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Biomedical subjects

J Morrison

Publications and source records attributed to J Morrison.

At least 199 records · Page 11Linked to original sources
PubMed1980

Aspiration after overdosage of sedative or hypnotic drugs.

We have reviewed the charts of 329 patients admitted to our hospital because of overdosage from sedative or hypnotic agents. Of this population 11.2% were believed to have aspirated. Included in this group were 13 patients who were observed to aspirate and 24 who were suspected of aspiration because of the appearance of radiographic infiltrates associated with compatible microbiologic studies. In the observed group, seven became febrile, four were hypotensive, eight had radiographic infiltrates, three had complications, and one died. In the group suspected of aspiration, 23 became febrile, ten became hypotensive, five had complications, and none died. We believe the low mortality from aspiration in this setting justifies caution in the use of steroids and antibiotics.

Adult↗
PubMed1980

Poor antenatal attendance and obstetric performance.

A survey of attendance for antenatal care at a public hospital in Brisbane was carried out. "Poor attenders" were more likely to be young, unmarried, grande multiparous, or aboriginal, and to live in a poorer area of the City. This group comprised 6.5% of the total population, but accounted for 14.6% of all low Apgar scores, 23% of all low birth weight babies, 23.1% of all stillbirths, and 18.2% of all neonatal deaths.

Apgar Score↗
PubMed1980

Combined effect of amphotericin B and rifampin on Candida species.

Synergism with the combination of rifampin and amphotericin B in vitro has been demonstrated with a limited number of Candida strains. To extend these studies (particularly at clinically achievable levels of rifampin), we evaluated the in vitro combined activity of serial twofold dilutions of amphotericin B (0.1 to 6.0 microgram/ml) against 11 concentrations of rifampin (0.2 to 200 microgram/ml) for 40 strains of Candida: 20 Candida albicans, 7 Candida parapsilosis, 8 Candida tropicalis, 2 Candida stellatoidea, 2 Candida guilliermondii, and 1 Candida krusei by using a modified checkerboard microtitration technique. An additive or synergistic effect was seen for 45% of strains with 6.25 microgram of rifampin per ml added to amphotericin B. Whereas the minimal inhibitory concentration to amphotericin B alone was 0.4 microgram/ml or less for 50% of the strains, the percentage increased to 90 with the addition of 6.25 microgram of rifampin per ml. A similar effect was seen with killing: 25% of the strains were killed by 0.4 microgram or less of amphotericin B alone per ml, and 75% of the strains were killed with the addition of 6.25 microgram of rifampin per ml. In vivo studies are needed for confirmation of the usefulness of combined amphotericin B and rifampin therapy.

Amphotericin B↗
PubMed1980

Digitalis and myocardial infarction in man.

The use of digitalis after acute myocardial infarction is controversial. The effect of digoxin on computer-quantitated thallium-201 perfusion scintigrams (Tl-201), left ventricular (LV) ejection fraction (EF), and percentage of abnormally contracting LV regions (% ACR) was determined in 23 patients. A correlation was established between creatine kinase MB isoenzyme release and initial radionuclide-gated blood pool wall motion estimates of EF (r = -0.73) and % ACR (r = 0.71). After radionuclide assessments, 14 patients received digoxin 18 +/- 23 hours (mean +/- SD) after the rise in CK-MB from baseline, while the remaining nine patients served as controls. In the control group, the mean EF was 0.33 +/- 0.12 on the first study and 0.30 +/- 0.08 on the second study (p = NS). In the digoxin group, the EF after digoxin administration (mean 0.33 +/- 0.11) was significantly different from the initial EF (mean 0.29 +/- 0.09, p less than 0.03); however, digoxin had no apparent effect on infarct size as assessed by sequential % ACR and Tl-201 perfusion data. These data indicate that digoxin resulted in a minimal but significant improvement in EF that did not occur at the expense of LV perfusion or regional wall motion.

Adult↗
PubMed1980

Adult psychiatric disorders in parents of hyperactive children.

The family histories of 140 children and adolescents with hyperactive child syndrome were compared with the family histories of 91 psychiatrically ill, age- and sex-matched patients who had a primary diagnosis other than hyperactive child syndrome. Parents of hyperactive children were more likely to have antisocial personality and Briquet's syndrome (hysteria) than were parents of nonhyperactive children; 11% of the hyperactive children had a parent with such a diagnosis. Parents of nonhyperactive children were more likely to have endogenous psychosis. The diagnosis of alcoholism did not significantly differentiate parents of the two groups of probands. These data support earlier studies and suggest a specific association between hyperactive child syndrome and the personality disorders of antisocial personality and hysteria.

Adolescent↗
PubMed1980

Obstetric practice amongst Queensland general practitioners: a survey of needs and attitudes.

A survey of Queensland general practitioners was carried out to assess their needs and attitudes regarding obstetric practice. Less than half of the respondents now practise obstetrics, and many general practitioners felt a lack of support from specialist obstetricians, paediatricians, and anaesthetists. Many of the respondents expressed needs for further obstetric training, especially in labour ward management and neonatal care; however, few were able to attend extended courses.

Adult↗
PubMed1979

Immune thrombocytopenic purpura in Hodgkin disease.

Immune thrombocytopenic purpura is rarely seen in Hodgkin disease and the presence of platelet-associated antibody has not been previously reported in these patients. A patient with Hodgkin disease is described who developed a destructive thrombocytopenia demonstrated by shortened platelet survival. In conjunction with his thrombocytopenia, he had marked elevation of platelet-associated immunoglobulin G levels (nanograms IgG per 10(9) platelets: 15,187 prior to splenectomy and 71,130 and 81,900 after surgery). Mean values (+/-SD) of control subjects averaged 1,975 + 381 and four patients with Hodgkin disease and normal platelet counts had levels ranging from 1,581 to 4,011. We suggest that this patient had immune-mediated thrombocytopenia; whether the increase in platelet-associated immunoglobulin G was due to antiplatelet antibody or to adsorbed or phagocytosed immune complexes cannot be demonstrated by these studies. The platelet-associated immunoglobulin G test may be useful in evaluating these patients.

Antibodies↗
PubMed1979

Idiopathic hypertrophic subaortic stenosis: evaluation of anginal symptoms with thallium-201 myocardial imaging.

The evaluation of angina pectoris in patients with idiopathic hypertrophic subaortic stenosis is difficult in those in the age group prone to coronary artery disease. Ten patients with angina pectoris, normal coronary angiograms and idiopathic hypertrophic subaortic stenosis were studied with thallium-201 myocardial imaging performed in conjunction with submaximal treadmill exercise testing. The resting electrocardiogram demonstrated left ventricular hypertrophy with S-T segment abnormalities in seven patients, thereby vitiating the further increase in S-T segment abnormalities that developed in these patients during exercise or in the postexercise period. Of the three patients with a normal resting electrocardiogram, one had significant exercise-induced S-T segment depression. Thallium-201 myocardial imaging revealed no significant perfusion defects in 9 of the 10 patients (90 percent). In one patient with severe left ventricular hypertrophy significant perfusion defects developed after exercise that were not present at rest. Stress thallium-201 myocardial perfusion imaging is a useful noninvasive technique that assists in ruling out the presence of significant coronary artery disease in patients with idiopathic hypertrophic subaortic stenosis.

Adolescent↗