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Biomedical subjects

J M Edwards

Publications and source records attributed to J M Edwards.

At least 163 records · Page 9Linked to original sources
PubMed1972

Detection of Bordetella pertussis antibodies in human sera by complement-fixation and immunofluorescence.

The complement-fixation test, as commonly used in the diagnosis of viral infections, was studied for its possible application to the diagnosis of whooping cough and the detection of antibody following pertussis vaccination. The results were compared with those obtained in parallel immunofluorescence tests. CFTs were performed on sera from 41 patients with whooping cough (Bordetella pertussis isolated), 125 vaccinated persons, and 618 controls; parallel tests by IF were made on sera from 24 cases of whooping cough, 36 vaccinated persons and 37 controls. Results of both tests correlated closely and showed that titres of diagnostic significance were seldom found in control sera. They also showed that, in patients suffering from whooping cough, antibody in a single specimen or a rise in antibody between paired sera was almost always demonstrated. Titres in general were lower in infants less than 6 months of age. IgG antibodies were involved in both tests. Although the number of sera tested was small both tests appear to be reliable as means of demonstrating the presence of antibody formed during the course of infection and after vaccination.

Adolescent↗
PubMed1969

Lymphovenous shunts in man.

Lymphovenous shunts have been detected in patients by lymphography with Ultrafluid Lipiodol. No shunts were found in patients with normal lymphatic systems. They were found in patients with lymphoedema, with lymph nodes involved by malignant disease, and in patients who had had surgical interruption of lymphatic pathways, either vessels or nodes. The total incidence of lymphovenous shunts in 700 lymphographic studies was 2.3%. The incidence in the various pathological groups was highest in those with obvious lymph node involvement.In certain situations, particularly primary lymphoedema, the role of a lymphovenous shunt appears favourable to prognosis. In other situations a deleterious effect may be produced.

Adult↗