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Biomedical subjects

J Maeda

Publications and source records attributed to J Maeda.

At least 109 records · Page 6Linked to original sources
PubMed1986

[Adenocarcinoma arising in congenital dilatation of the intrahepatic bile duct].

A multilocular lesion was found in the left lobe of the liver in a 70-year-old woman who had complained of jaundice, fever and tumor of epigastrium. There was a continuous and branching cystic lesion in the resected left lobe of the liver diffusely, and communication with the right hepatic duct and the extrahepatic duct was recognized. These cystic spaces were filled with bile and mucus. The inside of the wall was covered with columnar epithelium showing papillay proliferation with marked mucin production. Furthermore, adenocarcinoma was demonstrated in multifoci surrounded by hyperplastic and dysplastic epithelium. This case was diagnosed as congenital dilatation of the intrahepatic bile duct accompanying adenocarcinoma.

Adenocarcinoma↗
PubMed1985

[Time-dependent measurement of differential digital plethysmogram in bicycle ergometer exercise].

Time-dependent measurements of differential digital plethysmogram during exercise were made on five male subjects. The results obtained were as follows; Differential digital plethysmogram (delta DPG) was obtained by using biophysical amplifier with the time constant of 0.03 seconds which minimized the fluctuation of the baseline in digital plethysmogram (DPG). A linear relationship was shown in P wave amplitude of both delta DPG and DPG. The decrease in delta DPG-P waves was observed in visual concentrations, mental learning and arithmetic, initial inspiratory phase with tachycardia, maximal inspiratory and/or expiratory breath holding, and head-up tilt at 60 degrees or over. The increase in delta DPG-P waves was obtained at the expiratory phase with bradycardia and in the effect of alcohol intake. During 15 minutes of bicycle ergometer exercise at 750 kpm/min, the P wave amplitude in delta DPG decreased to 77% of the control in the first one minute of exercise, and then gradually increased to 218% at the final stage of exercise (p less than 0.01). Heart rate measured simultaneously increased, as compared from the beginning of exercise. P wave amplitude and heart rate after exercise decreased progressively to the control level. It is suggested that the initial decrease in P wave amplitude of delta DPG couples with the dominant activity of the sympathetic vasoconstrictor, and the final increase in P waves is due to the compound factors of the increased cardiac output and arteriolar vasodilation.

Adult↗
PubMed1984

Reorganization of corticorubral synapses following cross-innervation of flexor and extensor nerves of adult cat: a quantitative electron microscopic study.

A quantitative electron microscopic study of corticorubral synapses was performed in the red nucleus (RN) of adult cats to determine the morphological correlates for the changes in time course of corticorubral excitatory post-synaptic potentials, which occur following cross-innervation of forelimb extensor and flexor nerves. Corticorubral synaptic endings were identified by anterograde degeneration after lesions of the ipsilateral sensorimotor cortex. Rubrospinal neurons innervating upper spinal segments were electrophysiologically identified and filled with horseradish peroxidase (HRP). These cells were mainly situated in the dorsomedial part of RN. Electron micrographs of the degenerating corticorubral synaptic endings were taken in the region surrounding HRP-filled neurons and the diameter of the dendrites contacted by such terminals was measured. In the cross-innervated animals many degenerating terminals were found to synapse on dendrites with large diameter and the somata of neurons in RN. This is in contrast to the previous observations in normal cats, in which very few corticorubral synapses were found to synapse on proximal dendrites and somata of RN neurons. The diameter of HRP-filled neurons in cats which were cross-innervated was slightly smaller than those observed in normal animals. These results indicate that new corticorubral synapses were formed on proximal dendrites and somata of RN neurons as a consequence of cross-innervation.

Animals↗
PubMed1984

Monoclonal IgM-secreting neoplasms. Clinical and morphologic heterogeneity.

Two patients with monoclonal IgM-secreting neoplasms are presented. Though both patients could be diagnosed as Waldenström's macroglobulinemia, the clinicopathologic features were quite contrastive. Most neoplastic cells in Case 1 showed lymphocytic morphology with rather leukemic process, while those in Case 2 were highly polymorphic with solid proliferation. The clinical and morphologic heterogeneity in these cases and cases in the literature is discussed, and the possible requirement to establish a system for the subclassification of IgM-secreting neoplasms is insisted.

Antibodies, Monoclonal↗
PubMed1984

Physiological identification of midbrain neurons related to lens accommodation in cats.

Single units were sought in the medial midbrain, whereas lens accommodation of the eye was monitored by using an infrared high-speed optometer. Nineteen of 135 units isolated were identified as accommodation-related units by two criteria: 1) they discharged in synchrony with spontaneously occurring accommodation, and b) the units were driven by stimulating the interpositus nucleus of the cerebellum. In eight other experiments, units were sought that were antidromically activated by stimulating parasympathetic preganglionic fibers to the ciliary ganglion. Eleven of 46 antidromically activated units were identified as accommodation-related units (accommodation-related oculomotor units). Accommodation-related oculomotor units were found in the medial midbrain within 1 mm of the midline. The majority of them were located lateral and dorsal to the Edinger-Westphal nucleus.

Accommodation, Ocular↗
PubMed1984

[Nutritional support in surgery: with special reference to fat emulsion and carnitine].

Energy metabolism of fat emulsion has been studied in rats with various conditions including postoperative catabolism, chronic and acute hepatic dysfunction, diabetes and sepsis. The results indicate that fat emulsion is rapidly eliminated from the blood stream and metabolized readily even in such conditions. Based on these findings, we have actively employed fat emulsion clinically as energy source. In septic rats, it was demonstrated that levels of carnitine decreased and that this decrease was based upon a decrease of synthesis. When carnitine was administrated together with fat emulsion, the energy metabolism returned to approximately normal level. This report also describes the tissue concentrations of carnitine in diabetic rats and the blood and urine concentrations of carnitine in postoperative patients.

Animals↗