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Biomedical subjects

J Laugier

Publications and source records attributed to J Laugier.

At least 145 records · Page 8Linked to original sources
PubMed1979

[Primary intra-cerebral hemorrhage in the new born, nursling and child (author's transl)].

The authors report 6 cases of intracerebral hemorrhages in 6 children, of what appears to be, of primary origin. 3 cases concern children between the ages of 4 and 14 years; the 3 others are situated shortly after birth or during the first months of life. A review of the literature emphasizes the sporadic nature of these cases and the persistance of diagnostic and etiological problems as to the cause of these hemorrhages. In the course of reviewing articles as well as our own personal series, it is evident that the cat scanner has demonstrated its qualifications as a diagnostic tool in the early detection of the lesions, permitting a better adapted treatment, thus improving their prognosis. The prognosis appears to be linked : --to an early diagnosis --to whether or not the hemorrhage is of massive nature or not --to the precise location of the hematoma --to the neurological state of the patient at the time of treatment --to the absence of an associated pathologie (severe prematurity, coagulation pathology). The long distance prognosis in the case of these apparently primary hemorrhages remains uncertain, due to the high rate of recidivism at a later unpredictable date (one month or several years later); to the occurence or not of a hydrocephalus especially in the case of young infants; and frequent sequels affecting superior functions. This long distance prognosis seems, however, to be little affected by the recent acquisitions in diagnostic testing.

Adolescent↗
PubMed1979

[Value of the intravenous route for the use of phenobarbital in asphyxiated full term newborn infants].

Phenobarbital (20 mg/kg) was given intravenously to asphyxiated full term neonates who were less than 48 hours old. Further doses were given for 4 days (5 mgs/kg/d). Plasma levels were within the therapeutic range from 5 to 36 hours after the first injection but the maintenance dose always resulted in overdose by 5th day. The exact maintenance dose needs to be determined.

Asphyxia Neonatorum↗
PubMed1979

[Monitoring of intracranial pressure in 2 severe cases of Reye's syndrome].

The intracranial pressure (PIC) of two children with Reye's sundrome aged 9 years 7 months and 4 years 7 months was monitored for 9 and 5 days respectively with a subdural device. This provided a useful guide to the treatment that was necessary to reduce the very high intracranial pressure. One of the patients died of uncontrollable raised intracranial pressure (HIC). This monitoring technique should be used in all cases of HIC.

Child↗
PubMed1978

[Colonization by enterobacteria during the first week of life in the normal newborn].

The colonisation by enterobacteria of neonates, born normally, has been studied by quantitative and qualitative techniques (by the determination of the differing patterns of antibiotic resistance). The resistant enterobacteria were less common than the sensitive strains but resistant ones were widespread in the first week of life and 6 out of 10 babies became carriers of Klebsiella. The results enabled epidemiological observations to be made (the role of the mother, who only seems to be important during delivery, and the importance of the bacteria carried on the hands of the staff), and to assess the effect of antibiotics in hospital even if they are not given to the baby.

Anti-Bacterial Agents↗
PubMed1976

[Peculiarities of hemostasis in the term newborn infant].

Haemostasis in the new-born is a product of various factors which are both qualitative and quantitative. The only factors that compare in levels and quality with those in the adult are factors V, VIII and XIII. They are alterations in the semi-analytical tests for coagulation except in the Stypven time. In contrast with this deficit shown up in haemostasis by global tests coagulation is normal and in truth there is hypercoagulability. Using Laurell's method of immunoelectrophoresis for levels of alpha 2 M high levels of this are shown contrasting with progressively lowered antithrombitic action. These paradoxes no doubt arise from the fact that neonatal haemostasis is analysed using standardised techniques and reactions which were developed for adult haemostasis, from which it is certainly as different as from those of other animals. Neonatal haemostasis is perfectly balanced in normal conditions. Important changes occur however in respiratory distress where there is a drop in factor V and soluble complexes appear, bringing about rough shapes suggestive of the subclinical syndrome of defibrination. This situation will be further developed in a forthcoming article.

Blood Coagulation Factors↗
PubMed1976

[Incidence of mother-child contamination by Candida albicans during labor].

Two different studies assessed that materno-fetal contamination at time of delivery is not the usual way of colonization of newborns with Candida albicans. In a first study, occurence of Candida albicans in neonate units disappeared owing to prophylactic measures, such as strict care in hospital hygiene. In a second study, detailed herein and performed in an obstetric ward, it was found that despite a rate of vaginal Candida carrier of 19 %, candidiasis in newborns was exceptional.

Candidiasis↗