TIPS patency can be assessed by different imaging techniques: angiography, color Doppler sonography, CT angiography, scintigraphy. Percutaneous angiography with measurement of the portocaval pressure gradient is the gold standard in the diagnosis of shunt failure, but, because its invasive nature and the necessity of frequent control of the shunt function, a noninvasive procedure is preferable for routine checkup. Color Doppler sonography in intervals of 3 to 6 months, with the use of different criteria, is considered as an accurate imaging technique with a high degree of sensitivity and specificity to evaluate TIPS patency. Angiography is indicated when CDS is not successful or in each clinical recurrence. Revision procedure may restore shunt efficiency and is indicated when the TIPS patency is compromised.

Follow-Up Studies↗

PubMedDate not supplied

Effects of selenium supplementation on malignant lymphoproliferative pathologies associated with OF1 mouse ageing.

Low plasma selenium (Se) levels have been shown to correlate with increased cancer incidence in humans and in mice. This study was undertaken to investigate the ability of Se to decrease mortality rate and tumor production in ageing mice. Se (2.5 ppm) given as sodium selenite in drinking water to 8 months old OF1 mice, for 4 consecutive months, reduced significantly the mortality of mice with 6% and 50% mortality rate for Se and control groups, respectively. In addition 80% of control deaths resulted from a lymphoid cell neoplasma, while no one of Se supplemented mice produced tumor. Evaluation of parameters of free radical metabolism showed highly significant reduction of the antioxidant defence system in the liver of cancer mice, with a 78% decrease in GSH-Px activity, a 65% decrease in superoxide dismutase (SOD) activity, a 75% decrease in the GSH/GSSG ratio and a 62% decrease of plasma Se level, as compared to healthy old mice. Nevertheless in the conditions of our experiment, Se didn't really improve the endogenous antioxidant status of ageing mice.

Aging↗

PubMedDate not supplied

[Absence of in vitro reaction between 2,4,6-triiodo-3-carboxanilide (Biligram) and paraprotein IgM].

Explore the source record for details and available documents.

Aged↗

PubMedDate not supplied

[The reproduction of families affected by Steinert's dystrophy in Saguenay (Quebec), 1885-1971: demographic parameters].

"In the light of the literature in the field, one would expect that the myotonic dystrophy (or Steinert) gene carries a severe selective disadvantage. Indeed, this phenotype is commonly said to entail...sterility, infant mortality, and a lower nuptiality. In the worst cases, it is not unlikely that the gene could eliminate itself through non-reproduction. [A model is developed and] tested in the Saguenay (Quebec) population, known for its exceptionally high prevelance (1/475) of the disease. Authors have been able to use a computerized demographic and genealogical data base in order to study several demographic variables (fertility, nuptiality, mortality, etc)....Case-control analyses produced very [few] differences between affected and control families, suggesting no significant selective disadvantage associated with the gene." (SUMMARY IN ENG AND ITA)

Americas↗

PubMedDate not supplied

[Preliminary results on the residence distribution at birth of patients with Alzheimer's disease in the Saguenay-Lac-Saint-Jean/Quebec (the IMAGE project)].

The IMAGE Project is pursuing the establishment of a population-based registry of Alzheimer's disease (AD) cases in the Saguenay-Lac-Saint-Jean (SLSJ) (Quebec). The authors report on the spatial distribution at birth of 221 possible, probable and definite cases. A large network of key-informants for screening AD cases has been established over SLSJ. The spatial distribution of cases at birth and at the onset of disease has been computed by calculating the Alzheimer birth rate (ABR) on the basis of three scales: six specific geographical spheres of screening, all municipalities, and the public health departments. The statistical significance of results was determined using the theoretical Poisson and the Chi square distributions. ABR for each of the geographical spheres of screening showed no statistically significant differences considering either residence at the onset of the disease or residence at birth. Furthermore, differences were observed between rural and urban areas with an interesting trend for a higher number of cases than expected in one area of SLSJ. The spatial distribution of cases considered on the basis of residence at birth appears to show a different pattern, but no significant, from that measured on the basis of residence at the onset of disease. Screening of cases is actively being pursued all across SLSJ by the IMAGE network. There is a clear trend towards rural residence at birth of cases. It remains to see whether or not this observation is due to a geographical concentration of familial cases.

Alzheimer Disease↗

PubMedDate not supplied