Biomedical subjects

J Link

Publications and source records attributed to J Link.

At least 37 records · Page 2Linked to original sources

PubMed2001

[The problem with endoleakage in endoluminal therapy].

Endovascular treatment of aortic aneurysms with stent grafts was performed increasingly in recent years. The most frequent complication after endovascular therapy of aortic aneurysms is an endoleak. In case of a persistent endoleak, diameter of the aneurysm is increasing with a high risk of aneurysm rupture. Diagnostic tools are spiral computed tomography and angiography. Spiral computed tomography is the most sensitive method for the diagnosis of an endoleak ad should be performed with a biphasic acquisition. In- and outflow of sidebranches can be identified correctly with selective angiography in 86%. Perigraft endoleaks should be treated in any case. Patent side branches generally are observed over a period of 6 months. After 6 months approximately half of these endoleaks are thrombosed. Is there an increasing of the diameter of the aneurysm or any changing in the morphology of the aneurysm there is an indication for embolisation of these sidebranches of the aneurysmal sac. Preinterventional embolisation of patent sidebranches is under discussion. Type I endoleaks can be managed by additional stent-graft implantation or coil embolisation. In case of type II endoleaks in- ad outflow vessles should be embolised with coils. Therapy of type III endoleak is performed mostly by additional stent-graft placement. The total incidence of secondary interventions in the Eurostar-study was nearly 10% per year.

Aortic Dissection↗

PubMed2001

[Central retinal artery occlusion. Importance of selective intra-arterial fibrinolysis].

BACKGROUND: Conventional treatment of a central retinal artery occlusion usually has a poor prognosis but intra-arterial fibrinolysis (IF) of the ophthalmic artery is an invasive treatment option. The importance of IF was evaluated in 62 patients with central retinal artery occlusion and in addition the risk spectrum for this disease was considered. MATERIAL AND METHODS: Data from charts of 62 patients were retrospectively analysed. Visual recovery after IF (n = 17) was compared to conventional treatment (e.g. decrease of IOP, improvement of rheological conditions, n = 45). Patients were excluded from IF if the occlusion was present for more than 8 h, if there was a history of bleeding and previous operations, or if they were older than 85 years. IF was performed using either urokinase (n = 7) or tPA (n = 10). RESULTS: Out of 62 patients, 22 (35%) with central retinal artery occlusion underwent catheterisation. Stenosis of the carotid artery excluded IF in 5 out of these 22 cases, therefore only 17 patients were treated by IF. Of the patients, 40 (65%) were excluded from IF for various reasons: 47% (19/40) arrived later than 8 h after occlusion, 17% (7/40) did not consent to IF, 15% (6/40) had medical contraindications and 13% (5/40) were over 85 years of age. Two patients required no IF because of a cilioretinal anastomosis with moderate visual acuity and another patient showed spontaneous visual recovery during ophthalmic examination. Of the 17 patients treated with IF, 4 achieved an improvement of visual acuity by more than 2 lines, no change of visual acuity was observed in 12/17 patients and 1/17 lost more than 2 lines after treatment. Of the 45 conservatively treated patients, 16 achieved improvement by more than 2 lines and no change occurred in 29/45 patients. Three patients treated with IF suffered from a stroke during treatment. The main risk factor for central retinal artery occlusion was high blood pressure in 32% of all cases and nicotine abuse in 16%. CONCLUSIONS: Many patients presented too late for IF. However, there was no statistical difference between patients with IF and conventional treatment with regards to the improvement of visual acuity. Additionally there is an increased risk of a stroke from IF, therefore a prospective study is necessary to evaluate the importance of IF. Stabilisation of high blood pressure may be the best prophylaxis for preventing a central retinal artery occlusion.

Adult↗

PubMed2001

Treatment of infrapopliteal occlusive disease by high-speed rotational atherectomy: initial and mid-term results.

