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Biomedical subjects

J Mitra

Publications and source records attributed to J Mitra.

At least 91 records · Page 5Linked to original sources
PubMed1981

Sister chromatid exchanges in vivo in mouse mammary adenocarcinoma.

The proliferation and genetic characteristics of a mouse mammary adenocarcinoma designated dbrB are described. This tumor was maintained as subcutaneous serial transplants in syngeneic inbred mice of the DBA/1J strain. Quantitative in vivo sister chromatid exchange(s) (SCE) were determined in the tumor cells and in the bone marrow cells of the host strain. Over a twofold increase in SCE, frequency was noted in the dbrB tumor cells compared to the bone marrow cells. The high frequency of SCE in the dbrB tumor was assumed to be caused by the high degree of malignancy of this tumor. Such information indicating genetic stress may serve for evaluation of the degree of malignancy in neoplasms.

Adenocarcinoma↗
PubMed1978

Chromosomal evidence for the transplantability of the Shay chloroleukemia.

Chloroma cells, which were shown to contain the X and Y chromosomes, were used to induce Shay chloroleukemia (SCL) in female recipients. Karyotype analyses of leukemic myeloblasts which appeared in the peripheral blood of the female recipients during blast crisis demonstrated invariably the presence of the X and Y chromosomes. These results directly demonstrate that transmission of SCL is the result of donor cell colonization and therefore SCL can be considered a true transplantable leukemia. Reports by other workers of viral association with this disease are discussed in light of our results.

Animals↗
PubMed1975

Effects of hippocampal afterdischarges on Purkinje cell activity.

Hippocampal afterdischarges can induce increased Purkinje cell activity that characteristically shows a pronounced acceleration during the period of the afterdischarges. Increased Purkinje cell activity may continue for many seconds after termination of the hippocampal activity. Typical frequency histograms are presented. A short period of hippocampal afterdischarges (under 25 sec) may occur with few if any alterations in cerebral activity and vice versa. However, such afterdischarges can produce changes in cerebellar activity as shown by enhanced Purkinje cell activity. These data support the view that the nucleus tegmenti pontis may be prominently involved in relaying hippocampal afterdischarges to the cerebellum whereas much of the neocortical seizure activity is relayed trough the pons, inferior olive, and lateral reticular nucleus, rather than through nucleus tegmenti pontis. EEG tracings taken from these areas illustrate the findings.

Action Potentials↗