Biomedical subjects
Publications and source records attributed to J M Levy.
A technique is presented to eliminate the residual gradient more completely after removing the main pulmonary band at the time of primary repair of ventricular septal defect. The band and underlying pulmonary artery are circumferentially excised, except for a small posterior part, and pulmonary artery is reanastomosed.
From 1971 to 1975, 17 consecutive patients aged 1 day to 4 years underwent Blalock-Taussig shunts for severe tetralogy of Fallot. Three infants were under 6 weeks of age and 7 (41%) under 1 year. There were no hospital deaths. Modification of the shunt technique adapts it to any size infant. The subclavian artery is divided at its major branches and the end spatulated to enlarge it. The artery is occluded while the shunt is constructed. No intraoperative complications were encountered; all patients have a shunt murmur with no early or late closure. No child has had heart failure or hypoxic spells. Flows measured at operation equaled one-quarter to one-half of the child's normal cardiac output. Ligation of the shunt at subsequent repair is uncomplicated. One child died three years later at correction from causes unrelated to the shunt. With appropriate modifications in technique, the Blalock-Taussig shunt is the operation of choice, at any age, for palliation of severe tetralogy of Fallot.
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In vitro analysis of the mitosis from 3-day lymphocyte cultures from two normal males and two normal females treated with bromodeoxyuridine and stained with acridine orange after addition of vincristine during different times demonstrated that vincristine inhibits the progression of the second division. When the second division progressed, the number of sister chromatid exchanges was significantly decreased. Vincristine could act by inhibiting the copying of DNA. A dosage effect is demonstrated when vincristine is added to the cultures during the first 24 hr.
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The relationship between expectation and subjective outcome in childbirth was investigated. Sixty primigravidae responded to a questionnaire before and after labor and delivery. The evaluation of childbirth as favorable or unfavorable was related to whether the experience was rated better or worse than expectation. Anticipation of labor and delivery was positively related to a woman's perception of her mother's experience in childbirth, but was not related to the woman's evaluation of her actual delivery experience. Women receiving extreme communications or no information from their mother reported poorer outcomes than women who received moderate communications. Anxiety, as measured by the Taylor Manifest Anxiety Scale, and denial, as measured by the Self-Criticism Scale of the Tennessee Self-Concept Scale, were not related to anticipation or subjective outcome measures. Results were interpreted within Janis's theory of psychological stress.
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