PURPOSE: To assess the effectiveness and patency rates of high-speed rotational atherectomy (HSRA) for the treatment of infrapopliteal arterial occlusive disease. MATERIAL AND METHODS: During an 18-month period, a total of 19 infrapopliteal lesions in 15 consecutive patients were treated primarily by HSRA with use of the Rotablator device. Patients were followed up with documentation of clinical symptoms, standardized treadmill exercise, and Doppler sonography at 1, 3, and 6 months. Control angiography was performed 6 months after primary treatment. RESULTS: HSRA was initially successful in 14 of 15 patients, yielding an initial technical success rate of 94%. Percutaneous treatment induced an improvement of the ankle-brachial index (ABI) from 0.6 +/- 0.09 to 0.86 +/- 0.2 after intervention (P < .0001). Doppler analysis showed a mean ABI of 0.85 +/- 0.2 (P < .001) at 1 month, 0.72 +/- 0.2 (P = .012) at 3 months, and 0.7 +/- 0.2 (P = .08) at 6 months after initial therapy. Although six patients were lost to follow-up at various times, control angiography at 6 months was carried out in nine of 15 patients, allowing direct assessment of 12 of 19 treated lesions. Among six high-grade restenoses and five total occlusions in the treated vascular segments, only one arterial lumen (of 12) remained patent without presenting a hemodynamically relevant restenosis. These results led to termination of the study. CONCLUSION: Although HSRA for the treatment of infrapopliteal occlusive disease yields a very high initial technical success rate, mid-term results are extremely poor. Therefore, HSRA cannot be recommended for primary treatment of this type of lesion.

Aged↗

PubMed2001

[Percutaneous transpapillary extraction of biliary calculi for symptomatic choledocholithiasisafter unsuccessful endoscopic treatment].

PURPOSE: Evaluation of a percutaneous transhepatic treatment of symptomatic choledocholithiasis in bile ducts that cannot be reached with the endoscope. METHODS: From January 1996 to August 2000 a transhepatic extraction of biliary calculus was performed in four patients. Endoscopic retrograde cholangiography (ERC) was not successful in any of the cases. Clinical symptoms were icterus in four cases, additional cholangitis or colics in two cases. First, a balloon dilation of the papilla was performed by a percutaneous transhepatic approach. For removal of bile duct stones, occlusion catheters and Dormia baskets were used. Technical success was defined as complete removal of bile duct stones. Clinical success was defined as normalization of cholestasis and inflammation parameters. In the follow-up an ultrasound examination was performed and blood samples were taken for control of cholestasis parameters. RESULTS: In all four cases treatment was technically and clinically successful. For complete removal of biliary calculus a second intervention was necessary in two cases. In each case an internal to external drainage was left over a mean of 7 days (3-13 days). In the mean follow-up of 30.5 months (6-50 months) all patients had persistent relief of symptoms. No further interventions were necessary. No complications were present. CONCLUSION: Percutaneous transpapillary extraction of biliary calculus is an effective alternative to surgery in patients with bile ducts, that cannot be reached with the endoscope.

Aged↗

PubMed2001

[Results after placement of Memotherm stents in iliac and femoral arteries].

PURPOSE: To evaluate the effectivity, safety and midterm patency rates of iliac and femoral stent placement with the Memotherm stent (Bard-Angiomed, Karlsruhe). MATERIAL AND METHODS: In 41 patients (11 female, 30 male, mean age 63.9 years) 49 lesions were treated with 50 stents. Mean lesion length was 4.8 cm for 5 occlusions and 3.1 cm for 44 stenoses. Lesions were located in the common iliac (n = 31), the external iliac (n = 15), and the common femoral artery (n = 3). Patients were followed-up clinically, with ankle-brachial indices (ABI), and angiography. Angiographic patency rates (< or = 50% restenosis) were calculated using the Kaplan-Meier method, ABIs were compared before and after therapy with the Wilcoxon test. RESULTS: An immediate technical success was achieved in 48/49 lesions (98%, intention-to-treat). Visibility of the stent was poor. Four stent placement procedures were complicated by an advancement of the stent, which could not be corrected. A thrombosis of one stent during deployment had to be treated surgically. After a mean of 10.4 months (6-24) 33 lesions were followed-up with angiography. The primary angiographic patency rate was determined to be 89.9% after 9 months. An improvement of at least one Fontaine stage was observed in 85.4%. The mean ABI increased significantly from 0.64 to 0.84 after therapy. CONCLUSIONS: The patency rate of the Memotherm stent is comparable to that of other stent systems. The poor visibility and the advancement of the stent during deployment requires further modifications.

Aged↗

PubMed2001

[Percutaneous transfemoral implantation of a new, flexible thoracic aorta endoprosthesis using a percutaneous suture system for vascular suture--initial experiences].

