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Biomedical subjects

J Lantos

Publications and source records attributed to J Lantos.

At least 91 records · Page 5Linked to original sources
PubMed1980

In vitro transfer of multiple resistance observed in vivo during a Salmonella london epidemic.

Between 1976 and 1978, waves of Salmonella london infections conveyed by raw meat and meat products were observed. The strains isolated during the epidemic were first susceptible then developed multiple antibiotic resistance. The identical antibiotic resistance patterns of the strain and their more frequent occurrence in hospital environments indicated plasmid-mediated resistance. R-plasmid transfer, minimum inhibition concentration and resistance elimination were studied in representative strains. The resistant S. london strain and transconjugants of Escherichia coli rendered resistant were compared. The results proved that multiple resistance was plasmid-mediated.

Anti-Bacterial Agents↗
PubMed1978

The donor kidney: I. Morphology of adequate preservation.

The structure of the dog kidney can be preserved in hypothermic intracellular-type solutions, but after 6 hours the appearance of pathologic focal changes such as mild oedema, lesions of the cellular elements, podocyte heteromorphism, vacuolization, disintegration of the basal membrane and of the cytomembrane structrues and even cell degeneration, is unavoidable.

Alkaline Phosphatase↗
PubMed1978

Study of pancreatic tissue pH in the early stage of experimental acute pancreatitis.

Pancreatic pH was measured electrometrically over a period of 3 h in 34 dogs with acute necrotic pancreatis. The disease had been induced with sunflower oil in 10, with Na-taurocholate in 10 and with hen's egg yolk in 10 animals. Four dogs served as controls. The pH of the pancreatic tissue changed differently in the different groups, in accordance with the different pathomechanisms. Injection of sunflower oil was followed by a protracted acidosis of pancreatic tissue, that of taurocholate by a transitory moderate decline of pH. Egg-yolk produced an evanescent, slight fall in pancreatic pH, followed by complete normalization within a few minutes. The differences between the initial and the 3-h values attain the level of significance only in case of sunflower-oil pancreatitis.

Acute Disease↗
PubMed1978

pH-map of the stomach of normal and vagotomized dogs.

By means of electrometric surface measurements a peculiar pH-map of the mucosa of normal and vagotomized dog stomachs was obtained illustrating the different acid producing capacities of the various regions of the stomach, on the one hand, and showing that all types of vagotomy will reduce local acid secretion.

Acetylcholine↗
PubMed1977

Transfer of erythromycin resistance in Staphylococcus aureus.

In the course of an outbreak of enteritis and conjunctivitis, Staphylococcus aureus was isolated from newborn infants. Strains cultured at a later phase of the outbreak differed from those found at the beginning in being resistant to several antibiotics, showing resistance to typing phages and releasing phages of the same lysis spectrum (10(9) p.f.u./ml after heating at 56 degrees C for 2 min). Transduction experiments with a strain and its cell-free lysate showed that inducible erythromycin resistance was transferable to strains isolated at the beginning of the outbreak and to laboratory strains. Plasmid origin of resistance was confirmed by (i) high transduction frequency; (ii) transduction to RN981 rec- mutants; (iii) kinetics of transduction; (iv) elimination of resistance. Mixed culture experiments yielded transductants at high frequency with resistance to erythromycin, streptomycin and tetracycline.

Erythromycin↗
PubMed1977

Electric activity and oxygen tension of the brain during ischaemic anoxia and reperfusion.

Electric activity of the cerebral cortex and the mesencephalon and pO2 of the brain surface were analysed in 47 dogs after serial periods of cerebral anoxia induced by clamping of the aorta for less than 3 minutes and subsequent reperfusion. After restoring the circulation, characteristic stages were observed in the normalization of cortical electric activity and pO2. Improvement in cortical oxygen utilization progressed parallel to the return of rapid activity, though normalization of the EEG preceded that of oxygen utilization. The relative duration of the stages determined from the pO2 curve and from the parameters of electric activity allowed conclusions concerning the injury of the brain tissue. It is assumed that [1] after ischaemic anoxia an excess perfusion develops in the brain; [2] during anoxia, autoregulation of the cerebral vascular system ceases simultaneously with the disintegration of the oxidative metabolic processes of the brain; [3] restitution of the cortex is indicated more reliably by its oxygen consumption rate than by the normalization of EEG activity.

