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Biomedical subjects

J Moore

Publications and source records attributed to J Moore.

At least 667 records · Page 37Linked to original sources
PubMed1976

Gold nephropathy. Ultrastructural, fluorescence, and microanalytic studies of two patients.

Renal biopsy specimens from two patients with gold nephropathy showed two distinctly different types of alterations. The first demonstrated lesions suggestive of immunologic injury primarily to the glomerulus and identical with membranous glomerulonephritis. The second had no evidence of immunologic injury, but contained extensive vacuolar degeneration of proximal tubular epithelial cells. Ultrastructurally, the vacuoles contained lipid materials and occupied the basal portion of the cells. Other tubular cells contained numerous "gold-containing" cytosegresomes. In this second specimen, it appeared that the filtered gold had a direct toxic effect on the tubular epithelium and perhaps also on the glomerular capillary wall. These findings suggest that gold nephropathy may indeed be a spectrum of a combination of both direct toxic and immunologic injury to glomeruli and tubules.

Aurothioglucose↗
PubMed1975

A placebo-controlled study of lithium combined with neuroleptics in chronic schizophrenic patients.

Lithium combined with major tranquilizers was administered to 22 hospitalized chronic schizophrenic patients with minimal neurotoxicity or other side effects. Moreover, 10 of the patients benefited significantly with lithium as compared to placebo in terms of blind psychiatric and nursing ratings and nonblind clinical judgments of outcome. These results contrast with previous negative reports in the literature and the generally poor prognosis in chronic schizophrenic patients. The authors suggest that a trial combining lithium with psychotropic drugs is warranted in schizophrenic patients who do not respond satisfactorily to conventional treatment

Adult↗
PubMed1975

Choice and response contingencies.

Two experiments investigated the extent to which response contingencies influence the choice between two schedules of reinforcement by exposing pigeons to a concurrent-chains procedure in which reinforcers in one terminal link were response-independent, and in the other terminal link, response-dependent. In Experiment 1, the pigeons were indifferent between an aperiodic, response-independent schedule and an aperiodic, response-dependent schedule that required a minimum rate of responding. This finding limits the generality of a required-rate contingency as a determinant of choice, which contingency had been previously demonstrated in a context of periodic reinforcement to evoke preference for an alternate schedule. In Experiment 2, the pigeons preferred a periodic, response-independent schedule to a periodic, response-dependent schedule that shared a feature with a required-rate schedule: there was a requirement to respond early in the interreinforcement interval, when responding produced reinforcement only later. The results of the two experiments suggest the following general interpretation: pigeons prefer a second schedule to the extent that the response contingencies of the first schedule must be satisfied during discriminable periods of nonreinforcement.

Journal Article↗