PURPOSE: To evaluate the transfemoral placement of a new, flexible stent-graft into the thoracic aorta and the suture-mediated closure of the femoral access. PATIENTS AND METHODS: Five patients were treated endovascularly with a stent-graft for an aneurysm (n = 3) or acute dissection (n = 2) of the thoracic aorta via a femoral 24 F sheath. The femoral access site was closed with two suture-mediated closure devices after placement of the stent-graft. RESULTS: The aneurysm or the false lumen was excluded from perfusion by the placement of the stent-graft in all patients. Hemostasis at the femoral access site was successful in all patients with the percutaneous suture device. A minor stenosis of the femoral artery was found angiographically in four patients after suture-mediated closure. Besides a reversible renal failure due to the medically induced hypotension for the treatment of an acutely ruptured aneurysm, no complications resulted from the stent-graft placement or the percutaneous suture. CONCLUSION: The percutaneous transfemoral placement of stent-grafts in the thoracic aorta using a suture-mediated closure of the access site is technically feasible. Long-term results of the technique have to be awaited.

Aged↗

PubMed2001

[Treatment of para-ostium renal artery stenoses with a new, solidly premounted balloon expandable stent].

PURPOSE: Evaluation of the handling, technical success rate, and six-months patency rate of a new, premounted balloon-expandable stent in ostial renal artery stenoses. MATERIAL AND METHODS: In a prospective study, 27 ostial renal artery stenoses in 20 patients were primarily treated with the new "Renal Bridge Stent" (Medtronic AVE, Düsseldorf). All patients had a history of hypertension and 8 patients had renal dysfunction. The handling and visibility of the stent was scored on a three grade scale by the operators. Follow-up angiography including intra-arterial trans-stenotic pressure measurements was performed in 23 out of 27 stenoses (17 patients). RESULTS: Handling and visibility were scored as good by all operators. 26 of 27 stenoses were treated with technical success by implantation of 28 stents. The mean degree of stenosis was reduced from 74.2% to less than 5%. At 6 months, 8 stents out of 23 (35%) showed a significant in-stent stenosis (stenosis degree > 50% and intra-arterial pressure gradient > 10 mmHg). The stenosis rates were 63% using 5-mm stents, 30% using 6-mm stents, and 0% using 7-mm stents. CONCLUSION: Endovascular treatment of ostial renal artery stenosis with the used stent is safe and effective. The new stent shows a good handling and visibility. The high rate of in-stent stenoses might be explained by the rigid follow-up protocol including angiography, trans-stenotic pressure measurements, and the high number of 5-mm vessels in our study.

Adult↗

PubMed2001

[CT-guided thoracal sympathicolysis for the treatment of peripheral arterial occlusive disease and chronic thoracal pain syndromes in 6 patients].

UNLABELLED: CT-guided thoracal sympathicolysis for the treatment of peripheral arterial occlusive disease and chronic thoracal pain syndromes in 6 patients. PURPOSE: Retrospective evaluation of the safety and effectivity of CT-guided percutaneous thoracal sympathicolysis (CT-TSL) in the treatment of patients with peripheral arterial occlusive disease (PAOD) of the upper limb and chronic thoracal pain syndromes. Comparison of our own experience with literature reports. MATERIAL AND METHODS: Between 6/96 and 12/99, 4 patients with PAOD of the upper limb and two with chronic thoracal pain syndromes caused by herpes zoster were treated by unilateral CT-TSL. RESULTS: 18, 21 and 32 months after the intervention 3 out of 4 patients treated for PAOD reported subjective improvements, and one remained unchanged. Two patients treated for pain syndromes showed no long-term benefit of the procedure. There were no serious complications. CONCLUSION: The CT-TSL is an alternative method in the treatment of PAOD in patients who are unsuitable for treatment by revascularization.

Aged↗

PubMed2001

[Indirect MR Arthrography of the wrist in the diagnosis of TFCC-Lesions].

PURPOSE: The objective of this prospective study was to assess the value of the indirect MR arthrography (MR-AR) of the wrist in the detection of lesions of the TFCC. MATERIAL AND METHODS: Indirect MR-AR was performed in 45 patients (23 f/22 m) with unclear ulnar wrist pain. After i. v. injection of 0.1 mmol/kg Gd-DTPA and after a motion-phase of the wrist (15 minutes) MRI was performed in a coronal plane. We used a STIR-, a fatsaturated (fs) T1-SE and a 3D-DESS sequence. The images were evaluated by two radiologists using a consensus score. The lesions were assigned to the system of Palmer and correlated with arthroscopy. RESULTS: Indirect MR-AR showed in 35 of 45 patients a lesion of the TFCC, but arthroscopy only revealed a defect in 32 cases. This means three false positive but no false negative assessments by MRI. Using this MRI protocol sensitivity and specificity in the detection of TFCC lesions were calculated as 100 % and 77 %. The accuracy was 93 %. Small degenerative changes of the fibres were most common (Palmer type II A). In trauma patients the ligaments usually showed tears near the insertion at the ulna (Palmer type I B). The sensitivity and specificity was 88 % and 95 % for evaluation of the scapho-lunate (SL) ligament, the accuracy was 93 %. Arthroscopy and MRI did not diagnose any rupture of the lunate-triquetral (LT) ligament. CONCLUSION: Indirect MR-AR is a non-invasive method with a high sensitivity in the evaluation of the TFCC and associated injuries. Therefore, it is an excellent screening procedure to assess the indication for therapeutic arthroscopy.

