The authors report the case of a 51-year-old woman who developed cholestatic and cytolytic hepatitis after an overdose of sodium aurothiopropanol sulfonate 1.1 g, namely 300 mg gold metal. Liver biopsy demonstrated cholestasis, centrolobular steatosis and portal fibrosis. Electron microscopy showed abundant lipo-pigments in the hepatic and cellular cells, as well as myelinic bodies. Gold analysis by atomic absorption spectroscopy showed a level of 22.76 micrograms per ml in the plasma and a level of 2.16 micrograms per g in the liver. Chelating agents increased the urinary gold excretion, but were without effect on the course of hepatitis. Dimercaptopropanol seemed to favor the occurrence of other gold salt side-effects and penicillamine increased the hepatic cytolysis. The patient recovered without sequelae.

Anti-Inflammatory Agents↗

PubMedDate not supplied

[Usefulness of micro-organism counts in positive haemocultures (author's transl)].

In patients with positive haemoculture counting the number of micro-organisms per ml of blood can be of interest for both diagnosis and prognosis. Contamination is practically excluded when values exceed 20 organisms/ml, and bacteraemia when they exceed 500 organisms/ml. Generally, the higher the count the greater the likelihood of septicaemia. Values lower than 2 organisms/ml correspond in most cases to Gram-negative infections. Excluding the latter, which carry a high lethal risk, the mortality rate in septicaemia increases with the number of micro-organisms in the blood.

Bacteriological Techniques↗

PubMedDate not supplied

[The immuno-allergic accidents induced by treatment with a venotropic agent containing catechines. Report of three cases (author's transl)].

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Adult↗

PubMedDate not supplied

[A mood of urgency facing drug dependence].

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Drug Overdose↗