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Biomedical subjects

J Marek

Publications and source records attributed to J Marek.

At least 235 records · Page 13Linked to original sources
PubMed1981

Effects of total fasting in obese women. IV. Response of serum triiodothyronine (T3) and reverse triiodothyronine (rT3) to administered T3.

Serum levels of T4, T3, rT3, RT3U and TSH were estimated in 12 obese women in the course of a 14-day fasting. Seven of these patients were treated with T3 in a daily dose of 60--80 micrograms. Fasting led to a small increase of serum T4, while fasting combined with T3 administration was accompanied by a small decrease of serum T4. Serum T3 decreased in the course of the first 2 days of fasting to 40--50% of initial values and remained at this low level up to the 15th day of fasting. In the T3 treated group a prompt increase of serum T3 was recorded (+80%), followed by a steady decrease, reaching the control values on day 15, in spite of a continuous T3 administration. Serum rT3 in the untreated fasting group steadily increased up to the 12th day (+43%) and then dropped below the control value (-28%). In the treated group after a non-significant increase (+22%), a decrease of serum rT3 was also observed (-42%). Fasting was accompanied by a tendency to increased serum RT3U values, in the T3 treated group no change occurred. TSH in the untreated fasting women remained practically unchanged while T3 administration was accompanied by a tendency to a transient decrease. The heart rate showed a non-significant tendency to increase in the T3 treated group and the last week of fasting was also accompanied in several patients by a larger weight loss. These results suggest that in addition to an enhanced synthesis of rT3 to the detriment of a decreased production of T3 from T4, an increased catabolism of administered T3 and of endogenous rT3 is involved in a strict calorie restriction. An abortive T3-TRH-TSH feed-back may also operate in these conditions.

Adult↗
PubMed1980

[Sotos' syndrome].

Explore the source record for details and available documents.

Abnormalities, Multiple↗
PubMed1980

Effects of single intramuscular administration of various preparations of corticosteroids on bentonite-induced oedema of rat hind paw.

Effects of single prophylactic and/or therapeutic i.m. doses of various esters of anti-inflammatory steroids on the bentonite-induced oedema of the rat paw were followed. The short-lasting actions (1 d) of soluble sodium succinate esters of hydrocortisone, prednisolone and 6-methylprednisolone on the one hand, and the long-lasting actions (1 to 2 weeks) of insoluble hydrocortisone acetate, 6-methylprednisolone acetate or cyclopentylpropionate, and triamcinolone diacetate or acetonide on the other hand have been proved. Both the preparations of beta-methasone tested exerted short-lasting effects (1 d). It has been confirmed that triamcinolone acetonide is more effective (and also more toxic) than the diacetate ester of this steroid. The bentonite-induced oedema has proved to be a suitable model of inflammatory reaction for screening anti-inflammatory corticosteroids because it makes possible the determination and differentiation of the time of onset, intensity and duration of action of single doses of various pharmaceutical formulations of these agents.

Animals↗
PubMed1979

Bone isoenzyme of serum alkaline phosphatase in acromegaly.

In 37 patients with active acromegaly and in 15 patients with inactive acromegaly, activity of bone isoenzyme of serum alkaline phosphatase correlated (P less than 0.001) with serum concentration of immunoreactive growth hormone. By using stepwise regression analysis, the predication of serum growth hormone values based on serum levels of bone isoenzyme of serum alkaline phosphatase, gamma-glutamyl transferase and calcium in these patients with acromegaly was within 1 S.D. range in 37 patients and in only 2 patients was it out of 2 S.D. range. By using discriminant analysis, based on bone and liver isoenzymes of serum alaline phosphatase and urinary hydroxyproline excretion, 87%, 60% and 97% of the classification of patients with active and inactive acromegaly and healthy adults, respectively, was correct. The multivariate approach offers a quantitative appraisal of the biochemical parameters of peripheral growth hormone action used as an indicator of growth hormone concentration in patients with acromegaly.

Acromegaly↗
PubMed1979

["Giant" oncocytic renal adenomas].

Postmortem and bioptic material from the 1953-1976 period included 7 cases of oncocytic renal adenoma larger than 5 cm including 3 larger than 10 cm. Macroscopic characteristics included red-brownish coloration and extensive foci of central hyalinosis. Microscopy showed them as being made up of cells resembling oncocytes with relatively active nuclei with solid, occasionally focus-like tubular structure. In spite of the large size and, in some rarer cases, focal nuclear atypia all of the tumours appeared to behave in a benign way. The causes of their increased frequency in the past decade remain to be clarified yet.

Adenoma↗