Search PubMed⌕ Search

Biomedical subjects

J M Pierce

Publications and source records attributed to J M Pierce.

At least 55 records · Page 3Linked to original sources
PubMed1980

Renal cystography: unusual complication.

A patient is described in whom renal cyst aspiration and subsequent contrast material instillation caused pain, flank mass and spiking temperature, evantually necessitating exploration and drainage of a sterile abscess. Undiluted, hyperosmotic contrast material was the probable cause of this complication. A simple, easy way to calculate cyst volume and amount of contrast material to be used during cyst aspiration injection studies is discussed.

Contrast Media↗
PubMed1980

Genital ulceration due to Stoddard solvent.

Five cases of ulcerative and erythematous lesions on the genitals and buttocks which occurred among workers whose coveralls had been dry-cleaned using Stoddard solvent are presented. A typical clinical picture and investigative results were consistent with irritant contact dermatitis. The literature on the two most commonly used dry-cleaning fluids is reviewed. The hazards of dry-cleaning chemicals, both for workers in dry-cleaning shops and for their clients who wear the cleaned clothes, are outlined. Suggestions pertaining to the avoidance of cutaneous reactions are detailed.

Adult↗
PubMed1980

Biological effects of short course radiation in transitional cell carcinoma of the bladder.

We evaluated the biologic effects of short course radiation therapy (1800 to 2000 rads) administered before cystectomy by placing tumors in tissue culture and observing their growth. No differences in growth were observed between irradiated and nonirradiated tumors. The minimal sublethal dose of radiation that effectively suppresses the growth of transitional cell carcinoma needs to be determined.

Carcinoma, Transitional Cell↗
PubMed1979

Vasovasostomy: evaluation of four surgical techniques.

Four techniques of vasovasostomy were evaluated in two groups of twelve dogs each. In group 1, one side was anastomosed by a standard technique over a Silastic stent and the other side was anastomosed using a two-layer microsurgical technique. In group 2, one side was anastomosed by a standard technique without a stent and the other side was anastomosed using a one-layer microsurgical technique. Patency was evaluated by methylene blue injection distal to the anastomosis and was found to be about the same for all three groups in which anastomosis was performed without stents. The stented group had a high rate of obstruction. Histologic evaluation, however, showed superiority of both microsurgical techniques over each of the stnadard procedures.

Animals↗
PubMed1979

Reliability of bone marrow acid phosphatase as a parameter of metastatic prostatic cancer.

The reliability of bone marrow acid phosphatase determination by a spectrophotometric assay and 2 immunochemical methods was evaluated in 40 patients: 20 men with known prostatic carcinoma and 20 men of comparable age without clinical evidence of prostatic cancer. The large percentage of falsely positive results obtained by the colorimetric assay invalidates this method as the sole parameter of metastatic prostatic carcinoma.

Acid Phosphatase↗
PubMed1979

Urological injuries associated with pelvic trauma.

We reviewed 100 consecutive cases of pelvic fractures at our hospital to establish the relationship between bone injuries and urological lesions. There were 11 major urological injuries found: 6 patients had bladder laceration, 4 had rupture of the membranous urethra and 1 had a ureteral injury. Emphasis is placed on the physiopathology of the urological injuries.

Adolescent↗
PubMed1979

Posterior urethral stricture repair.

Experience with 54 operations for the membranous-prostatic urethral stricture is presented. There were 7 operations performed through pubectomy exposure, 6 Badenoch operations, 31 exteriorization 2-stage operations using a perineal-scrotal flap for the first stage and 10, 1-stage transperineal end-to-end anastomoses after scar tissue had been excised. The technique for the transperineal approach is presented. Presently, a 1-stage end-to-end anastomosis of the bu.ferred. Exteriorization urethroplasty using the perineal-scrotal flap is recommended when an end-to-end anastomosis is not feasible, either because of a long stricture or severe scar secondary to previous operative failures. The pubectomy approach is seldom needed but the Waterhouse pubectomy procedure is recommended as a possibility in patients who cannot be placed in the exaggerated lithotomy position.

Child↗
PubMed1979

Immunochemical identification of prostatic epithelial cells in culture.

An indirect immunofluorescence technique for identifying prostatic acid phosphatase was used to evaluate primary prostatic cell cultures and established cell lines of prostatic origin. With the use of this technique, we positively identified acid phosphatase immunochemically of prostatic origin in cell lines EB 33 and MA 160. Other cell lines showing positive immunofluorescence reactions include H 494, H 575, and DU 145.

Acid Phosphatase↗
PubMed1978

Controlled trial prednisolone in acute polyneuropathy.

