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Biomedical subjects

J Lind

Publications and source records attributed to J Lind.

At least 73 records · Page 4Linked to original sources
PubMed1992

Quality of life during rehabilitation after coronary artery bypass surgery.

The effect of a three-phase comprehensive rehabilitation programme on the quality of life during the first postoperative year after coronary artery bypass surgery was studied in 205 male patients randomly allocated into a rehabilitation (R) and a hospital-based treatment (H) group. The rehabilitation programme included physical exercise, relaxation training, psychological group sessions, dietary advice and discussions about postoperative treatment of coronary disease. There was no difference between R and H groups in the frequency of postoperative complaints, number of hospital admissions and satisfaction of sexual life. An almost significantly greater number of subjects in R group than in H group perceived their health as good 12 months after surgery. The Beck Depression Index score decreased significantly in R group but not in H group during follow-up. A greater increase in hobby activities was observed in R group than in H group. More subjects in R group than in H group considered rehabilitation important for recovery, whereas more patients in H group considered support by the spouse and family, the subjective mental strength and a secure income as important.

Adult↗
PubMed1992

Tumor cell growth and cell kinetics.

Cancer cells differ from normal cells in many ways, but most importantly by not responding to normal growth-control mechanisms. Whereas the growth and division of normal cells is carefully regulated to meet the needs of the body, tumor cells proliferate autonomously and continually, eventually interfering with and destroying the functions of normal tissue. Knowledge of molecular cell biology has grown exponentially over the last decade. Yet much remains to be understood before there can be a significant impact on our ability to design more effective therapeutic strategies for cancer patients, thereby decreasing mortality.

Antineoplastic Agents↗
PubMed1991

Multiple DNA rearrangements in the BCL2 region in a patient with follicular lymphoma.

A 39-year-old male with follicular non-Hodgkin's lymphoma was repeatedly studied with respect to DNA rearrangements with the two probes pFL-1 and pFL-2, representing two segments of chromosome 18. The oncogene BCL2, detected by pFL-1, was as expected translocated to the J region of the immunoglobulin locus. The standard BCL2 translocation was found in three samples, one obtained at diagnosis, one ten months later, and one after 5 years. Another translocation was found with the probe pFL-2 hybridizing with a region located about 20 kb 3' from BCL2. This latter rearrangement was found only in the first biopsy, which was obtained at the time of diagnosis, but not in the two later samples, when the morphology of the lymphoma was unchanged. No cytotoxic therapy had been given in the interval from diagnosis to disappearance of the latter rearrangement. Thus, one of the observed translocations (pFL-2) was detected only in the first biopsy, while the other (pFL-1) was a clonal marker in all three biopsies. The finding suggests that clonal evolution does not necessarily mean clinical progression.

Adult↗
PubMed1991

Concentrations of neuropeptides substance P, neurokinin A, calcitonin gene-related peptide, neuropeptide Y and vasoactive intestinal polypeptide in synovial fluid of the human temporomandibular joint. A correlation with symptoms, signs and arthroscopic findings.

Arthroscopy was performed on 18 patients (19 joints) with temporomandibular joint arthropathy. Arthroscopic investigation revealed that 12 patients had disk derangement, including 3 patients with rheumatoid arthritis. Six patients had osteoarthrosis, including one patient with rheumatoid arthritis. Synovial fluid content of substance P-like immunoreactivity (SP-LI), neurokinin A (NKA-LI), calcitonin gene-related peptide (CGRP-LI), neuropeptide Y (NPY-LI) and vasoactive intestinal polypeptide (VIP-LI) were analysed using radioimmunoassay technique. All peptides analysed were found, although in various concentrations, in the different joints. There were no significant differences in concentrations of the peptides in the synovial fluid between patients in the various groups. No significant correlation was found between clinical symptoms and signs, arthroscopic findings, or use of analgesic/anti-inflammatory medication versus concentrations of peptides in the synovial fluid. In comparison with earlier findings in the knee joint significantly higher concentrations of SP-LI, CGRP-LI and NPY-LI were found in the TMJ.

Adult↗
PubMed1991

[Osteomalacia of the semilunar bone].

The aetiology of avascular necrosis of the carpal lunate remains unknown. Kienböck's disease was long misinterpreted as gout, tendinitis or a sequela of subluxation. The diagnosis is obtained by x-ray of the wrist, which should not be delayed in cases of diffuse wrist pain, limitation of motion, or reduced strength in the hand. A good prognosis is closely correlated to early diagnosis. This review is focused on new biomechanical analyses and treatment methods for use in cases of Kienböck's disease.

Adult↗
PubMed1991

The influence of smoking on complications after primary amputations of the lower extremity.

A total of 165 primary above-the-knee (AK) and below-the-knee (BK) amputations in 137 patients were reviewed retrospectively. Of the 77 patients who smoked, 44 smoked cigarettes, 30 cheroots, and three a pipe. There were 88 nonsmokers. At the time of surgery, the smokers were on average 6.4 years younger than the nonsmokers. The review revealed no discrepancy between smokers and nonsmokers with regard to amputation level, the BK to AK ratio being 2:1. In cigarette smokers the risk of infection and reamputation was 2:5 times higher than in cheroot smokers or nonsmokers. The poor results obtained in cigarette smokers may be ascribed to the fact that this group of patients smoked during the phase of healing and that only cigarette smokers tend to inhale. Inhalation of smoke leads to high concentrations of nicotine, which compromise the cutaneous blood-flow velocity and increase the risk of the formation of microthrombi. Consequently, amputees should abstain from cigarette smoking during the phase of healing. Preferably, the habit should be broken one week before surgery, which is the requisite period for the process of coagulation and the fibrinogen level to normalize and for free radicals to be eliminated.

Aged↗
PubMed1990

[Injured cyclists and bicycle passengers. A prospective study of the causes of accidents, accident patterns and consequences].

In a one-year prospective investigation in 1985, all bicycle accidents in Denmark were registered. The circumstances of the accident were recorded. All injuries were classified in the AIS and the ISS scales. After one year, the patients were contacted and sick leave and sequelae were registered. A total of 576 patients (320 men and 256 women), were treated after bicycle accidents. Bicycle accidents were seen most frequently in the ages from 5 to 19 years. The accidents were distributed uniformly over the week and occurred most frequently in the summer. 392 of the accidents were single-accidents, and the majority had used a bicycle-track if possible. Collision with other road users and bad road conditions were responsible for 41%, and defects in the bicycle for 9%, mainly on handlebars, front fork, front wheel, gear and chain. Two were admitted dead, and 114 were admitted to hospital (20%) for median four days. Eleven per cent had sustained serious lesions (fractures or lesions of the head). 556 had an AIS-score less or equal to three and un 387 the AIS-score was one. 561 had an ISS-score less than ten, five between ten and 75 and two had 75. Eight patients could not be classified. The patients AIS score is determined as the highest score of an injured region. AIS score of 6 is fatal. The ISS score is the addition of the square of the 3 highest AIS values. ISS of 75 is fatal. AIS is thus a value of the most serious lesion and ISS is a value of how traumatized the patient is.(ABSTRACT TRUNCATED AT 250 WORDS)

Accidents, Traffic↗