Adolescent↗

PubMed2001

MR imaging-guided stent placement in iliac arterial stenoses: a feasibility study.

PURPOSE: To assess the feasibility of magnetic resonance (MR) imaging-guided stent placement in iliac arterial stenoses. MATERIALS AND METHODS: Thirteen patients with 14 iliac arterial stenoses were examined prospectively. Angioplasty was performed through a femoral sheath by using a conventional 1.5-T MR imaging system. Stents and catheters were visualized on the basis of their artifacts. Nitinol stents were placed with gradient-echo MR imaging guidance. Angioplasty balloons were inflated with gadolinium-based contrast material. Results were evaluated clinically and with both digital subtraction angiography (DSA) and contrast material-enhanced MR angiography. RESULTS: Ten of 13 patients were treated with technical success by using MR imaging-guided intervention alone. Three patients were treated with additional fluoroscopic guidance, because complications (ie, panic attack, subintimal recanalization, and stent misplacement) occurred with MR guidance. The quality of the postinterventional contrast-enhanced MR angiograms of three of 12 lesions with stents was limited owing to stent-induced signal loss of the lumen. The mean stenosis degree after stent placement was significantly higher at contrast-enhanced MR angiography than at DSA (24.6% vs 6.2%). The mean MR imaging-guided procedure time was 74 minutes. CONCLUSION: MR imaging-guided stent placement in iliac arteries is feasible in select patients. The presented technique has limitations-that is, long procedure times, lack of real-time monitoring, and stent artifacts-that necessitate further modifications before it can be recommended for clinical use.

Aged↗

PubMed2001

Renal time-resolved MR angiography: quantitative comparison of gadobenate dimeglumine and gadopentetate dimeglumine with different doses.

PURPOSE: Results with different doses of gadobenate dimeglumine and gadopentetate dimeglumine were compared at magnetic resonance (MR) angiography of the renal arteries. The signal-to-noise ratio (SNR) was evaluated as a quantitative measure of image quality. MATERIALS AND METHODS: Sixty consecutive patients (age range, 24-81 years; mean age, 65 years) underwent intraarterial digital subtraction angiography (DSA) and contrast material-enhanced time-resolved MR angiography. DSA was the standard of reference. Fifteen patients received gadopentetate dimeglumine at doses of 0.2 or 0.1 mmol per kilogram of body weight. Fifteen patients received gadobenate dimeglumine at doses of 0.05 or 0.1 mmol/kg. The SNR was calculated in the aorta and both main renal arteries. The number and degree of stenoses of the renal arteries and accessory vessels were evaluated by four observers. RESULTS: SNRs with gadobenate dimeglumine at a dose of 0.1 mmol/kg were significantly superior to those with gadopentetate dimeglumine at a dose of 0.1 mmol/kg. Differences were not statistically significant between the SNRs in the other groups. Eleven (85%) of 13 hemodynamically significant renal artery stenoses were detected correctly with MR angiography as were 22 (85%) of 26 accessory renal arteries. CONCLUSION: SNRs with gadobenate dimeglumine were higher than those with gadopentetate dimeglumine, but in most cases the differences in SNRs were not statistically significant.

Adult↗

PubMed2000

Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin.

The mouse aspartyl beta-hydroxylase gene (Asph, BAH) has been cloned and characterized. The mouse BAH gene spans 200 kilobase pairs of genomic DNA and contains 24 exons. Of three major BAH-related transcripts, the two largest (6,629 and 4,419 base pairs) encode full-length protein and differ only in the use of alternative polyadenylation signals. The smallest BAH-related transcript (2,789 base pairs) uses an alternative 3' terminal exon, resulting in a protein lacking a catalytic domain. Evolutionary conservation of this noncatalytic isoform of BAH (humbug) is demonstrated in mouse, man, and Drosophila. Monoclonal antibody reagents were generated, epitope-mapped, and used to definitively correlate RNA bands on Northern blots with protein species on Western blots. The gene for mouse junctin, a calsequestrin-binding protein, was cloned and characterized and shown to be encoded from the same locus. When expressed in heart tissue, BAH/humbug preferably use the first exon and often the fourth exon of junctin while preserving the reading frame. Thus, three individual genes share common exons and open reading frames and use separate promoters to achieve differential expression, splicing, and function in a variety of tissues. This unusual form of exon sharing suggests that the functions of junctin, BAH, and humbug may be linked.

