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Biomedical subjects

J Michel

Publications and source records attributed to J Michel.

At least 163 records · Page 9Linked to original sources
PubMed1980

Detection of penicillins in the sera of 'healthy' blood donors.

10,853 sera, collected from 'healthy' blood donors during the period December 1977 to May 1979, were tested for the presence of penicillinase-sensitive penicillins by a bioassay technique using Bacillus subtilis ATCC 6633 as test organism. Their presence could be demonstrated in 30 sera (0.27%), at concentrations equivalent to 0.2--4.0 micrograms/ml of penicillin G. The implications of these findings are discussed, particularly the possibility of their relationship to nonhemolytic adverse reactions to transfusion.

Bacillus subtilis↗
PubMed1980

Presence of aspirin in blood units.

2,655 blood units collected from healthy voluntary donors selected according to the criteria of the International Society of Blood Transfusion were tested for the presence of aspirin. This drug was found in 6% of the samples at concentrations ranging from 10 to 200 microgram/ml. The clinical implications of these findings are discussed. We also report a case of allergic reaction which could probably be related to the transfusion of blood containing aspirin.

Adult↗
PubMed1980

Effects of subminimal inhibitory concentrations of Erythromycin, Clindamycin, and Pristinamycin on the penicillinase production of Staphlyococcus aureus.

The influence of subminimal inhibitory concentrations of erythromycin, clindamycin, and pristinamycin on the penicillinase production of Staphylococcus aureus was tested in 12 strains. Of the 36 experiments performed, 16 (44%) showed a lack of influence, 10 (28%) displayed an increase, and 10 revealed a decrease in penicillinase activity. The maximal effect produced was generally induced by concentrations ranging from 1/4 to 1/32 the minimal inhibitory concentration, irrespective of the susceptibility of the strain to the drug. In spite of the fact that the drugs are closely related, they sometimes produced opposite effects on the same strain.

Anti-Bacterial Agents↗
PubMed1980

Effect of an R plasmid on the virulence of a hospital strain of Escherichia coli.

The virulence of a multiple antibiotic-resistant isolate of Escherichia coli was compared to that of the same isolate 'cured' of its resistance by acridine orange, and to that of the cured bacteria transformed back to resistance by the plasmid DNA extracted from the original resistant isolate. There were virtually no differences in the mouse LD 50 of these three variants of the same organism.

Animals↗