young children (0 to 4 years old). A computer study has shown that an incidence of h1 = 0,0012 was enough for the "infection" of children (Ross model) while an incidence of h2 = 0,0014 would induce a situation of superinfection (Dietz et al. model). Therefore the actual incidence was 10 to 12 times higher than the critical values of the incidence rate. To decrease the malaria transmission at a level lower than the critical values i.e. to obtain a reproduction rate below I the calculations and graphs have shown that anopheline density or human gametocytaemia have to be reduced by about 90% while the survival rate of the vectors must be reduced by about 12%. Therefore it appeared that the determination of the critical levels of every parameters of malaria transmission is a needful stage for a better planification of any malaria control programme.
The relationship between sickle cell trait and falciparum malaria was studied in the village of Djoumouna, twenty kilometers south west of Brazzaville. Malaria is characterized by a stable high intensity of transmission on the average one infective mosquito bite by night and by child contrasting with a relatively low malarial infection rate. The prevalence of carriers of an S gene (AS) does not change with age: 22.2% for children under 5 years, 22.1% for childrern between 5 and 15 years, and 22.9% in adults. Malarial infection rates are 32% in homozygous AA children under five years and 38% in AS children, an insignificant difference. Our data for this region of the Congo fail to confirm the hypothesis that the AS genotype protects the carrier against Plasmodium falciparum infection.
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