A total of 644 umbilical cords were examined over a period of 5 years, 40 cords (6.2 per cent) showed more than the normal three vascular profiles on cross-section. Both the umbilical arteries and vein showed multiple profiles, although arterial profiles were far more commonly multiple. Clinical data were correlated with the histological findings. Heavy smoking was significantly associated with multiple vascular profiles. Maternal age and rhesus group were not significantly related however, but there was some association with primiparity. Fetuses with a gestational age between 33 and 38 weeks were significantly more likely to have multiple vessels than either fetuses beyond 38 weeks or less than 33 weeks gestation. Multiple channels also occurred significantly more frequently in still birth than in live birth cords. We suggest that multiple vascular profiles represent a response to intrauterine hypoxia. Inflammation of the cord was associated with multiple channels and suggests linkage between these two indications of fetal distress.

Female↗

PubMedDate not supplied

Antineoplastic activity and cytotoxicity of flavones, isoflavones, and flavanones.

Several hundred flavonoid derivatives, natural and synthetic, which have been tested in the screening program of the National Cancer Institute, have been examined for indications of structure-activity relationships which might exist among these compounds. No such relationships are apparent. In spite of occasional activity these compounds do not warrant further detailed pursuit as anti-tumor agents.

Animals↗

PubMedDate not supplied

Cytotoxic principles from the sap of Kalmia latifolia.

Examination of the sap of Kalmia latifolia has revealed Grayanotoxin I (1), phloretin (3), and 2',6'-dihydroxy-4-methoxyacetophenone (5) as cytotoxic components. Twenty-one dihydrochalcones have been synthesized and tested for cytotoxic activity. 2'3,3'4,4'-Pentahydroxydihydrochalcone (8) has been found to be cytotoxic and to have marginal activity in vivo. Seven new dihydrochalcones are described.

Animals↗

PubMedDate not supplied

Chloroquine dissociation of antigen-antibody complexes. A new technique for typing red blood cells with a positive direct antiglobulin test.

We have investigated a method using the quinoline derivative chloroquine diphosphate (200 mg/ml, pH 5.0) to dissociate antibody without denaturing red blood cell antigens. All samples treated with chloroquine diphosphate demonstrated some dissociation of the coating immunoglobulin, and in most cases, the ability to dissociate the coating immunoglobulin was related to the strength of the direct antiglobulin test (DAT). Complete dissociation of antibody was observed in 22 of 40 strongly in vitro sensitized samples and 47 of 56 in vivo sensitized specimens, with no apparent loss of ABH, Rh, MNSs, P1, Lewis, Kell, Duffy, or Kidd antigens. We have found the chloroquine dissociation technique to be of value in the examination of red blood cells with a positive DAT, either for the qualitative or quantitative expression of antigens.

ABO Blood-Group System↗

PubMedDate not supplied

Use of rabbit red cells for adsorption of cold autoagglutinins.

This study investigated the use of formaldehyde-fixed rabbit red cells and rabbit red cell stroma for the adsorption of cold autoagglutinins. Both methods were equally effective and removed all antibody activity at room temperature in 92 percent of the samples. However, some alloantibodies such as anti-D, -E, and -Leb were also reduced in titer or completely absorbed.

Absorption↗

PubMedDate not supplied

Nursing care of a patient with chronic abdominal pain secondary to porphyria: a case study.

Patients with porphyria present a wide variety of challenges to healthcare providers. The nursing care required by patients with porphyria is similar to that needed by patients suffering from chronic illnesses. This nursing care includes pain management, management of nutrition, an appropriate bowel regimen, the recognition of possible complex neurological manifestations, and psychosocial support (Shively et al., 1994). A thorough understanding of the disease process is essential to accurately assess the patient and develop an effective plan of care.

Abdominal Pain↗

PubMedDate not supplied

Treatment of melanoma by endolymphatic therapy.

Explore the source record for details and available documents.

Humans↗

PubMedDate not supplied

Lymphography in congenital mixed vascular deformities of the lower extremities.

Explore the source record for details and available documents.

Arteriovenous Malformations↗