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Biomedical subjects

J Lehtola

Publications and source records attributed to J Lehtola.

64 records · Page 4Linked to original sources
PubMed1976

Immunological parameters, viral antibodies, and biochemical and histological findings in relatives of patients with chronic active hepatitis and primary biliary cirrhosis.

The familial occurrence of immunological, virological, biochemical and histopathological abnormalities has been studied in 39 first degree relatives of patients with primary biliary cirrhosis (PBC) and in 58 first degree relatives of patients with chronic active hepatitis (CAH). Tissue antibodies were more frequent in relatives than in age- and sex-matched controls. Abnormal immunoglobulin levels were demonstrated in about half of the relatives. Very high antibody titres to measles and rubella occurred only in the relatives of the patients with CAH. Moreover the raised titres tended to be clustered in a few families in which also the propositi had very high viral antibody titres. Liver biopsy was performed only on the relatives with biochemical abnormalities. Unspecific inflammatory changes were observed in 5 relatives of the patients with CAH and in 4 relatives of the patients with PBC. An active liver disease was detected in two relatives of the PBC-group and in one of the CAH-group. A marked accumulation of various immunological and histopathological abnormalities in four families was observed.

Adolescent↗
PubMed1976

The possible precancerous significance of abnormal cells in gastric cytology specimens: a follow-up study of 545 patients.

In a series of 545 patients without roentgenological and gastroscopical signs of gastric malignancy, the cytological finding was interpreted as normal (Papanicolaou I) in 351 patients and abnormal (Papanicolaou II-III) in 194 patients. In the abnormal group were included 48 patients with large nuclei and 11 patients with cytologically wrong positive smears (Papanicolaou IV-V), in whom x-ray examination, gastroscopy, and a follow-up study did not reveal any signs of gastric carcinoma. The two groups were collected under uniform principles and studied by the same methods. They were also comparable as to age and sex distribution. In a 15-year follow-up study it was found that 2 patients (0.6%) in the cytologically normal group and 5 (2.6%) in the abnormal group had died of gastric carcinoma. The difference was statistically significant. The 15-year death rate from gastric carcinoma in the cytologically abnormal group was statistically significantly higher than in the expected death rate in the general population of corresponding age and sex distribution.

Adult↗
PubMed1975

Effect of indomethacin and phenylbutazone-prednisone combination of gastric mucosa: gastroscopic and histological study.

The effect of a phenylbutazone-prednisone combination and indomethacin on the anatomical state of the gastric mucosa were studied by gastroscopy, gastrophotography, and gastrobiopsy. All four patients examined had redness of the antral mucosa after administration of either drug. Intramucosal gastric haemorrhage was present in two patients after both phenylbutazone-prednisone combination and indomethacin. Mucosal erosions occurred in three cases after the phenylbutazone-prednisone combination, one of them slight, and in two cases after indomethacin. On histological examination, increased intramucosal haemorrhage could be seen in the specimens from all four patients after indomethacin, and in the specimens from three patients after the phenylbutazone-prednisone combination. There was considerable mucosal vasodilatation in one patient on the phenylbutazone-prednisone combination and in two patients on indomethacin. The effects of both drugs on the gastric mucosa were similar. None of the subjects suffered from abdominal symptoms during the drug administration.

Biopsy↗
PubMedDate not supplied

Elevated serum PIIINP and laminin in inflammatory bowel disease indicate hepatobiliary and pancreatic dysfunction.

BACKGROUND/AIMS: Levels of S-PIIINP (serum aminoterminal propeptide of type III procollagen) have been shown to be increased in patients with primary sclerosing cholangitis and inflammatory bowel disease. The aim of the study was to investigate the serum concentrations of PIIINP and laminin in inflammatory bowel disease patients, their relationship with inflammatory bowel disease-associated hepatobiliary and pancreatic dysfunction, and to correlate them with clinical, endoscopic, and histologic variables. METHODOLOGY: S-PIIINP and S-laminin were measured in 222 consecutive inflammatory bowel disease patients, who were screened for abnormal liver and pancreatic enzymes and for pancreatic exocrine hypofunction with the p-aminobenzoic acid test (215 patients). The patients with abnormal screening results were further scheduled for endoscopic retrograde cholangiopancreatography, liver biopsy, secretin test and ultrasound. RESULTS: S-PIIINP and S-laminin were abnormally high in 19% and 40% of all inflammatory bowel disease patients, respectively. The elevated levels of the fibrosis markers were associated with laboratory signs of either hepatobiliary or pancreatic disease. Hepatobiliary disease was found in 37 (17%) of inflammatory bowel disease patients, 15 of whom had primary sclerosing cholangitis. The median levels of S-PIIINP and S-laminin were significantly higher in patients with hepatobiliary disease than in those without (P < 0.0001 and P < 0.001, respectively), being most strikingly elevated in primary sclerosing cholangitis. Abnormal pancreatic screening tests were found in 67 (30%) patients. High levels of S-PIIINP and S-laminin were also significantly associated with low values in p-aminobenzoic acid (P < 0.001 and P < 0.005) and secretin (P < 0.01 and P < 0.05) tests, but not with inflammatory bowel disease category, endoscopic or histological disease extent, frequency of bowel resection or actual clinical activity. CONCLUSIONS: In inflammatory bowel disease, increased S-PIIINP and S-laminin are associated with hepatobiliary and pancreatic disorders.

Adolescent↗