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Biomedical subjects

J Lu

Publications and source records attributed to J Lu.

At least 667 records · Page 37Linked to original sources
PubMed1990

Adenomatous hyperplasia and adenomas in the lung induced by chronic feeding of butylated hydroxyanisole of Japanese house musk shrew (Suncus murinus).

A carcinogenicity study on butylated hydroxyanisole (BHA) was carried out in Japanese house musk shrews (Suncus murinus) (suncus), which have no forestomach. BHA was mixed with the basal diet and was processed into pellets. One hundred and twenty-two female and 130 male suncus were maintained with a diet containing 0, 0.5, 1.0 or 2.0% BHA for 80 weeks. All of the suncus of the 2.0% BHA groups died of bleeding in the gastrointestinal tract within 8 weeks after the commencement of the treatment. The majority of the animals in the other groups survived for greater than 52 weeks. Adenomatous hyperplasias of the lung were induced in suncus of both sexes of the 0.5 and 1.0% BHA groups at significantly higher rates than in the control groups. Lung adenomas were also induced in three suncus of the BHA groups. Pilosebaceous and musk gland tumors, mammary carcinoma, kidney hemangioma and other tumors developed in a few suncus, with no significant differences between the groups. The present study indicates that BHA induces adenomatous hyperplasia of the lung in the suncus.

Adenoma↗
PubMed1990

Diverse forms of a receptor for acidic and basic fibroblast growth factors.

We recently reported the isolation of a chicken cDNA clone encoding a basic fibroblast growth factor (FGF) receptor that has three immunoglobulinlike domains in the extracellular region. We have now identified four unique human cDNA clones encoding previously unknown FGF receptor variants which contain only two immunoglobulinlike domains. Two of the human clones encode membrane-spanning receptors, and two encode putative secreted forms. Both the three- and two-immunoglobulinlike-domain forms mediate biological responsiveness to acidic and basic FGF. Thus, the first immunoglobulinlike domain of the three-domain form may have a function other than binding of acidic and basic FGF.

Amino Acid Sequence↗
PubMed1990

A model for urbanizing rural population and development measures: survey of a large specialized market in Xiliu town, Liaoning province.

The authors present an urbanization model using the example of Xiliu town in Liaoning province, China. Xiliu has developed from a rural commune into a large-scale clothing market during the period since 1979. "The purpose...is to show, by means of a survey conducted in the town, the characteristics and formative factors of the model and to discuss the prospect of and measures for furthering this development."

Asia↗
PubMed1990

[Nutritive physiology of Psoralea corylifolia L].

Our study has shown that P. corylifolia absorbs and accumulates N2 and K2O most speedily in the periods of branching, flowering and fruiting, while P2O5 in the period of full flowering and fruiting. P2O5 is accumulated mainly in the seed and K2O in the stem. The nutriment accumulation is positively correlated with that of dry substances. To produce 100 kg of P. corylifolia an absorption of 10.59 kg of N2, 3.68 kg of P2O5 and 10.21 kg of K2O is needed.

Fabaceae↗
PubMed1990

[Effect of seed soaking in plant hormone and trace element fertilizer on the growth of Psoralea corylifolia L].

Our study shows that seed soaking in triacontanol, ammonium molybdate and gibberellin can promote the growth of P. corylifolia, reduce its premature flower and fruit drop, raise the fruit-bearing rate by 6.5-17.4%, and fruit-bearing number by 21.6-28.4%, so as to increase the yield per unit area by 31.5-34.8%. Seed soaking in naphthylacetic acid and boric acid does not give such a marked effect.

Fabaceae↗
PubMed1990

[Detection of circulating antigen and/or antigen-antibody complex by using McAb against surface membrane antigen of adult Schistosoma japonicum].

In the present paper, the results of detecting circulating antigen and/or antigen-antibody complexes by McAb against surface membrane antigen of adult Schistosoma japonicum were reported. The McAb, coded as 8SE4, was prepared by fusion of SP2/0 myeloma cells with spleen cells of the BALB/c mice immunized with the saline extract of adult S. japonicum. The 8SE4- directed antigen was proved to be located on the surface of the adult worm. After being purified by a DE52 column, 8SE4 was labelled with HRP and the conjugate (HRP-8SE4) was used in the test. For testing, the serum sample was first incubated with HRP-8SE4, then PEG (mw. 6,000) was added to precipitate the antigen-antibody complex. Upon centrifugation, OPD was added to the precipitate. Results were read by ELISA reader at 492nm. The OD value was found to be proportional to the amount of circulating antigen and/or antigen-antibody complexes. Results from 5 heavily infected (1,500-2,000 cercariae) rabbits showed that the OD values were raised significantly at the 6th week post infection, being 1.9-4.5 times higher than those before infection. The OD values of the 5 rabbits each lightly infected with 10-500 cercariae were also markedly raised 6 weeks post infection and reached the peak at the 8th week, then maintained in high levels until 11th week post infection. The worm burden of the 5 lightly infected rabbits were 4-326. No obvious correlations between OD values and worm loads were observed. The results suggested the existence of surface membrane-related antigen and/or antigen-antibody complexes in the circulation of infected rabbits.

