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Biomedical subjects

J Morenz

Publications and source records attributed to J Morenz.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Animal experiment studies of the modification of pregnancy by heterologous antibodies to placental antigens].

Pregnancy impairment in mice with abortion and fetal resorption was caused by rabbit antibodies to total mitochondrial, mitochondrial membrane and microsomal fractions of mouse placentas injected intraperitoneally at 12-14 days of gestation. Antibodies to cytosol and soluble mitochondrial constituents were ineffective. According to the marker distribution in the biologically active and inactive fractions membrane-bound antigens are thought to be responsible for the abortigenic effect.

Abortion, Spontaneous↗
PubMed1985

[Effect of drugs on granulocyte motility].

The in-vitro influence of drugs on the chemokinesis and chemotaxis of neutrophils was investigated in order to prevent additional drug-induced motility impairment of cells in cases of already existing host defense disorders and for an eventual specific treatment of motility defects. Granulocyte motility is unimpaired by penicillin, ampicillin, carbenicillin, streptomycin, nystatin, and cyclophosphamide. The chemokinesis and chemotaxis of neutrophils are inhibited by erythromycin, oxytetracycline, doxycycline, chloramphenicol, hydrocortisone, g-strophanthin, digoxin, and digitoxin and in higher concentrations also by sulfonamides, gentamycin, prednisolone, methylprednisolone, dexamethasone, and phenylbutazone. Chemotaxis is selectively or rather more inhibited than chemokinesis by amphotericin B, griseofulvin, vinblastine++, trifluoperazine, and promethazine. Granulocyte motility is, however, stimulated by ascorbic acid, potassium thiocyanate, levamisole, lithium, and metofenazate.

Anthelmintics↗
PubMed1984

Pregnancy impairment in mice by antibodies to subcellular placenta fractions.

The administration of rabbit antibodies to whole mitochondria, mitochondrial membranes, or microsomes of mice placentas at 12-14 days of gestation resulted in abortion or fetal resorption, whereas antibodies to administered cytosol, mitochondrial matrix, or the mitochondrial intermembrane fraction were ineffective. From the distribution of marker enzymes in the biologically active and inactive fractions the abortigenic antigens are thought to be membrane-associated. Because of insurmountable cross-reactivities of the heterologous antisera, the immunopathogenesis of abortion could not be adequately clarified. However, preliminary experiments with antibodies (immune ascites) from mice immunized with the mitochondrial-microsomal fraction proved successful. A homologous animal model might be more helpful in elucidating the role of antibody-mediated immune mechanisms in human pregnancy impairment.

Abortion, Spontaneous↗
PubMed1983

[Tissue bound autoantibodies in genital organs of infertile couples].

Autoimmunity may play a role in the pathogenesis of infertility. To explore this possibility biopsy specimens of ovaries, endometrium and tests from infertile couples were examined immunohistologically. Cryostat cut sections of biopsies were treated with fluorescein-conjugated antibodies to demonstrate tissue-bound IgG, IgA, IgM, IgD, C3, C4 and fibrinogen. Tissue-bound antibodies, complement or fibrinogen could be detected in 8 (13,3%) of 60 ovarian, 14 (16,3%) of 86 cervical, 18 (19,6%) of 92 corporal and 12 (14,1%) of 85 testicular biopsies. Moreover 20 (23,5%) specimens of the testicular biopsies showed fibrinogen fluorescence only.--The results suggest that autoantibodies against different genital organ antigens may be implicated in the pathogenesis of some cases of infertility.

Autoantibodies↗
PubMed1983

[Detection of humoral antibodies to genital organ antigens in sterile couples].

Sera from 150 infertile and 50 fertile couples were examined for circulating anti-genital organ antibodies by indirect immunofluorescence test on unfixed cryostat sections from various organs and methanolfixed smears of spermatozoa. -- Antibodies to spermatozoa showed an acrosomal, equatorial, postnuclear or tail immunofluorescence pattern. -- Antibodies to the ovary were directed to theca folliculi and to stromal antigens. Antibodies to the Fallopian tube reacted with the apical parts of the epithelial cells. Antibodies to endometrium and cervix were directed to glandular epithelium or mucosal stroma and antibodies to placenta reacted with trophoblast cells or amnion epithelium. Testicular antibodies were directed to tunica propria or the germinal epithelium. -- Antibodies to epididymis stained the mucous membrane epithelium, basal cells, the tunica propria or epididymal spermatozoa. Antibodies to the prostate and seminal vesicles reacted with glandular epithelium or stroma. -- Autoimmune mechanisms may play diverse roles in the pathogenesis of dysfunction of female and male genital organs.

Adult↗
PubMed1983

[Detection of organ-specific and organ non-specific autoantibodies in the serum of sterile couples].

Sera from 150 infertile and 50 fertile couples were examined for organ-specific and non-organ-specific antibodies by indirect immunofluorescence tests on unfixed cryostat sections. Adrenocortical antibodies to zona fasciculata cells were found in 4 females and 2 males of infertile couples. Parietal cell antibodies were demonstrated in 4 females and 2 males of infertile couples. Parietal cell antibodies were demonstrated in 4 female and 3 male sera. Antibodies to mitochondria could be found in 14 fertile and 72 infertile couples. Antinuclear antibodies occurred in 2 fertile and infertile couples. Smooth muscle antibodies were found more often in infertile than fertile couples. Glomerular, skeletal muscle and reticulin antibodies were detected only in infertile couples. The detection of autoantibodies can help to elucidate immune reactions causing infertility.

Adrenal Cortex↗
PubMed1981

Immunological factors in human male infertility: immunopathological studies of testes.

Biopsy specimens of human testes from 190 men of infertile couples were treated with fluorescein-labelled antibodies to demonstrate tissue-bound IgG, IgA, IgM, IgD, C3, and C4. In 24 cases (12.6%) autoantibodies and/or complement could be detected. Most often IgG bound to walls of seminiferous tubules was found. Three men had antibodies or complement in germinal cells. In one case each IgA immunofluorescence was found in spermatids or Leydig cells. The results suggest that autoantibodies to testicular antigens may be implicated in the pathogenesis of some cases of infertility in man.

Adolescent↗
PubMed1980

[Immunopathogenesis of cytotoxic antibody-mediated autoimmune diseases].

This review deals with autoantibodies, autoantigens, immunopathogenetic mechanisms and their consequences in autoimmune diseases caused by cytotoxic antibodies. Findings demonstrating the pathogenicity and pathogenic potency of antibodies, the involvement of complement and polymorphonuclears, and the chain of events leading from the start of immune reactions to clinical signs and symptoms are stressed. It is shown that the immunopathogenesis of this group of diseases can be deduced from only a few related immune mechanisms while the heterogeneity of clinical syndromes can be explained primarily by the function and localization of autoantigens. Questions still open and findings not yet understood are pointed out. From the progress of immunology in recent years further diseases can be expected to be recognized as type II autoimmune diseases in the years ahead notably by the combined application of immunological and physiological or pharmacological methods.

Anemia, Hemolytic, Congenital↗