The authors carried out long-term clinical and E.E.G. studies on 100 cases of acute drug poisoning. They made the following conclusions: - in unexplained coma, the E.E.G. can indicate toxic aetiology and may sometimes even suggest which drug is responsible, especially for certain chemical groups (barbiturates, phenothiasines, benzodiazepines); - the E.E.G. picture contributes a valuable indication of the depth of coma; the way in which it evolves affects the prognosis; - the effectiveness of therapy may be judged by monitoring cerebral electrical activity.

Acute Disease↗

PubMedDate not supplied

[Joseph-Alexis Stoltz (1803-1896), dean of the two Faculties].

Life and works of Joseph-Alexis Stoltz, gynecologist and obstetrician Professor at the Strasbourg Ecole de Medecine, then dean in the same town Faculte de Medecine (1867-1872) and after in Nancy (1872-1879). With Adolphe Wurtz, dean of Paris Faculte de Medecine, Edmond Simonin, director of Nancy Ecole de Medecine, and Jules Simon, Minister of the Instruction Publique he brought to a successful conclusion, in 1872, the transfer of the Faculte de Medecine from Strasbourg to Nancy

Faculty, Medical↗

PubMedDate not supplied

[Acute verapamil poisoning. 6 cases. Review of the literature].

Six cases of acute verapamil poisoning are reported. The dose ingested ranged between 1.2 and 9.6 g. In all cases other drugs had also been ingested and especially betablockers in two cases. Symptomatology included a cardiogenic shock in two cases and an atrioventricular block in four cases. A hemodynamic study in one case showed a cardiogenic shock with increased systemic vascular resistances. The treatment of cardiogenic shock included artificial ventilation, several vasopressors and inotropic agents and cardiac pacing in one case. All patients recovered without sequelae. A toxicokinetic study performed in two cases showed plasma half lives of 7.9 and 13.2 hours, total body clearances of 425 and 298 ml/min. Only 2 to 4.2 per cent of the dose ingested were eliminated in urine. These results confirm the severity of verapamil overdose and the efficacy of symptomatic treatment by inotropic agents. The high rate of spontaneous elimination by hepatic metabolism does not justify drug removal by extra-corporeal methods.

Acute Disease↗

PubMedDate not supplied

[Acute arsenical peripheral neuropathy].

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Acute Disease↗