Animals↗
PubMed1990

[An approach to the pathologic basis of ultrasonography in hepatic hydatid disease].

The relationship between sonographic image and histological findings of 149 hepatic hydatid cysts was studied in 98 patients with primary hepatic hydatid disease. Sonographic classification was based on the morphology and structure of the cyst, which is thought to correspond to developmental stages of the hydatid cyst. The types were classified as follow: Type I: simple fluid-filled cyst denoted as the early stage of the disease; Type II: with undulated membrane representing detached endocyst secondary to rupture; Type III: with daughter cysts and a formed echogenic material called matrix; Type IV: solid cyst filled with matrix; Type V: calcified cyst. The latter two types were dead cysts, denoting the end of natural fate of the cyst. The natural progression of the cyst from Type I to Type V was correlated with increasing age of the patients. The rate of stainable protoscolices corresponded to the degree of damage of the germinal membrane, which could reflect the viability of hydatid cyst. The damage of germinal membrane happened earlier and was more severe than that of the protoscolices, being the biologic basis of transforming from type II into type III. Our study also showed that normal, damaged and dead cysts accounted for about 1/3 respectively in the clinical cases of hepatic hydatid disease, providing references for evaluating chemotherapeutic effects on hepatic hydatidosis.

Adolescent↗
PubMed1990

[Biological characteristics of Psoralea corylifolia L].

A study has been made on the biological characteristics of Psoralea corylifolia under general cultivating conditions. To search for the laws of growth and development so as to facilitate further studies on the cultivating techniques for higher production of Psoralea corylifolia.

Fabaceae↗
PubMed1990

[Anti-ulcer effects of weiteling tablets].

The traditional Chinese medicine Weiteling Pain shows a marked anti-ulcer action when administered orally at a dose of 3g/kg. The drug has been found able to inhibit the formation of stress restraint induced ulcer and reserpine induced ulcer. A decrease of volume of gastric juice collected from pyloric ligated stomachs and a reduced level of gastric acid have also been observed. In addition, the drug can reduce the inflammatory reaction of the acute gastritis induced by salicylate.

Animals↗
PubMed1989

Association of low levels of mannan-binding protein with a common defect of opsonisation.

Failure to opsonise bakers' yeast (Saccharomyces cerevisiae) is a defect found in 5-7% of the general population. In this study, the presence of the defect was linked with low levels of mannan-binding protein (MBP), a calcium-dependent serum lectin. Purified MBP corrected the defect in a dose-dependent way in an in-vitro assay measuring the deposition of complement moieties on a mannan-coated surface. There was a highly significant correlation between the serum MBP level and the generation of C3b opsonins in a population of healthy blood donors. The median MBP level of ten children previously shown to have the functional opsonic defect was 4.9 micrograms/l (range 2.5-35.0 micrograms/l) compared with 143 micrograms/l (range 2.5-880 micrograms/l) for a paediatric control group.

Adolescent↗
PubMed1989

Inhibitory effect of antibody against basic fibroblast growth factor on androgen- or glucocorticoid-induced growth of Shionogi carcinoma 115 cells in serum-free culture.

Shionogi carcinoma 115 (SC115) has been accepted for 20 years as an androgen-responsive mouse mammary tumor. However, we and others recently found that the growth of SC115 cells is also stimulated by high doses of glucocorticoids. We already reported the following findings. In a serum-free medium [Ham's F-12: Eagle's minimum essential medium (1:1, v/v) containing 0.1% bovine serum albumin], greater than or equal to 10(-9) M testosterone and greater than or equal to 10(-8) M dexamethasone significantly stimulated the growth of SC-3 cells (a cloned cell line from a SC115 tumor) through androgen and glucocorticoid receptors, respectively. In the present study, we have demonstrated that higher concentrations (10(-7)-10(-6) M) of weak androgens such as 4-androstene-3,17-dione or weak glucocorticoids such as corticosterone also significantly stimulate the growth of SC-3 cells and that their relative potency is found to be in parallel with their binding affinity for their receptors, respectively. Furthermore, DNA synthesis of SC-3 cells induced by 0.1 ng/ml basic fibroblast growth factor (FGF), 10(-8) M testosterone, 10(-6) M 4-androstene-3,17-dione, 10(-7) M dexamethasone, or 10(-6) M corticosterone was found to be similarly and significantly inhibited by the addition of basic FGF neutralizing antibody IgG in the present study; approximately 70% inhibition of the basic FGF, androgen, or glucocorticoid effects was attained. We already reported findings which suggest that SC-3 cells produce FGF-like peptide for their testosterone-induced growth. Therefore, the present study presents new additive information to demonstrate that the growth-stimulatory activity of various androgens or possibly glucocorticoids on SC-3 cells is mediated through a FGF-like peptide in an autocrine mechanism.

Androstenedione↗
PubMed1989

Growth-stimulatory effects of androgen, high concentration of glucocorticoid or fibroblast growth factors on a cloned cell line from Shionogi carcinoma 115 cells in a serum-free medium.

