[Serum trypsin inhibition capacity in pleuropulmonary pathology].
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Adult↗
Biomedical subjects
J Lonsdorfer
Publications and source records attributed to J Lonsdorfer.
[Spirometric reference values in black females].
The aim of this paper is to give spirometric reference values for black females. Having eliminated those with abnormal hemoglobin, we studied 298 females aged between 10 to 70 years: 15 from bordering countries of the Ivory Coast and the others being Ivorian. That is, they are all from West Africa. It is shown that FVC and FEV1 are reduced in the black population when compared with European whites. Volume and flow values are also lower than those in Ivorian men. Correlations and linear regression equations were calculated between FVC, FEV1 and age, height, and weight. FVC and FEV1 (l BTPS) were found as a function of height H (m) and age A (years) as follows: from 10 to 25 years, FVC = 0.465 H3 + 0.01735 A + 0.58; FEV1 = 0.451 H3 + 0.0035 A + 0.61; from 25 to 70 years, FVC = 0.450 H3 - 0.02002 A + 1.54; FEV1 = 0.309 H3 - 0.02050 A + 1.44.
Adolescent↗
Cardiorespiratory adjustments in chronic sickle cell anemia.
During the intercrisis periods, patients homozygous for sickle cell anemia (SS) show clinical symptoms of severe impairment of oxygen transport mechanisms. We have determined respiratory lung function tests, arterial and venous blood gases and cardiocirculatory parameters in 39 SS patients (mean age 22 +/- 5 yr) at distance from any vaso-occlusive crisis or blood transfusion. The patient group was compared to subjects homozygous for HbA (AA) of the same ethnic origin. Determinations were made at rest and after a 5 min mild exercise period. The main alterations in oxygen transport parameters observed in SS patients were: 1) a moderate reduction in vital capacity and maximal ventilation (pure restrictive syndrome), 2) an arterial hypoxemia which worsened the already low oxygen content of blood due to anemia, and 3) a low arterio-venous oxygen saturation difference which is very surprising in anemic patients. The normal oxygen consumption rate was thus insured by a 70% increase of the cardiac output at rest. A particular abnormality found in SS patients was the high Po2 in mixed venous blood. The decreased affinity of blood for oxygen resulting from the polymerization of HbS in the erythrocytes led to an almost normal venous blood unsaturation and thus a decreased release of oxygen from this anemic blood. These results indicate that peripheral blood flow was permanently increased in SS patients. This may be in part at the origin of the arterial hypoxemia induced by an increased pulmonary blood shunting. Sickle cell anemia is more severe than other anemias of comparable intensity as, due to the sickling process, these patients appear to be at the upper limit of physiological compensatory mechanisms usually encountered in chronic anemia.
Adolescent↗