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Biomedical subjects

J Meynadier

Publications and source records attributed to J Meynadier.

At least 127 records · Page 7Linked to original sources
PubMed1983

Neutrophil chemotaxis in psoriasis before and after PUVA therapy.

Chemokinesis and chemotaxis of neutrophil leucocytes were studied by migration under agarose in 35 patients with psoriasis and compared with 35 healthy controls. Eschericheae coli filtrate and lipopolysaccharide were used as chemo-attractants. Of these patients, 14 were tested before and after photochemotherapy. The chemotactic capacities of psoriatic serum before and after PUVA therapy were also investigated. The increase in the chemotactic activity of psoriatic polymorphonuclear leucocytes (PMNs) was not significant and remained unchanged after PUVA therapy. The activated psoriatic serum showed a slight increase in chemotactic activity when compared with normal activated serum. These results do not support an intrinsic abnormality of psoriatic PMNs, and their migration into psoriatic lesions could be chiefly due to the presence of chemotactic factors in involved epidermis.

Adolescent↗
PubMed1982

Somatostatin treatment of psoriasis.

Somatostatin treatment was administered to 20 psoriatic patients according to the following protocol: Continuous infusion (250 micrograms/h) for at least 2 days followed either by short infusions (1 h) at 8 A.M. and 8 P.M. (12 cases) or by repeating the initial 2-day infusion (eight patients). Before treatment (day 0) and on day 6, biopsy specimens were taken for routine examination (12 patients) and for ultrastructure (seven patients). In vitro immunological studies were carried out on peripheral blood lymphocytes (six patients) on day 0 and day 8. In two patients, somatostatin was stopped because of serious side effects. Thus, clinical results were evaluated in 18 patients, on day 30. In ten of them no improvement whatsoever occurred, two had a partial clearing and an almost complete remission was achieved in six others. Ultrastructural studies showed, on day 6, enlargement of the intercellular spaces with deposits of granular material of glucidic composition, associated with features of cellular damage. Percentages of T and B cells were unmodified but a significant depression of mitogenic stimulation by PHA and ConA was clearly observed on day 8. Even if somatostatin treatment may have a beneficial effect in some patients it seems much less valid than other well-known therapies for psoriasis.

Adult↗
PubMed1982

Cyclic AMP and cyclic GMP production in normal and psoriatic epidermis.

cAMP and cGMP production was determined in normal and psoriatic (involved or uninvolved) epidermis. After homogenization, epidermal strips were incubated with saturating concentrations of ATP or GTP, respectively, for cAMP and cGMP production. Cyclic nucleotides were measured by radioimmunoassay before and after 5, 10, 20 min of incubation. The kinetics of cAMP and cGMP production were linear during the 20 min of incubation. Comparison of normal skin, uninvolved and involved psoriatic skin, prior to and after 20 min of incubation showed the following results: cAMP levels were significantly higher in normal skin than in psoriatic skin at zero time (p less than 0.01) and after incubation (p less than 0.05). cGMP levels were not significantly different in the three tissues at zero time. After incubation, psoriatic involved epidermis exhibited a higher production of cGMP than normal skin (p less than 0.05). Thus, the ratio cAMP/cGMP was higher in normal skin than in psoriatic skin at the basic level (p less than 0.05) and after incubation (p less than 0.01). These results indicate an imbalance in cyclic nucleotides metabolism in psoriatic skin without a significant difference between uninvolved and involved epidermis.

Adenosine Triphosphate↗
PubMed1982

[Allergy to preservatives].

This study concerns 465 patients with dermatitis. The clinical history suggested allergy to cosmetics, drugs, industrial products or clothes. These patients were tested with 29 preservatives chosen among the most frequently employed or most sensitising products. Seven french clinics of Dermatology were involved in this study during one year. The patients' age varied between 2 years old and 80 years old. Positive reactions were seen mostly with formaldehyde (4.7 p. 100), Bronopol (4.7 p. 100), ammoniated mercury chloride (3.8 p. 100), benzoic acid (2.1 p. 100), sodium benzoate (1.9 p. 100), parabens (1.9 p. 100), dichlorophen (1.7 p. 100), chloracetamid (1.5 p. 100), benzyl benzoate (1.5 p. 100), Germall 115 (1.2 p. 100), butylhydroxyanisol (1 p. 100) and Dowicil (0.8 p. 100). The incidence of sensitivity to formaldehyde, Bronopol, ammoniated mercury chloride is too high; their use should decrease. Patients sensitive to benzoic acid, benzyl benzoate are not rare. Chloracetamid whose frequency of uses seems to be rather low is a very sensitising product. Parabens which are widely used were seldom found positive; nearly all cases are caused by topical medications.

Adolescent↗
PubMed1982

[Contact urticaria in atopic patients. Apropos of 2 cases].

Contact urticaria appears half an hour after application of allergens on skin area of contact. It is favoured by atopy. Two cases are reported. 16-years-old boy had dermatitis of perioral area, hands and more slightly nape of the neck with urticaria due to local application of potato, carrot and apple. Avoiding those allergens cleared urticaria and dermatitis. 45-years-old woman had face and hands dermatitis associated with contact urticaria to potato and banana on those areas. She had cold urticaria as well. A positive passive transfer (Prausnitz-Küstner) was only seen with potato and banana. It is likely that contact urticaria in the atopics is still under-estimated. Scratching may probably lead to dermatitis. Dermatitis of these two patients could be explained by this way.

Adolescent↗
PubMed1981

[Erythemas].

Explore the source record for details and available documents.

Adult↗
PubMed1981

Immunofluorescence in psoriasis: studies of immunoglobulins, complement deposits, and three membrane markers.

Sixteen psoriatic patients and 11 control subjects were investigated by immunofluorescence for skin immunoglobulins (IG) and complement (c) deposits and for keratinocyte membrane markers with anti beta 2 microglobulin (beta 2 m) antibodies (Ab), Con A, and pemphigus Ab. IG and/or c deposits were almost constant in involved epidermis. Three patterns were associated: (1) parakeratotic nuclear (dots-dashes), (2) stratum corneum (SC) intercellular (lamellar pattern), (3) vascular (granular or linear deposits in papillary dermal vessels). In uninvolved epidermis nuclear or vascular deposits could occasionally be present but intercellular pattern was never found in SC. Control specimens were always negative. The three surface markers investigated (beta 2 m, Con A receptor, Pemphigus antigen) could be demonstrated on psoriatic keratinocytes with only slight differences in distribution when compared with controls. Thus, by this methodology no important abnormality could be found in psoriatic keratinocyte membrane antigens.

Cell Nucleus↗