Animals↗
PubMed1976

Antigenic changes in Pseudomonas aeruginosa in vivo and after lysogenization in vitro.

Pseudomonas aeruginosa cultures not conforming in antigenic structure to established serogroups were isolated from infants and from infants and from 23 O antigen type strains lysogenized with 22 different phages in vitro. The derivatives, characterized by smooth colonial form and heat stability, retained at least part of the antigens of the parent strains and became agglutinable in certain heterologous sera. All derivatives showed immunoelectrophoretic patterns identical with those of the parent strains. Antigenic analysis showed the presence of factors in the derivatives identical with (italicized figures), bilaterally related to (non-bracketed figures) or unilaterally related to (bracketed figures) O antigens of LANYI's schema: (i) changes in vivo, 01 leads to 01, (O8); O11a, 11b leads to O11a, 11c; (ii) changes in vitro, O1 leads to O1, (O8); O4a, 4b leads to O4a,4b,O1,O8,(O10a), O11; O4a,4b leads to O4a,4b,O1,O8,O10a,O11; O4a,4c leads to O4a,4c,O1,(O8),(O10a),(O11). The antigenic changes were accompanied usually by a loss of sensitivity to several typing phages and the lytic spectrum of phages released from the derivatives had become narrower. The findings suggest that multiple agglutinability of P. aeruginosa frequently encountered in nature is associated with phage action.

Antigens, Bacterial↗
PubMed1976

Viability of extracorporeally perfused dog livers.

The possibility of structural and functional preservation of the isolated liver has been studied in dog experiments. A sterile liver preparation left in situ was worked out, having practically no ischaemic period, except during perfusion. Nevertheless, well-defined lesions (perivascular and interstitial oedema, dissociated contraction of the smooth muscle elements of the veins, cellula accumulation in the sinusoids) appeared, accompanied by a gradual reduction (microcirculatory disorders, enzyme derailment) of the function of hepatocytes.

Animals↗
PubMed1975

Resorption of 125I-labeled fibrin bioplast from the dorsal muscle of rats.

Fibrin bioplast is an implant material made from plasticized fibrin. The resorption and route of elimenation of 125I-tagged bioplast plates implanted into the back muscle of rats have been studied in 18 experiments. Variation in radioactivity of the implant, appearance of the activity in the urine and fecal output, supplemented with information on the radioactivity of the implant site and that of isolated organs, reveal that the elimination of bioplast begins on the 12th day and proceeds at an even rate without pathological tissue reactions. By the 42nd day 10 to 12% of the original material is present. The elimination of the implant material is complete and occurs mainly with urine through the kidneys.

Animals↗
PubMed1975

Experimentally induced malakoplakia.

Malakoplakia was induced experimentally by introducing large amounts of crude endotoxin-antigen comples of 075 Escherichia coli (E. coli 12797 CDC 0 group 75) into the kidneys and testes of rats. First leukocytes, then granulation tissue composed mainly of characteristic macrophages, the so-called Hansemann cells, appeared around the endotoxin-antigen mass. On the eighth day following the injection, deposition of calcium phosphate into the cytosegresomes of macrophages began and acused the formation of the Michaelis-Gutmann bodies necessary for the diagnosis of malakoplakia. The induction of the same process in humans by E coli endotoxin seems to be possible.

Animals↗
PubMed1975

[Experimental malakoplakia in the kidney].

Malakoplakia in kidney of rats was caused experimentally by injection of large quantities of not purified endotoxin-antigen complex of Escherichia coli 0 75 (O. coli 127 97 CDC 0 group 75; American Type Culture Collection, Eight Edition 1968, page 24). The extract in the beginning became surrounded by leukocytes, later by macrophages. The latter then were transformed into characteristic Hansemann cells. From the 8th day on started the depletion of calcium phosphate in the cytosegresomes of macrophages, thus forming the Michaelis-Guttmann bodies, necessary for the diagnosis of malakoplakia. It is believed that complex of endoxin- and antigen of Escherichia coli may take a part - at least in certain cases - in formation of malakoplakia in human.

Animals↗