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Biomedical subjects

J Levy

Publications and source records attributed to J Levy.

At least 469 records · Page 26Linked to original sources
PubMed1982

A comparison of the ability of serum and monoclonal antibodies to gastric inhibitory polypeptide to detect immunoreactive cells in the gastroenteropancreatic system of mammals and reptiles.

A monoclonal antibody raised to gastric inhibitory polypeptide (GIP) has been compared with conventional rabbit and guinea-pig antisera to GIP. Four staining methods were tested and of these the peroxidase antiperoxidase (PAP) method proved to give the best results with both the mouse and rabbit antibodies. The monoclonal antibody, when used to stain pancreatic tissue, gave negative results whereas a distinct population of gut endocrine cells was readily demonstrable, suggesting that GIP is not a constituent of the mammalian pancreas. The monoclonal antibody was found to be the most sensitive for immunocytochemistry achieving the titre of 1:10(6) in rat gut. A C-terminal specific antibody, with a high affinity and avidity to GIP, it was clearly the preferred antibody for immunocytochemical studies.

Alligators and Crocodiles↗
PubMed1982

In vitro metabolism of cortisol by human abdominal adipose tissue.

[1,2-3H]-cortisol was incubated with homogenates of abdominal subcutaneous adipose tissue obtained from non-obese and obese female patients. In the presence of NAD or NADP 15-18% of the substrate was converted to cortisone: no other products could be detected. No cortisol metabolism could be detected upon the addition of NADH or NADPH. Kinetic studies of the dependency of cortisone formation upon incubation time, tissue and substrate concentrations showed that 11 beta-hydroxy steroid dehydrogenase activity in homogenates of adipose tissue if taken from the non-obese and obese patients is similar. The possible significance of 11 beta-hydroxy steroid dehydrogenase activity in adipose tissue is discussed.

11-beta-Hydroxysteroid Dehydrogenases↗
PubMed1982

Piperacillin pharmacokinetics in pediatric patients.

The pharmacokinetics of piperacillin were studied in 15 pediatric patients (age range, 3.3 to 14.3 years). Piperacillin was administered in a dosage of 1.5 +/- 0.4 g/m2 (mean +/- standard deviation) every 4 to 6 h. Peak serum concentrations ranged from 69 to 354 micrograms/ml. The mean elimination half-life was 37.0 +/- 13.3 min, which is shorter than that observed in most adults with normal renal function. The mean elimination half-life in three patients with renal impairment was 60.1 +/- 12.4 min, and the mean ratio of renal clearance to total clearance was 0.57. These results suggest a significant nonrenal elimination of piperacillin. Based on these data, a dosage of 1.5 g/m2 given as a 30-min infusion every 4 h is suggested for children with normal renal function. For patients with renal impairment, the daily dosage could be calculated as follows: corrected dose = normal dose x (0.35 + [0.65 x (ClCr/0.06)]), where ClCr is the creatinine clearance expressed as liters per minute per square meter.

Adolescent↗
PubMed1982

Establishing the psychiatric liaison nurse role: collaboration with the nurse administrator.

By helping patients, families, the hospital staff deal with the emotional effects of illness, the psychiatric liaison nurse plays a significant role in patients' healing. Since this type of role may be new to the organization, the psychiatric nurse and the nursing administrator must work in tandem to ensure successful role development and entry into the hospital system, both of which are crucial to the effectiveness of the liaison nurse. In our clinical experience, these issues need careful consideration and attention by both nurse administrators and psychiatric liaison nurses. We have attempted to provide practical considerations for facilitating the success of a psychiatric liaison nurse in the hospital system and justifying the value of this role.

Administrative Personnel↗
PubMed1982

The FDA Maze.

The testing of new dermatologic pharmaceutical formulations is a long and expensive process. The subsequent regulatory submissions to the Food and Drug Administration (FDA) involve considerable detail and negotiations. Most dermatologists have only a superficial knowledge of the processes involved in proving the safety and efficacy of new drugs. This article is an attempt to impart a greater understanding of the procedures involved in obtaining FDA approval of new pharmaceutical entities.

Animals↗
PubMed1982

Non oliguric acute renal failure after treatment with sulfinpyrazone.

Two cases with acute reversible renal failure while receiving sulfinpyrazone after acute myocardial infarction are presented. Sulfinpyrazone 200 mg q.i.d. was started a few days after the myocardial infarction. In both patients BUN and creatinine rose significantly, and returned to previous values when the drug was discontinued. No other known causes of renal failure were present in either of the patients.

Acute Kidney Injury↗
PubMed1982

A particular kind of negative therapeutic reaction based on Freud's 'borrowed guilt'.

Freud's clinical discovery of the negative therapeutic reaction was one of the fundamental reasons for his proposing the Structural Theory of the mind. Yet he and subsequent writers provided very few clinical examples to clarify the definitional components of this significant finding. Consequently, there have been frequent controversies as to the various meanings, manifestations and dynamics of the negative therapeutic reaction. In this paper there was an attempt to illustrate a particular kind of negative therapeutic reaction, based on Freud's explanatory concept of 'borrowed guilt', as he expounded it in The Ego and The Id. For this purpose, excerpts from an analysis before the manifestation of the negative therapeutic reaction, during, and following its resolution, are presented in this paper. This manner of presentation may provide a basis for defining the phenomenon and understanding its dynamics within the analytic process. Hopefully, this paper illustrated both one of Freud's meanings of the negative therapeutic reaction, as well as confirmed his optimistic prediction that when it is based on 'borrowed guilt', its resolution is amenable to analysis.

Adult↗
PubMed1982

[Acute respiratory failure disclosing bilateral diaphragmatic paralysis].

In the case of three patients an acute respiratory failure with alveolar hypoventilation is related to bilateral diaphragmatic paralysis apparently isolated from any other neurologic abnormalities. The current initial diagnosis of pulmonary embolism leading to admission in an intensive respiratory care unit, because of the severity of the acute respiratory failure, has to be rectified then. Bilateral diaphragmatic paralysis is suspected on account of the absence of any patent etiology, on increasing dyspnea in supine position and paradoxic movements of the upper abdomen (whether spontaneously or in attempted weaning of ventilation support). Bilateral diaphragmatic paralysis is asserted by electromyogram with measurement of nerve conduction velocities of the two phrenic nerves. In the first case, it appears early in the course of an amyotrophic lateral sclerosis; in the second case, it occurs before the presence of a herpes-zoster becomes patent. In the third case, paralysis seems to be idiopathic. Evolution is promising in the last two cases, owing to the reversibility of the lesions. The difficulty of diagnosis, the varying nature of etiology and prognosis encountered in these three cases are also apparent in the 15 cases published in medical literature. The small number of cases published up to now, contrasting with the cases we have witnessed over the last 3 years, leads us to think that this disease must exist more often and may remain unknown to us.

Adult↗
PubMed1981

Management of presumptive bacterial meningitis in childhood: a practical approach.

Precise bacteriological diagnosis in acute meningitis is sometimes difficult. The present study, in which 59 of 97 children received chemotherapy for presumptive bacterial meningitis and of whom only 40 were subsequently proved to have a bacterial aetiology, reflects this. The diagnostic data from these 97 patients have therefore been reviewed in an attempt to identify factors which may assist discrimination of bacterial from non-bacterial meningitis. A decision plan for the management of suspected bacterial meningitis, based on these results, is suggested.

Adolescent↗