The effects of various kinds of growth factors or steroids on the proliferation of Shionogi carcinoma 115 (SC115) cells were investigated in cell culture. In a serum-free medium [Ham's F-12:Eagle's minimum essential medium (1:1, vol/vol) containing 0.1% bovine serum albumin], the proliferation of SC-3 cells (a cloned cell line from SC115 cells) estimated by [3H]thymidine incorporation into DNA and cell number reached a plateau at 10(-8) M testosterone (up to 200-fold), 10(-7) M dexamethasone (up to 30-fold) or 1 ng/ml of fibroblast growth factors (FGF; up to 50-fold). However, the proliferation in the serum-free medium was not significantly stimulated by the addition of low to very high concentrations of progesterone, oestradiol-17 beta, epidermal growth factor, platelet derived growth factor or insulin; transforming growth factor beta slightly stimulated the growth (up to 5-fold) but markedly inhibited the growth stimulation induced by testosterone. Furthermore, an epithelial appearance of SC-3 cells grown in the absence of growth factors or steroids was changed to a fibroblast-like appearance only by the addition of testosterone, high concentrations of dexamethasone or FGF. By investigating various kinds of growth factors or steroids, the present study demonstrates that androgen, high concentration of glucocorticoid or FGF alone significantly stimulates the proliferation of SC-3 cells with a change of morphology in the serum-free medium.

Animals↗
PubMed1989

A word of a natural language has 2.718 different meanings or slightly more.

The capacity of lexical decision-making in the brain conforms to the indefiniteness latent in natural languages. The average number of different meanings per word of a natural language is measured to be 2.805 +/- 0.005 irrespective of whether the language is Chinese, English or Japanese. If one can almost perfectly comprehend words and sentences written in a natural language in a context-dependent manner, the average number of different meanings per word would reduce to e (= 2.718281828459...), the base of natural or Napierian logarithms.

Humans↗
PubMed1989

Unique male mammary tumors developing in the inbred soft-furred field rats Millardia meltada.

Inbred lines of the soft-furred rat, Millardia meltada, were studied with special reference to spontaneous male mammary tumors. Adult males had the hyperplastic, pigmented inguinal mammary tissues and frequently developed bilateral mammary tumors. The tumors, no longer pigmented, were histologically well-differentiated adenocarcinomas associated with the myoepithelial cells and showed a variety of growth patterns depending on the stage of progression. They were transplantable to male, but not to female or castrated male nude mice. A significant number of androgen as well as estrogen binding sites were demonstrated in the nuclei of the transplanted tumor cells by in situ autoradiography. Neither virus particle nor mouse mammary tumor virus-specific antigen expression was detected in the tumor cells by electron microscopic and immunohistochemical studies. Normal females were generally free of pigment and tumor, although the androgen treatment induced marked pigmentation (deposit of nonfluorescent lipofuscin and hemosiderin) and hyperplasia of the female mammary epithelial cells, without a tumor. Possible relationships between pigmentation and tumor development were considered.

Animals↗
PubMed1989

[Observation of plasma levels of antithrombin-III and plasminogen in acute cerebrovascular disease].

In 75 patients with acute cerebral vascular disease (infarction 43, TIA 4, cerebral hemorrhage 25, subarachnoid hemorrhage 3), the plasma levels of Antithrombin-III (AT-III) and plasminogen (Plg) were measured within one week stroke patient and with 27 non-stroke patient as controls. The results showed: the plasma AT-III level was of no significant difference between the patients with hemorrhagic or ischemic cerebral vascular disease group and control group; the plasma plg level was a significant decrease in ischemic cerebral vascular disease groups (cerebral infarction. TIA), and it was of significant difference between the cerebral infarction group, or the TIA group and those of the control group (P less than 0.001 and P less than 0.01) respectively. In view of these results suggest that measuring of Plasma Plg level is a valuable unspecific assays indicator for ischemic cerebral vascular diseases. Finally, the relationship between high coagulation and acute cerebral vascular disease was discussed.

Adult↗
PubMed1988

Laparoscopic CO2 laser vaporization of endometriosis compared with traditional treatments.

This study reports on 108 infertile patients with endometriosis diagnosed at laparoscopy. Sixty-four patients had endometriosis and adhesions vaporized with a CO2 laser (LAS) and were prospectively compared with a control group (CON) of 44 patients who had laparoscopy. The 6- and 12-month estimated cumulative pregnancy rates for LAS were 0.32 +/- 0.07 and 0.55 +/- 0.09 respectively, and for CON 0.17 +/- 0.06 and 0.43 +/- 0.09 (Breslow P = 0.10). Monthly fecundity rates were 6.7% in LAS and 4.5% in CON. Survival analysis with fixed covariates showed that pregnancy rates were increased in patients with adhesions (P = 0.002) and other pelvic disease (P = 0.0001). Pregnancy rates were reduced by age (P = 0.02), previous adhesiolysis (P = 0.0000) and post-laparoscopy medical treatment (P = 0.0002). Our findings indicate that CO2 laser laparoscopy vaporization of endometriosis can be a safe, effective, and possibly improved modality for treating endometriosis.

Actuarial Analysis↗