In a multicentre, randomised trial of prednisolone in acute polyneuropathy of undetermined aetiology (Guillain-Barré syndrome), 21 patients were treated with prednisolone (60 mg daily for one week, 40 mg daily for four days, and then 30 mg daily for three days) and 19 did not have steroid treatment. Patients were graded on a six-point scale by one of two neurologists who had no knowledge of the treatment schedule. Reassessment at one, three, and twelve months consistently showed greater improvement in the control than the prednisolone group but the only statistically significant result was in the improvement at three months among patients entered to the trial within a week of onset of illness. The 6 control patients had improved by 2.5 +/- 0.43 grades by three months from entry to the trial whereas the 10 prednisolone patients had only improved by 0.9 +/- 0.46 grades (P less than 0.05). There was 1 death related to the polyneuropathy in each group, and 1 suicide in a control patient during convalescence. 6 prednisolone patients were left with considerable disability compared with 1 control patient. There were 3 relapses in the prednisolone group, but none in the control group. The results indicate that steroid treatment is not beneficial and can be detrimental in acute neuropathy of undetermined aetiology.

Acute Disease↗
PubMed1978

Bone marrow acid phosphatase in staging of prostatic cancer: how reliable is it?

To evaluate the reliability of bone marrow acid phosphatase in the staging of prostatic carcinoma we analyzed 50 bone marrow samples collected at random from the hematology service at this hospital. The samples were assayed for acid phosphatase content by a colorimetric method using sodium thymolphthalein monophosphate as a substrate and by 2 immunochemical assays developed at our laboratory (counter immunoelectrophoresis and radioimmunoassay). We found a high percentage (61 per cent) of falsely positive results in patients with various hematological diseases without evidence of prostatic carcinoma by the colorimetric evaluation. All of these patients except 1 had negative immunochemical assay. Until a specific assay for prostatic acid phosphatase is developed for clinical use we caution the use of a single elevation of bone marrow acid phosphatase as a parameter of metastatic disease.

Acid Phosphatase↗
PubMed1978

The effects of topical instillation of adriamycin in bladder tumors of rats fed with FANFT.

Topical bladder instillation of adriamycin was evaluated in FANET produced rat tumors produced by diets containing (N-[4-(5-Nitro-2-Furyl)-2-Thiazolyl] Formamide). The drug was ineffective in either preventing or eradicating tumors. The failure of response in this animal model may be related to drug schedule, biological potential of this tumor, or ineffectiveness of Adriamycin in this tumor.

Administration, Topical↗
PubMed1978

Posterior urethral stricture repair.

Experience with 54 operations for the membranous-prostatic urethral stricture is presented. There were 7 operations performed through pubectomy exposure, 6 Badenoch operations, 31 exteriorization 2-stage operations using a perineal-scrotal flap for the first state and 10, 1-stage transperineal end-to-end anastomoses after scar tissue had been excised. The technique for the transperineal approach is presented. Presently, a 1-stage end-to-end anastomosis of the bulbomembranous urethra to the prostatic urethra through a perineal approach is preferred. Exteriorization urethroplasty using the perineal-scrotal flap is recommended when an end-to-end anastomosis is not feasible, either because of a long stricture or severe scar secondary to previous operative failures. The pubectomy approach is seldom needed but the Waterhouse pubectomy procedure is recommended as a possibility in patients who cannot be placed in the exaggerated lithotomy position.

Child↗
PubMed1977

Surgical management of major renal trauma: a review of 102 cases treated by conservative surgery.

A review is presented of 102 patients with significant renal trauma seen in the last 5 years. All patients underwent exploratory laparotomy for abdominal trauma and had associated urologic injuries, which were managed by conservative surgery. Forty-eight patients had non-expanding retroperitoneal hematoma and were treated expectantly. Nine patients needed exploration and drainage only, while 18 had some form of renorrhaphy. Four patients underwent repairs of renal pelvic injuries, 12 underwent partial nephrectomy and 11 underwent repairs of renal pedicle injuries. A conservative approach to renal trauma is emphasized.

Abdominal Injuries↗
PubMed1977

Gunshot wounds of the ureter: 5 years of experience.

During 5 consecutive years 20 patients with ureteral gunshot wounds were treated at the Detroit General Hospital. Among the 19 patients treated surgically 4 unrelated deaths occurred and 3 patients underwent a second exploration. No kidney was lost. Our surgical technique involving a tension-free, watertight anastomosis and diversion is emphasized. We believe that better results are obtained with stented repairs.

Adolescent↗
PubMed1977

Topical instillation of doxorubicin hydrochloride in the treatment of recurring superficial transitional cell carcinoma of the bladder.

Thirteen patients with recurring stage A transitional cell carcinoma of the bladder were treated with monthly bladder instillations of doxorubicin hydrochloride. Follow-up at 3-month intervals has shown excellent control of tumor recurrence with complete remissions for up to 21 months in 2 patients. The median for remission in 8 of 13 patients has been 10 months. Two patients with bladder papillomatosis were treated successfully by the same method.

Administration, Topical↗