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Biomedical subjects

J Marks

Publications and source records attributed to J Marks.

At least 217 records · Page 12Linked to original sources
PubMed1977

Methods and medium for the culture of tubercle bacilli.

A brief account is given of methods recommended for the culture of tubercle bacilli and improved media are described appropriate for each. The chief changes suggested are reductions in the phosphate and dye content of media previously devised for alkaline inocula.

Bacteriological Techniques↗
PubMed1977

Differential tuberculin test for mycobacterial infection in children.

A composite antigen prepared from strains of M. avium, M. intracellulare and M. scrofulaceum has been used in addition to PPD in differential skin tests, principally on children investigated for mycobacterial cervical adenitis. The tests were uniformly successful in 12 cases bacteriologically positive for opportunist mycobacteria and gave unequivocal positive or negative results in 30 cases awaiting diagnosis.

Antigens, Bacterial↗
PubMed1977

Physiology of abnormal movements.

The units of the central nervous system controlling voluntary movement are described and the roles of the motor and sensory cortex, of the basal ganglia and cerebellum and of the final common loop are outlined. The pathophysiology underlying disturbances of movement, power and tone of the limbs is discussed, with particular reference to the more common dyskinesias.

Basal Ganglia↗
PubMed1976

A system for the examination of tubercle bacilli and other mycobacteria.

Methods are described for the examination of mycobacteria cultured from clinical specimens. In the "screening" procedure used for new isolates tubercle bacilli are non-pigmented, do not grow at 25 degrees C and are sensitive to p-nitrobenzoic acid as well as normally to anti-tuberculosis drugs. Classification is extended when necessary by the use of four tests--temperature requirements, pigmentation, oxygen preference and Tween hydrolysis. These define 15 species or groups meeting the needs of clinical bacteriology. Drug-sensitivity tests are described which relate the end-points of titrations to the modal response of normal wild strains of M. tuberculosis. They are used not only as a guide to chemotherapy but also to support and amplify classification.

Aminosalicylic Acid↗
PubMed1976

A new practical classification of the mycobacteria.

A new classification is presented for mycobacteria cultured from clinical specimens. Five categories were defined on temperature requirement, and these were subdivided into 14 groups by pigmentation, oxygen preference and Tween hydrolysis. Support for some of the groups and for the recognition of certain important species within others was provided by drug-sensitivity tests. Less than 1-0% of the opportunist mycobacteria met in Britain eluded classification by these means.

Culture Media↗
PubMed1976

Coeliac disease and dermatitis herpetiformis: further studies of their relationship.

Using diagnostic criteria which are currently accepted as most reliable we have found that 19% (9/47) of patients with dermatitis herpetiformis (DH) have no evidence of coeliac disease. The incidence of HL-A8 in the DH patients was 78%, which is considerably greater than that in healthy controls and no different from that reported in coeliac disease. Furthermore, the incidence of HL-A8 was just as much increased in those DH patients without evidence of coeliac disease suggesting that HL-A8 is associated with DH per se--that is, regardless of its association with coeliac disease.

Celiac Disease↗
PubMed1975

Bone abscess due to Mycobacterium xenopi.

Destructive infection of a cuneiform bone due to M. xenopi is described. The organism was isolated and its significance established by a strong skin reaction to xenopi antigen and by demonstration of bacilli in the lesion with fluorescence microscopy. This evidence of metastatic disease suggests that an alimentary route of infection as an alternative to inhalation could be considered.

Abscess↗