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Biomedical subjects

J M Pierce

Publications and source records attributed to J M Pierce.

At least 37 records · Page 2Linked to original sources
PubMed1986

Myocardial infarction and its influence on male sexual function.

Sexual dysfunction was studied in 50 patients who had had a myocardial infarction (MI) matched with 50 control patients who were comparable in terms of age, hypertension, diabetes, and smoking. The MI group revealed sexual dysfunction in 76%, with erectile dysfunction in 42%. In the control group there was sexual dysfunction in 68% and erectile dysfunction in 48%. There was no statistically significant difference observed between the two groups. However, there was a significant influence of sex counseling on subsequent sexual functioning. Patients who received information as to when it was safe for them to resume sexual activity showed a lesser degree of apprehension in the post-MI period. The need of sexual rehabilitation for these patients and more thorough epidemiological comparative studies are suggested.

Adult↗
PubMed1985

The effects of cyclophosphamide, ketoconazole, aclacinomycin-A, methotrexate, and scheduled methotrexate-5-fluorouracil combination chemotherapy on the transplantable R-3327 prostatic adenocarcinoma in the F1 hybrid male rat.

Male F1 hybrid rats bearing the R-3327 transplantable prostatic adenocarcinoma demonstrating similar growth patterns within the original sample of animals were carefully separated into control and treatment groups. This assured treatment of tumors with similar cell kinetics within each group. In the first study, two separate drug protocols were investigated by intraperitoneal injection, namely cyclophosphamide (100 mg/kg) once every 4 weeks for 8 weeks and scheduled methotrexate (7.5 mg/kg) followed in 90 minutes by 5-fluorouracil (50 mg/kg) once each week for 8 weeks. Excellent suppression of tumor growth was obtained with each treatment protocol. Both were significant at the 0.01 level. In the second study, methotrexate (100 mg/kg) intraperitoneally once each week for 6 weeks, aclacinomycin-A intraperitoneally once each week for 4 weeks, and ketoconazole (60 mg/kg) via gavage 5 times a week for 6 weeks were administered to the animals in each respective group. Aclacinomycin-A and ketoconazole showed significant suppression of tumor growth at the 0.01 and 0.05 levels, respectively. Methotrexate suppressed tumor growth, but did not reach levels of significance over the duration of the study (0.2 less than P less than 0.3).

Aclarubicin↗
PubMed1984

Characterization of a transitional cell carcinoma line arising from a previously irradiated tumor.

A cell line derived from a poorly differentiated transitional cell carcinoma of the bladder in a patient previously treated with external beam radiation has been established. The line has stable hyperdiploid karyotype which is distinct from other established transitional cell carcinoma lines. Injection of the cells into nude mice induces tumor with histological characteristics similar to the original tumor. This line may serve as a model to study mechanisms of radioresistance in transitional cell carcinoma of the urinary bladder.

Aged↗
PubMed1983

Clinical and serologic study of Sjögren's syndrome in patients with progressive systemic sclerosis.

Fifty-eight patients with progressive systemic sclerosis (PSS) were evaluated clinically and by biopsy of the minor salivary glands of the lips for the presence of Sjögren's syndrome. Clinical findings included dry eyes in 38%, dry mouth in 32%, parotid enlargement in 4%, and an abnormal Schirmer's test in 34%. Histologic changes in lip biopsies included lymphocytic infiltrates characteristic of Sjögren's syndrome in 17 individuals (29%). In 19 (33%) there was periglandular and intraglandular fibrosis (PSS-fibrosis) without significant inflammation, an alteration characteristic of PSS per se. In the remaining 22 patients (38%) with PSS, no abnormality was found. Of those with PSS and Sjögren's syndrome, 53% had serum antibodies to SS-A and/or SS-B, while only 1 patient with a normal biopsy had either of these antibodies. Anti-SS-A and anti-SS-B were not detected in patients with glandular fibrosis alone. The mortality rate of the PSS-fibrosis group was higher due to a variety of severe internal manifestations related to PSS. Antibodies to SS-A and SS-B are useful serologic markers of the presence of Sjögren's syndrome in patients with PSS.

Adolescent↗
PubMed1983

Penile calibration for nocturnal penile tumescence studies.

Artificial penile erections were created in 23 impotent patients by infusion of heparinized saline solution into the corpora cavernosa. Penile circumference as related to rigidity was accurately assessed. The increase in circumference necessary to produce erection adequate for vaginal penetration varied from 7.5 to 35 mm, whereas for maximum rigidity the penile circumference increase varied between 10 mm and 40 mm. These were then compared with the changes during nocturnal penile tumescence studies. Even though 5 patients in the series had erection greater than 15 mm, 40 per cent of them did not achieve rigidity adequate for vaginal penetration. One patient had nocturnal tumescence of only 12 mm; this, however, was an erection adequate for vaginal penetration. The approach discussed in this article may allow the rational use of portable home tumescence monitoring.