Amino Acid Sequence↗

PubMed2000

Assembly of U7 small nuclear ribonucleoprotein particle and histone RNA 3' processing in Xenopus egg extracts.

In animals, replication-dependent histone genes are expressed in dividing somatic cells during S phase to maintain chromatin condensation. Histone mRNA 3'-end formation is an essential regulatory step producing an mRNA with a hairpin structure at the 3'-end. This requires the interaction of the U7 small nuclear ribonucleoprotein particle (snRNP) with a purine-rich spacer element and of the hairpin-binding protein with the hairpin element, respectively, in the 3'-untranslated region of histone RNA. Here, we demonstrate that bona fide histone RNA 3' processing takes place in Xenopus egg extracts in a reaction dependent on the addition of synthetic U7 RNA that is assembled into a ribonucleoprotein particle by protein components available in the extract. In addition to reconstituted U7 snRNP, Xenopus hairpin-binding protein SLBP1 is necessary for efficient processing. Histone RNA 3' processing is not affected by addition of non-destructible cyclin B, which drives the egg extract into M phase, but SLBP1 is phosphorylated in this extract. SPH-1, the Xenopus homologue of human p80-coilin found in coiled bodies, is associated with U7 snRNPs. However, this does not depend on the U7 RNA being able to process histone RNA and also occurs with U1 snRNPs; therefore, association of SPH1 cannot be considered as a hallmark of a functional U7 snRNP.

3' Untranslated Regions↗

PubMed2000

[Carotid endarterectomy and carotid stenting. A pilot study of a prospective, randomized and controlled comparison].

INTRODUCTION: A prospective, randomized and controlled trial is conducted to compare carotid endarterectomy and carotid stenting in high grade symptomatic carotid artery stenoses. METHODS: According to the study design symptomatic patients with a angiographically high-grade (> or = 70%) internal carotid artery stenosis are included. Pre- and postinterventional diagnostics during the hospitalization period includes neurological assessment, duplex sonography of the cervical and cerebral arteries and magnetic resonance imaging of the brain. Follow-up examinations are scheduled after 1, 6 and 12 months and consist of a neurological assessment and duplex sonography. After 12 months selective angiography and magnetic resonance imaging of the brain will be performed additionally. During a period of 9 months up to now 23/137 patients treated for a carotid artery stenosis were included in the study, 11 patients underwent surgery and 12 patients carotid stenting. RESULTS: Carotid stenting and endarterectomy was primarily successful without residual stenosis > 30% in each patient without the occurrence of stroke or death. In 18 follow-up examinations (neurological assessment including duplex sonography) of 13 patients (13 follow-up examinations after 30 days, 5 after 6 months) no relevant restenosis and no stroke occurred. CONCLUSION: As of yet, carotid stenting was a safe procedure. Due to the small number of patients a definitive conclusion can not be drawn.

Angiography, Digital Subtraction↗

PubMed2000

Digital radiography of the skeleton using a large-area detector based on amorphous silicon technology: image quality and potential for dose reduction in comparison with screen-film radiography.

AIM: The purpose of this study was to evaluate a large-area, flat-panel X-ray detector (FD), based on caesium-iodide (CsI) and amorphous silicon (a-Si) with respect to skeletal radiography. Conventional images were compared with digital radiographs using identical and reduced radiation doses. MATERIALS AND METHODS: Thirty consecutive patients were studied prospectively using conventional screen-film radiography (SFR; detector dose 2.5 microGy). Digital images were taken from the same patients with detector doses of 2.5, 1.25 and 0.625 microGy, respectively. The active-matrix detector had a panel size of 43 x 43 cm, a matrix of 3 x 3K, and a pixel size of 143 microm. All hard copies were presented in a random order to eight independent observers, who rated image quality according to subjective quality criteria. Results were assessed for significance using the Student's t -test (confidence level 95%). RESULTS: A statistically significant preference for digital over conventional images was revealed for all quality criteria, except for over-exposure (detector dose 2.5 microGy). Digital images with a 50% dose showed a small, statistically not significant, inferiority compared with SFR. The FD-technique was significantly inferior to SFR at 75% dose reduction regarding bone cortex and trabecula, contrast and overall impression. No statistically significant differences were found with regard to over- and under-exposure and soft tissue presentation. CONCLUSION: Amorphous silicon-based digital radiography yields good image quality. The potential for dose reduction depends on the clinical query.

