Biomedical subjects

J Malec

Publications and source records attributed to J Malec.

78 records · Page 5Linked to original sources

PubMedDate not supplied

Protection against hydroxyurea-induced cytotoxic effects in L5178Y cells by free radical scavengers.

Exposure of L5178Y cells in culture to 1 mM hydroxyurea (HU) for 3 h followed by 24 h incubation in an HU-free medium induced an abnormal enlargement of about 40% of the cells in the population and post-treatment reduction of DNA synthesis in comparison with control cells. These effects were used to examine the protection afforded by free radical scavengers against HU-induced cytotoxicity. It has been found that with careful choice of conditions (suitable concentration of the protective agent, pretreatment of cells) substantial protective effect of alpha-tocopherol, sodium benzoate, acetylsalicylic acid, catalase, peroxidase or superoxide dismutase can be achieved.

Animals↗

PubMedDate not supplied

[The role of oxygen free radicals and antioxidants in toxic side effects of antineoplastic chemotherapy and their prevention].

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Antioxidants↗

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[Oncogenic viruses and prospects for treatment of leukemia].

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Animals↗

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[Separation of peripheral blood leukocytes in chronic myelocytic leukemia according to the grade of their maturity by density gradient centrifugation].

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Cell Separation↗

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[Use of gelatin sedimentation method for the isolation of mono- and polynuclear leukocytes from normal human peripheral blood].

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Blood Sedimentation↗

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[Differential inhibition of synthesis and methylation of DNA fragments by hydroxyurea in L5178Y lymphoblasts in vitro].

In cultures of mouse L5178Y lymphoblasts treated with low concentrations of hydroxyurea during the logarithmic phase of growth differential inhibition of synthesis and methylation of various DNA fragments was observed. Some evidence is presented that the effect may be due to different sensitivity of cells to the action of hydroxyurea at various times of the S-phase.

Animals↗