Adult↗
PubMed1982

Ophthalmia neonatorum in the 1980s: incidence, aetiology and treatment.

In a survey of 450 consecutive births in Southampton a 12% incidence has been found of ophthalmia neonatorum. Bacterial pathogens were isolated from only one-third of the cases, while nonpathogens were isolated from as many cases as controls. There was an incidence of chlamydial infection of 3.7 per 1000 live births, while Neisseria gonorrhoeae could not be found. Chloramphenicol is recommended for topical antibacterial treatment, but chlamydial infection will not respond; it must be considered in 'resistant' cases, when both the neonate and the parents will need treatment with erythromycin or tetracycline.

Anti-Bacterial Agents↗
PubMed1981

Lymphatic complications in renal allografts--a new look.

The pathophysiology of lymphatic complications was evaluated in 10 patients as to the possible source of lymphatic fluid. Both the recipient's peripheral lymphatics and the allograft's lymphatics were found to contribute to lymphatic complications. The prevention of lymphoceles and lymphatic fistulas may be accomplished by careful ligation of both the recipient's and the allograft's lymphatics.

Fistula↗
PubMed1981

Microsurgical vasovasostomy: immunologic consequences and subsequent fertility.

Fifty-five men have undergone microsurgical vasovasostomy with at least a 1-year follow-up. Serum samples from these men were obtained in the preoperative and postoperative periods, and titers of agglutinating and immobilizing antibodies were measured and evaluated in relationship to subsequent fertility. Of the 35 patients in whom adequate serum and semen samples were obtained over a period of 1 year, 17 men proved their fertility and 18 patients in the allotted time span had not yet fathered any children. No statistically significant difference in the level of antibody titers could be found between the fertile group and the infertile group. Seminal antibody titers were determined in 25 men. Five of these men have thus for impregnated their wives. Only a small number of men were found to have positive titers for agglutinating and/or immobilizing antibodies in their semen. The presence or absence of spermagglutinating and/or sperm-immobilizing antibodies in the sera of men who have undergone vasectomy reversal does not seem to interfere with subsequent fertility.

Antibodies↗
PubMed1981

Immunofluorescence for prostatic acid phosphatase: clinical applications.

An indirect immunofluorescence technique to detect cells producing prostatic acid phosphatase was used to evaluate 12 biopsies of soft tissue masses of possible metastatic prostatic carcinoma. In 10 patients varying degrees of immunofluorescence were observed, confirming the origin of the primary tumor. Specimens from 34 patients with prostatic carcinoma were obtained either by radical prostatectomy or transurethral resection of the prostate. A comparison of histological grade (Gleason), semiquantitative immunofluorescence for prostatic acid phosphatase and hormonal responsiveness was done. There was a suggestion of higher hormonal responsiveness in the group with a low Gleason score and a high percentage of positive immunofluorescence that presently cannot be evaluated completely since some patients still are under therapy. This method may be used in the future in conjunction with other techniques, such as androgen receptors, to define a population of patients most likely to respond to hormonal manipulation.

Acid Phosphatase↗
PubMed1981

Clinical evaluation of immunological methods for detection for serum prostatic acid phosphatase.

Evaluation of serum acid phosphatase by 3 immunochemical methods (radioimmunoassay, counterimmunoelectrophoresis and immunoenzymoassay) was done in 3 groups of patients. In 42 patients wit stage D prostatic carcinoma a comparison of serum acid phosphatase determination by colorimetric assay and the 3 immunochemical methods in samples obtained before and after initiation of therapy showed an excellent correlation among the assays. Presently, we see no advantage of the immunochemical methods over the colorimetric assay in this group of patients. Among 100 patients studied in a blind fashion to detect those with unsuspected prostatic carcinoma no such cases were found. In the last group of patients with localized prostatic carcinoma staged surgically by pelvic lymphadenectomy the only elevations of serum acid phosphatase were observed in patients with extraprostatic involvement.

Acid Phosphatase↗
PubMed1981

Changing surgical concepts in the treatment of priapism.

The treatment of priapism has changed significantly because of better understanding of the physiology of erection and of the pathophysiology of the disease. Several operative procedures have been advised to provide better venous drainage to the corpora. Herein we describe our experience with 20 patients. In 7 cases a modification of the cavernospongiosum shunt was used. This shunt is done under direct vision at the level of the proximal glans, thus, providing a better cavernosum-spongiosum shunt.

Adolescent↗
PubMed1981

Urethroplasty.

Explore the source record for details and available documents.

Female↗
PubMed1980

Idiopathic rupture of bladder.

Idiopathic bladder rupture is uncommon but not rare. It should be considered in patients with depressed sensorium who present with mild azotemia, acidosis, and inability to void. A cystogram is diagnostic, and recovery is usually uneventful after primary bladder closure.

Alcoholism↗