Aged↗

PubMed2000

[Stent angioplasty of pelvic artery stenosis with MRI control: initial clinical results].

PURPOSE: To investigate the feasibility of MR-guided stent angioplasty of iliac artery stenoses under passive visualization. MATERIAL AND METHODS: Three patients with short, concentric stenoses of the iliac arteries were enrolled. The vascular interventions were performed on a 1.5 T MR scanner (Magnetom Symphony, Siemens, Erlangen, Germany). Stents, guidewires, and balloon catheters were visualized on the basis of susceptibility artifacts. Contrast-enhanced MR angiography (ceMRA) was used to localized the stenosis prior to stent deployment. Nitinol stents were placed under MR-guidance using a fast 2D gradient echo technique. Balloon dilatiation was performed with an angioplasty catheter inflated with diluted gadolinium-DTPA. Postinterventional results were evaluated by ceMRA, DSA, and Doppler indices. RESULTS: Position of the stent, stent deployment, and balloon dilatation were depicted by MR. All stents were correctly placed within the stenosis. Stent positions as monitored by MRI were identical to those seen on DSA images. All patients were treated successfully by the MR-guided intervention. CONCLUSION: An MR-guided stent angioplasty of simple iliac artery stenosis is feasible under passive visualization.

Aged↗

PubMed2000

[Digital subtraction angiography of the extremities using step-translation technique].

PURPOSE: To evaluate, how routine application of i.a. DSA with the step-translation technique using a single contrast bolus can effectively reduce radiation exposure and the amount of contrast media in comparison to standard peripheral DSA. METHOD/MATERIALS: 100 patients with peripheral arterial occlusive disease were assessed with step-translation DSA, 100 with standard DSA using the same equipment. Imaging quality was rated two observers, judgement by consensus. Comparison of the technical data (radiation dose, contrast media) was based on pairs of patients with similar constellations of stenoses to reduce selection bias. RESULTS: Step-translation DSA was of high imaging quality from the iliac vessels to the popliteal artery. In the distal leg, imaging was often impaired by effects like unilaterally delayed contrast flow due to high grade stenosis or motion artifacts. 53% of the step translation DSA required 1 or 2, 29% more than two additional DSA runs. Including the additional runs, the average radiation exposure and the amount of contrast media (2434 cGycm2/128 ml) were comparable to those of standard DSA (2461 cGycm2/144 ml). CONCLUSIONS: Step-translation DSA provides high quality images. In routine application realization of the advantages over standard DSA such as reduction of examination times, radiation exposure and amounts of contrast media may be impaired by poorly collateralized stenoses or motion artifacts demanding additional series.

Aged↗

PubMed2000

[CT-guided biopsies, drainage and and percutaneous gastrostomies: comparison of punctures with and without CT fluoroscopy].

PURPOSE: The purpose of this prospective and randomized study was to compare two CT guidance techniques (CT-fluoroscopy/conventional CT) on percutaneous biopsies, drainages and gastrostomies. MATERIAL AND METHODS: 78 CT-guided interventions (29 biopsies, 38 drainages, 8 gastrostomies) were recorded and the Mann-Whitney U-test was applied. In 3 cases both guidance techniques were used. Procedure times, yields and radiation doses were analyzed. RESULTS: All 38 drainages and all 8 gastrostomies were successfully applied. 13 biopsies with conventional CT guidance (n = 15) and 13 biopsies with CT-fluoroscopy (n = 14) showed a representative histopathologic result. The procedure times were not significantly different (drainages: p = 0.658, biopsies: p = 0.431, gastrostomies: p > 0.06). The radiation doses (CTID1) of the biopsies and drainages showed significantly higher values (drainages p < 0.001, biopsies p < 0.001) with CT-fluoroscopy than with conventional CT. There were no significant differences in gastrostomy procedures (p > 0.06). CONCLUSION: Procedure times and yields were not improved by using CT-fluoroscopy. Radiation doses showed significantly higher values with CT-fluoroscopy than with conventional CT guidance. CT-fluoroscopy was advantageous in non-compliant patients over conventional CT guidance.

Adult↗