Beneficial effects of ticlopidine on cardiopulmonary function of sickle cell patients not in crisis.
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Biomedical subjects
Publications and source records attributed to J Lonsdorfer.
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Arterial pyruvate and lactate concentrations were measured after short heavy submaximal exercise on a bicycle ergometer, at 10 or 30 s time intervals, on six male subjects. During most of the first 2 min of recovery pyruvate concentration decreased. Thereafter, it increased and reached its maximum within the 5th to 9th min of recovery. Finally, it decreased gradually as a function of time. Recovery curves could be accurately described after a short delay time following the end of the exercise, by a sum of three exponential terms according to the equation: (Formula: see text), where the time origin (to) is fixed at about 1-1.5 min(delay time) after the end of exercise, t is the time after to, Y(O) and Y(t) are the concentrations of pyruvate respectively at times zero and T, and Ai and zi are constants. The velocity constant of the final arterial blood pyruvate decrease was similar to that of the simultaneously measured lactate, indicating that the rate of lactate removal is closely related to that of pyruvate. This is consistent with the fact that pyruvate is a necessary intermediate in the lactate metabolism.
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After description of a method of continuous measurement of partial pressure of blood gases, the authors describe the technical difficulties : behaviour of the electrodes, problems associated with continuous measurement, and emphasise the influence of the method on the results, e.g. heparinisation, blood flow rate, quantity of blood consumed. The results obtained under suitable physiological conditions show the difficulty of interpretation of continuous measurement of gaseous parameters and show interest in short but significant function tests.
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The aim of this publication is to contribute to the establishment of reference values for the forced expiratory flow between 25 and 75% of the vital capacity (FEF25-75) among black females in West Africa. 316 of them, aged between 10 and 70 years, were submitted to this test. They were considered free from cardiopulmonary disease after a questionnaire and clinical examination. FEF25-75 in absolute value was lower than in the white Euro-americans. It increased up to 18-19 years of age, then decreased steadily thereafter. The main equations of regression for the FEF25-75 (l X s-1) were: 10-18 years, 0.177A + 1.058 and 0.157A + 0.826H + 0.005; 19-70 years, -0.028A + 4.211 and -0.025A + 2.206H + 0.512, (where A is the age in years and H the height in metres). The results are compared with the reference values published in Black Africa, Europe and the United States.
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