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Biomedical subjects

J M Caille

Publications and source records attributed to J M Caille.

At least 37 records · Page 2Linked to original sources
PubMed1988

CT-diskography in the evaluation of the postoperative lumbar spine. Preliminary results.

Thirty-three patients with recurrent sciatica after lumbar-disk surgery were studied for recurrent herniated nucleus pulposus (HNP) by CT alone and CT-diskography (CTD). Twenty-six patients underwent surgical reexploration allowing correlation with CTD. CTD made a correct diagnosis of recurrent HNP in twenty-one patients showing an extravasation of the contrast medium from the disk space into the medullary canal. In two cases CTD was positive for recurrent HNP but surgery showed only fibrosis. The amount of contrast leak was very small in these two cases along the posterior common longitudinal ligament, and the junction with the disk was very narrow. Because of their clinical presentation three patients with negative studies were operated upon. One showed only fibrosis and the two others showed an associated disk fragment. Among the twenty-one true-positive cases, seven showed a combination of recurrent HNP and scarring. Contamination of CSF by the contrast medium through the dura was observed in two patients. Although a prospective comparative study between CTD and IV-contrast-enhanced CT is necessary, CTD appears to be a useful diagnostic procedure for recurrent HNP after surgery of the lumbar spine.

Adult↗
PubMed1988

[MRI and surgery of epilepsy].

The evaluation of M.R.I. in the presurgical management of epilepsies requires establishing the significance of the abnormal signals. In 15 cases, correlations among M.R.I., electrophysiological data obtained by chronic intracerebral recordings and histological examination were studied. Abnormalities were detected by M.R.I. in 12 cases (80%). An accurate epileptic-focus topographical orientation was obtained by M.R.I. in 10 cases. But M.R.I. findings did not coincide with functional data obtained by S.E.E.G. recordings. Abnormalities detected by M.R.I. led to rectify the previous hypothesis about the epileptic focus localization in two cases. One false positive and one case of incomplete data would have been misleading if S.E.E.G. had not been performed. M.R.I. abnormalities included two morphological changes and ten high intensity T2 signals. The increased T2 intensity was more often focal (9) than diffuse (1). Among the 8 cases of increased T2 intensity correlated to the epileptic focus, 1 was histologically normal, 3 corresponded to specific lesions (astrocytoma: 1, hamartoma: 2) and 4 corresponded to non specific lesions (gliosis: 2, spongiosis: 2). When M.R.I. was normal at the site of the epileptic focus, either no alteration (2) or non specific lesions (2) were found. Uncus herniation could not be identified with M.R.I. M.R.I. has proven sensitive, detecting small epileptogenic lesions missed by C.T. Moreover in some cases, high T2 signals have been correlated topographically with the epileptic focus and histologically with non specific lesions. These signals are more likely related to a functional phenomenon such as an increase in water content than to the histopathological findings themselves.

Adolescent↗
PubMed1986

Simultaneous determination of radio-immunoassayable methionine-enkephalin and radioreceptor-active opiate peptides in CSF of chronic pain suffering and non suffering patients.

Radio-immunoassayable methionine-enkephalin (ME) and radioreceptor-active opiate peptide levels (OP) were determined in CSF from patients, both with and without chronic pain, under investigation for vertebral disk disease. This study showed: that there was no direct correlation between ME and OP levels in CSF; OP levels were negatively correlated with the ME/OP ratio; migraine patients had higher levels of ME; ME concentrations were reduced in patients receiving anti-inflammatory drugs (nonsteroidal): patients with chronic pain (non migraine, no anti-inflammatory drug therapy) had lower ME levels than patients without pain. The data are discussed in relation to animal models of chronic pain.

Adolescent↗
PubMed1982

Vascular malformations of the mandible (intraosseous haemangiomas). The importance of preoperative embolization. A study of 9 cases.

Haemangiomas of the mandible are relatively rare arteriovenous malformations: 85 cases have been described since 1849. The severe risk of bleeding during tooth extraction or biopsy led us to describe the radiological and angiographic features of this condition. The afferent vessels are the inferior dental, the lingual, and the facial arteries. Preoperative embolization reduces the risk of bleeding at operation. Surgical treatment must assure the complete removal of the lesion. Radiotherapy and vascular ligatures are useless and dangerous.

Adolescent↗
PubMed1978

Effects of a diazepam-fentanyl mixture on cerebral blood flow and oxygen consumption in man.

The effects of a mixture of diazepam and fentanyl on cerebral blood flow (c.b.f.) and cerebral metabolism of oxygen (CMRo2) were studied in eight normal subjects and 13 patients with organic brain disease. The coupling of flow and metabolism and the carbon dioxide responsiveness of the c.b.f. were studied also. In the normal subjects the injection of the mixture resulted in a significant decrease in c.b.f. (34%), and a similar decrease in CMRo2 (34.5%). The vasoreactivity of the brain to carbon dioxide was maintained. C.b.f. decreased in all patients with intracranial pathology.

Brain↗